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  • Chen, ZhishanDivision of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, TN, Nashville, United States (författare)

Fine-mapping analysis including over 254 000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes

  • Artikel/kapitelEngelska2024

Förlag, utgivningsår, omfång ...

  • Springer Nature,2024
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-224181
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-224181URI
  • https://doi.org/10.1038/s41467-024-47399-xDOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:238670944URI

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  • Språk:engelska
  • Sammanfattning på:engelska

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  • Ämneskategori:ref swepub-contenttype
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Anmärkningar

  • Genome-wide association studies (GWAS) have identified more than 200 common genetic variants independently associated with colorectal cancer (CRC) risk, but the causal variants and target genes are mostly unknown. We sought to fine-map all known CRC risk loci using GWAS data from 100,204 cases and 154,587 controls of East Asian and European ancestry. Our stepwise conditional analyses revealed 238 independent association signals of CRC risk, each with a set of credible causal variants (CCVs), of which 28 signals had a single CCV. Our cis-eQTL/mQTL and colocalization analyses using colorectal tissue-specific transcriptome and methylome data separately from 1299 and 321 individuals, along with functional genomic investigation, uncovered 136 putative CRC susceptibility genes, including 56 genes not previously reported. Analyses of single-cell RNA-seq data from colorectal tissues revealed 17 putative CRC susceptibility genes with distinct expression patterns in specific cell types. Analyses of whole exome sequencing data provided additional support for several target genes identified in this study as CRC susceptibility genes. Enrichment analyses of the 136 genes uncover pathways not previously linked to CRC risk. Our study substantially expanded association signals for CRC and provided additional insight into the biological mechanisms underlying CRC development.

