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  • Näslund, UlfUmeå universitet,Avdelningen för medicin,Arcum,Umeå Univ, Heart Ctr, Umeå, Sweden; Umeå Univ, Dept Publ Hlth & Clin Med, Umeå, Sweden (author)

Visualization of asymptomatic atherosclerotic disease for optimum cardiovascular prevention (VIPVIZA) : a pragmatic, open-label, randomised controlled trial

  • Article/chapterEnglish2019

Publisher, publication year, extent ...

  • Elsevier,2019
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-154318
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-154318URI
  • https://doi.org/10.1016/S0140-6736(18)32818-6DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-374210URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:140002194URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Erratum: Näslund, U., Ng, N., Lundgren, A., Fhärm, E., Grönlund, C., Johansson, H., … Norberg, M. (2019). Visualization of asymptomatic atherosclerotic disease for optimum cardiovascular prevention (VIPVIZA) : a pragmatic, open-label, randomised controlled trial. The Lancet, 393(10167), 133–142. DOI:10.1016/S0140-6736(18)32818-6
  • BACKGROUND: Primary prevention of cardiovascular disease often fails because of poor adherence among practitioners and individuals to prevention guidelines. We aimed to investigate whether ultrasound-based pictorial information about subclinical carotid atherosclerosis, targeting both primary care physicians and individuals, improves prevention.METHODS: Visualization of asymptomatic atherosclerotic disease for optimum cardiovascular prevention (VIPVIZA) is a pragmatic, open-label, randomised controlled trial that was integrated within the Västerbotten Intervention Programme, an ongoing population-based cardiovascular disease prevention programme in northern Sweden. Individuals aged 40, 50, or 60 years with one or more conventional risk factors were eligible to participate. Participants underwent clinical examination, blood sampling, and ultrasound assessment of carotid intima media wall thickness and plaque formation. Participants were randomly assigned 1:1 with a computer-generated randomisation list to an intervention group (pictorial representation of carotid ultrasound plus a nurse phone call to confirm understanding) or a control group (not informed). The primary outcomes, Framingham risk score (FRS) and European systematic coronary risk evaluation (SCORE), were assessed after 1 year among participants who were followed up. This study is registered with ClinicalTrials.gov, number NCT01849575.FINDINGS: 3532 individuals were enrolled between April 29, 2013, and June 7, 2016, of which 1783 were randomly assigned to the control group and 1749 were assigned to the intervention group. 3175 participants completed the 1-year follow-up. At the 1-year follow-up, FRS and SCORE differed significantly between groups (FRS 1·07 [95% CI 0·11 to 2·03, p=0·0017] and SCORE 0·16 [0·02 to 0·30, p=0·0010]). FRS decreased from baseline to the 1-year follow-up in the intervention group and increased in the control group (-0·58 [95% CI -0·86 to -0·30] vs 0·35 [0·08 to 0·63]). SCORE increased in both groups (0·13 [95% CI 0·09 to 0·18] vs 0·27 [0·23 to 0·30]).INTERPRETATION: This study provides evidence of the contributory role of pictorial presentation of silent atherosclerosis for prevention of cardiovascular disease. It supports further development of methods to reduce the major problem of low adherence to medication and lifestyle modification.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Ng, NawiUmeå universitet,Epidemiologi och global hälsa,Arcum,Umeå Univ, Unit Epidemiol & Global Hlth, Umeå, Sweden(Swepub:umu)ngna0002 (author)
  • Lundgren, Anna,1973-Umeå universitet,Epidemiologi och global hälsa,Umeå Univ, Unit Epidemiol & Global Hlth, Umeå, Sweden(Swepub:umu)anlu0244 (author)
  • Fhärm, EvaUmeå universitet,Allmänmedicin,Umeå Univ, Unit Family Med, Umeå, Sweden(Swepub:umu)evfh0001 (author)
  • Grönlund, ChristerUmeå universitet,Radiofysik,Umeå Univ, Dept Publ Hlth & Clin Med, Dept Radiat Sci, Umeå, Sweden(Swepub:umu)chgr0009 (author)
  • Johansson, Helene,1962-Umeå universitet,Epidemiologi och global hälsa,Umeå Univ, Unit Epidemiol & Global Hlth, Umeå, Sweden(Swepub:umu)hejo0002 (author)
  • Lindahl, BerntUmeå universitet,Yrkes- och miljömedicin,Umeå Univ, Unit Occupat & Environm Med, Umeå, Sweden(Swepub:umu)beli0020 (author)
  • Lindahl, Bertil,1957-Uppsala universitet,Institutionen för medicinska vetenskaper,Uppsala kliniska forskningscentrum (UCR)(Swepub:uu)belin227 (author)
  • Lindvall, Kristina,1981-Umeå universitet,Epidemiologi och global hälsa,Umeå Univ, Unit Epidemiol & Global Hlth, Umeå, Sweden(Swepub:umu)kralil01 (author)
  • Nilsson, Stefan K.,1979-Umeå universitet,Fysiologisk kemi,Umeå Univ, Unit Physiol Chem, Dept Med Biosci, Umeå, Sweden(Swepub:umu)nist6501 (author)
  • Nordin, MariaUmeå universitet,Institutionen för psykologi,Umeå Univ, Dept Psychol, Umeå, Sweden(Swepub:umu)nonmaa98 (author)
  • Nordin, Steven,1960-Umeå universitet,Institutionen för psykologi,Umeå Univ, Dept Psychol, Umeå, Sweden(Swepub:umu)stno0002 (author)
  • Nyman, EmmaUmeå universitet,Avdelningen för medicin,Umeå Univ, Heart Ctr, Umeå, Sweden; Umeå Univ, Dept Publ Hlth & Clin Med, Umeå, Sweden(Swepub:umu)emny0030 (author)
  • Rocklöv, Joacim,Professor,1979-Umeå universitet,Yrkes- och miljömedicin,Arcum,Umeå Univ, Unit Occupat & Environm Med, Umeå, Sweden(Swepub:umu)joro0003 (author)
  • Vanoli, DavideUmeå universitet,Avdelningen för medicin,Umeå Univ, Heart Ctr, Umeå, Sweden; Umeå Univ, Dept Publ Hlth & Clin Med, Umeå, Sweden(Swepub:umu)dava0013 (author)
  • Weinehall, LarsUmeå universitet,Epidemiologi och global hälsa,Arcum,Umeå Univ, Unit Epidemiol & Global Hlth, Umeå, Sweden(Swepub:umu)lawe0001 (author)
  • Wennberg, Patrik,1972-Umeå universitet,Allmänmedicin,Umeå Univ, Unit Family Med, Umeå, Sweden(Swepub:umu)pawe0002 (author)
  • Wester, PerKarolinska Institutet,Umeå universitet,Medicin,Umeå Univ, Unit Med, Umeå, Sweden(Swepub:umu)pewe0002 (author)
  • Norberg, MargaretaUmeå universitet,Epidemiologi och global hälsa,Arcum,Umeå Univ, Unit Epidemiol & Global Hlth, Umeå, Sweden(Swepub:umu)mano0062 (author)
  • Umeå universitetAvdelningen för medicin (creator_code:org_t)

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  • In:The Lancet: Elsevier393:10167, s. 133-1420140-67361474-547X

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