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CA19-9 and apolipop...
CA19-9 and apolipoprotein-A2 isoforms as detection markers for pancreatic cancer : a prospective evaluation
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- Honda, Kazufumi (author)
- Japan Science and Technology Agency (JST),National Cancer Center Research Institute, Japan
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- Katzke, Verena A. (author)
- German Cancer Research Centre
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- Hüsing, Anika (author)
- German Cancer Research Centre
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- Okaya, Shinobu (author)
- National Cancer Center Research Institute, Japan
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- Shoji, Hirokazu (author)
- National Cancer Center Hospital, Japan,National Cancer Center Research Institute, Japan
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- Onidani, Kaoru (author)
- National Cancer Center Research Institute, Japan
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- Olsen, Anja (author)
- Danish Cancer Society
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- Tjønneland, Anne (author)
- Danish Cancer Society
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- Overvad, Kim (author)
- Aarhus University
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- Weiderpass, Elisabete (author)
- Karolinska Institutet,UiT The Arctic University of Norway, Tromsø,Cancer Registry of Norway, Institute of Population-Based Cancer Research,Folkhälsan Research Center
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- Vineis, Paolo (author)
- Imperial College London
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- Muller, David (author)
- Imperial College London
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- Tsilidis, Kostas (author)
- Imperial College London,University of Ioannina
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- Palli, Domenico (author)
- Cancer Research and Prevention Institute (ISPO)
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- Pala, Valeria (author)
- Istituto Nazionale dei Tumori
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- Tumino, Rosario (author)
- Civic and M.P Arezzo Hospital
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- Naccarati, Alessio (author)
- Italian Institute for Genomic Medicine (IIGM)
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- Panico, Salvatore (author)
- University of Naples Federico II
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- Aleksandrova, Krasimira (author)
- German Institute of Human Nutrition
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- Boeing, Heiner (author)
- German Institute of Human Nutrition
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- Bueno-de-Mesquita, H. Bas (author)
- Imperial College London
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- Peeters, Petra H. (author)
- Imperial College London,University Medical Center Utrecht
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- Trichopoulou, Antonia (author)
- National and Kapodistrian University of Athens
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- Lagiou, Pagona (author)
- Harvard University
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- Khaw, Kay-Tee (author)
- University of Cambridge
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- Wareham, Nick (author)
- University of Cambridge
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- Travis, Ruth C. (author)
- University of Oxford
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- Merino, Susana (author)
- Public Health Directorate
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- Duell, Eric J. (author)
- Catalan Institute of Oncology
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- Rodríguez-Barranco, Miguel (author)
- University of Granada,CIBER Epidemiology and Public Health (CIBERESP)
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- Chirlaque, María Dolores (author)
- Murcia Regional Health Council
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- Barricarte, Aurelio (author)
- CIBER Epidemiology and Public Health (CIBERESP),Health Research Institute of Navarra (IDISNA)
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- Rebours, Vinciane (author)
- Beaujon Hospital,Paris Diderot University
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- Boutron-Ruault, Marie-Chiristine (author)
- University of Paris-Saclay,Stabilite genetique et oncogenese
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- Romana Mancini, Francesca (author)
- Paris Diderot University,University of Paris-Saclay
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- Brennan, Paul (author)
- International Agency for Research on Cancer, World Health Organization
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- Scelo, Ghislaine (author)
- International Agency for Research on Cancer, World Health Organization
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- Manjer, Jonas (author)
- Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups,Skåne University Hospital
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- Sund, Malin (author)
- Umeå University,Umeå universitet,Kirurgi,Sund
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- Öhlund, Daniel, 1979- (author)
- Umeå University,Umeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Onkologi
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- Canzian, Federico (author)
- German Cancer Research Centre
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- Kaaks, Rudolf (author)
- German Cancer Research Centre
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(creator_code:org_t)
- 2018-12-04
- 2019
- English.
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In: International Journal of Cancer. - : Wiley-Blackwell. - 0020-7136 .- 1097-0215. ; 144:8, s. 1877-1887
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http://diposit.ub.ed...
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Subject headings
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- Recently, we identified unique processing patterns of apolipoprotein A2 (ApoA2) in patients with pancreatic cancer. Our study provides a first prospective evaluation of an ApoA2 isoform ("ApoA2-ATQ/AT"), alone and in combination with carbohydrate antigen 19-9 (CA19-9), as an early detection biomarker for pancreatic cancer. We performed ELISA measurements of CA19-9 and ApoA2-ATQ/AT in 156 patients with pancreatic cancer and 217 matched controls within the European EPIC cohort, using plasma samples collected up to 60 months prior to diagnosis. The detection discrimination statistics were calculated for risk scores by strata of lag-time. For CA19-9, in univariate marker analyses, C-statistics to distinguish future pancreatic cancer patients from cancer-free individuals were 0.80 for plasma taken ≤6 months before diagnosis, and 0.71 for >6-18 months; for ApoA2-ATQ/AT, C-statistics were 0.62, and 0.65, respectively. Joint models based on ApoA2-ATQ/AT plus CA19-9 significantly improved discrimination within >6-18 months (C = 0.74 vs. 0.71 for CA19-9 alone, p = 0.022) and ≤ 18 months (C = 0.75 vs. 0.74, p = 0.022). At 98% specificity, and for lag times of ≤6, >6-18 or ≤ 18 months, sensitivities were 57%, 36% and 43% for CA19-9 combined with ApoA2-ATQ/AT, respectively, vs. 50%, 29% and 36% for CA19-9 alone. Compared to CA19-9 alone, the combination of CA19-9 and ApoA2-ATQ/AT may improve detection of pancreatic cancer up to 18 months prior to diagnosis under usual care, and may provide a useful first measure for pancreatic cancer detection prior to imaging.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- CA19-9
- apolipoprotein A2
- early detection
- isoforms
- pancreatic cancer
- prospective study
- apolipoprotein A2
- CA19-9
- early detection
- isoforms
- pancreatic cancer
- prospective study
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Honda, Kazufumi
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Katzke, Verena A ...
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Hüsing, Anika
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Okaya, Shinobu
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Shoji, Hirokazu
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Onidani, Kaoru
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show more...
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Olsen, Anja
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Tjønneland, Anne
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Overvad, Kim
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Weiderpass, Elis ...
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Vineis, Paolo
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Muller, David
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Tsilidis, Kostas
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Palli, Domenico
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Pala, Valeria
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Tumino, Rosario
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Naccarati, Aless ...
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Panico, Salvator ...
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Aleksandrova, Kr ...
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Boeing, Heiner
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Bueno-de-Mesquit ...
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Peeters, Petra H ...
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Trichopoulou, An ...
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Lagiou, Pagona
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Khaw, Kay-Tee
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Wareham, Nick
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Travis, Ruth C.
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Merino, Susana
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Duell, Eric J.
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Rodríguez-Barran ...
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Chirlaque, María ...
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Barricarte, Aure ...
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Rebours, Vincian ...
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Boutron-Ruault, ...
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Romana Mancini, ...
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Brennan, Paul
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Scelo, Ghislaine
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Manjer, Jonas
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Sund, Malin
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Öhlund, Daniel, ...
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Canzian, Federic ...
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Kaaks, Rudolf
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Surgery
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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International Jo ...
- By the university
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Umeå University
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Karolinska Institutet
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Lund University