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  • Guo, XingyiDivision of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, TN, Nashville, United States; Department of Biomedical Informatics, Vanderbilt University School of Medicine, TN, Nashville, United States (författare)
  • Tao, RanDepartment of Biostatistics, Vanderbilt University Medical Center, TN, Nashville, United States; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, TN, Nashville, United States (författare)
  • Huyghe, Jeroen R.Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States (författare)
  • Law, Philip J.Division of Genetics and Epidemiology, Institute of Cancer Research, London, United Kingdom (författare)
  • Fernandez-Rozadilla, CeresEdinburgh Cancer Research Centre, Institute of Genomics and Cancer, University of Edinburgh, Edinburgh, United Kingdom; Genomic Medicine Group, Instituto de Investigacion Sanitaria de Santiago, Santiago de Compostela, Spain (författare)
  • Ping, JieDivision of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, TN, Nashville, United States (författare)
  • Jia, GuochongDivision of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, TN, Nashville, United States (författare)
  • Long, JirongDivision of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, TN, Nashville, United States (författare)
  • Li, ChaoDivision of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, TN, Nashville, United States (författare)
  • Shen, QuanhuDepartment of Biostatistics, Vanderbilt University Medical Center, TN, Nashville, United States (författare)
  • Xie, YuhanDepartment of Biostatistics, Yale School of Public Health, CT, New Haven, United States (författare)
  • Timofeeva, Maria N.Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, United Kingdom; Danish Institute for Advanced Study, Department of Public Health, University of Southern Denmark, Odense, Denmark (författare)
  • Thomas, MintaPublic Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States (författare)
  • Schmit, Stephanie L.Genomic Medicine Institute, Cleveland Clinic, OH, Cleveland, United States; Population and Cancer Prevention Program, Case Comprehensive Cancer Center, OH, Cleveland, United States,Case Comprehensive Cancer Center, Case Western Reserve University, OH, Cleveland, United States,Epithelial Biology Center and Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, TN, Nashville, United States (författare)
  • Díez-Obrero, VirginiaColorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute, Barcelona, Spain; Consortium for Biomedical Research in Epidemiology and Public Health, Madrid, Spain; Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain; Oncology Data Analytics Program, Catalan Institute of Oncology, Barcelona, Spain (författare)
  • Devall, MatthewCenter for Public Health Genomics, Department of Public Health Sciences, University of Virginia, VA, Charlottesville, United States (författare)
  • Moratalla-Navarro, FerranColorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute, Barcelona, Spain; Consortium for Biomedical Research in Epidemiology and Public Health, Madrid, Spain; Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain; Oncology Data Analytics Program, Catalan Institute of Oncology, Barcelona, Spain (författare)
  • Fernandez-Tajes, JuanEdinburgh Cancer Research Centre, Institute of Genomics and Cancer, University of Edinburgh, Edinburgh, United Kingdom (författare)
  • Palles, ClaireInstitute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom (författare)
  • Sherwood, KittyEdinburgh Cancer Research Centre, Institute of Genomics and Cancer, University of Edinburgh, Edinburgh, United Kingdom (författare)
  • Briggs, Sarah E. W.Department of Public Health, Richard Doll Building, University of Oxford, Oxford, United Kingdom,Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, TN, Nashville, United States,Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States; Department of Epidemiology, University of Washington School of Public Health, WA, Seattle, United States (författare)
  • Svinti, VictoriaColon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, United Kingdom (författare)
  • Donnelly, KevinColon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, United Kingdom,Clalit National Cancer Control Center, Haifa, Israel; Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel; Department of Medical Oncology and Center For Precision Medicine, City of Hope National Medical Center, CA, Duarte, United States (författare)
  • Farrington, Susan M.Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, United Kingdom,The Steve and Cindy Rasmussen Institute for Genomic Medicine, Nationwide Children’s Hospital, OH, Columbus, United States (författare)
  • Blackmur, JamesColon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, United Kingdom,Division of Epidemiology, Department of Population Health, New York University School of Medicine, NY, New York, United States (författare)
  • Vaughan-Shaw, Peter G.Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, United Kingdom,Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, VIC, Melbourne, Australia; Cancer Epidemiology Division, Cancer Council Victoria, VIC, Melbourne, Australia; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, VIC, Clayton, Australia (författare)
  • Shu, Xiao-OuDivision of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, TN, Nashville, United States (författare)
  • Lu, YingchangDivision of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, TN, Nashville, United States (författare)
  • Broderick, PeterDivision of Genetics and Epidemiology, Institute of Cancer Research, London, United Kingdom (författare)
  • Studd, JamesDivision of Genetics and Epidemiology, Institute of Cancer Research, London, United Kingdom (författare)
  • Harrison, Tabitha A.Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States (författare)
  • Conti, David V.Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States,Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic; Faculty of Medicine and Biomedical Center in Pilsen, Charles University, Pilsen, Czech Republic; Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic (författare)
  • Schumacher, Fredrick R.Case Comprehensive Cancer Center, Case Western Reserve University, OH, Cleveland, United States; Department of Population and Quantitative Health Sciences, Case Western Reserve University, OH, Cleveland, United States (författare)
  • Melas, MarilenaThe Steve and Cindy Rasmussen Institute for Genomic Medicine, Nationwide Children’s Hospital, OH, Columbus, United States,Huntsman Cancer Institute and Department of Population Health Sciences, University of Utah, UT, Salt Lake City, United States,Division of Human Nutrition, Wageningen University and Research, Wageningen, Netherlands,Cancer Epidemiology Division, Cancer Council Victoria, VIC, Melbourne, Australia; Menzies Institute for Medical Research, University of Tasmania, TAS, Hobart, Australia (författare)
  • Rennert, GadClalit National Cancer Control Center, Haifa, Israel; Department of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel; Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel (författare)
  • Obón-Santacana, MireiaColorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute, Barcelona, Spain; Consortium for Biomedical Research in Epidemiology and Public Health, Madrid, Spain; Oncology Data Analytics Program, Catalan Institute of Oncology, Barcelona, Spain (författare)
  • Martín-Sánchez, VicenteConsortium for Biomedical Research in Epidemiology and Public Health, Madrid, Spain; Biomedicine Institute, University of León, León, Spain (författare)
  • Oh, Jae HwanCenter for Colorectal Cancer, National Cancer Center Hospital, National Cancer Center, Gyeonggi-do, South Korea (författare)
  • Kim, JeongseonDepartment of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center, Gyeonggi-do, South Korea (författare)
  • Jee, Sun HaDepartment of Epidemiology and Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, South Korea (författare)
  • Jung, Keum JiDepartment of Epidemiology and Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, South Korea (författare)
  • Kweon, Sun-SeogDepartment of Preventive Medicine, Chonnam National University Medical School, Gwangju, South Korea (författare)
  • Shin, Min-HoDepartment of Preventive Medicine, Chonnam National University Medical School, Gwangju, South Korea (författare)
  • Shin, AesunCancer Research Institute, Seoul National University, Seoul, South Korea; Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, South Korea (författare)
  • Ahn, Yoon-OkDepartment of Preventive Medicine, Seoul National University College of Medicine, Seoul, South Korea (författare)
  • Kim, Dong-HyunDepartment of Social and Preventive Medicine, Hallym University College of Medicine, Okcheon-dong, South Korea (författare)
  • Oze, IsaoDivision of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (författare)
  • Wen, WanqingDivision of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, TN, Nashville, United States,Division of Oncology, Department of Medicine, Cedars-Sinai Cancer Research Center for Health Equity, CA, Los Angeles, United States,Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States (författare)
  • Matsuo, KeitaroDepartment of Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, Japan; Division of Molecular and Clinical Epidemiology, Aichi Cancer Center Research Institute, Nagoya, Japan (författare)
  • Matsuda, KoichiLaboratory of Clinical Genome Sequencing, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, University of Tokyo, Tokyo, Japan (författare)
  • Tanikawa, ChizuLaboratory of Genome Technology, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan (författare)
  • Ren, ZefangSchool of Public Health, Sun Yat-sen University, Guangzhou, China (författare)
  • Gao, Yu-TangState Key Laboratory of Oncogenes and Related Genes and Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China (författare)
  • Jia, Wei-HuaState Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou, China (författare)
  • Hopper, John L.Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, VIC, Melbourne, Australia; Department of Epidemiology, School of Public Health and Institute of Health and Environment, Seoul National University, Seoul, South Korea (författare)
  • Jenkins, Mark A.Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, VIC, Melbourne, Australia (författare)
  • Win, Aung KoCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, VIC, Melbourne, Australia (författare)
  • Pai, Rish K.Department of Laboratory Medicine and Pathology, Mayo Clinic Arizona, AZ, Scottsdale, United States (författare)
  • Figueiredo, Jane C.Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States; Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, CA, Los Angeles, United States (författare)
  • Haile, Robert W.Division of Oncology, Department of Medicine, Cedars-Sinai Cancer Research Center for Health Equity, CA, Los Angeles, United States (författare)
  • Gallinger, StevenLunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, ON, Toronto, Canada (författare)
  • Woods, Michael O.Division of Biomedical Sciences, Memorial University of Newfoundland, ON, St. John, Canada (författare)
  • Newcomb, Polly A.Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States; School of Public Health, University of Washington, WA, Seattle, United States (författare)
  • Duggan, DavidCity of Hope National Medical Center, Translational Genomics Research Institute, AZ, Phoenix, United States,Colorectal Oncogenomics Group, Department of Clinical Pathology, University of Melbourne, VIC, Parkville, Australia; Genomic Medicine and Family Cancer Clinic, Royal Melbourne Hospital, VIC, Parkville, Australia; University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, VIC, Parkville, Australia,Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States; Research Centre for Hauora and Health, Massey University, Wellington, New Zealand,Leeds Institute of Medical Research at St James’s, University of Leeds, Leeds, United Kingdom,Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom,Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States (författare)
  • Cheadle, Jeremy P.Institute of Medical Genetics, Cardiff University, Cardiff, United Kingdom (författare)
  • Kaplan, RichardMRC Clinical Trials Unit, Medical Research Council, Cardiff, United Kingdom (författare)
  • Kerr, RachelDepartment of Oncology, University of Oxford, Oxford, United Kingdom (författare)
  • Kerr, DavidRadcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom (författare)
  • Kirac, IvaDepartment of Surgical Oncology, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia (författare)
  • Böhm, JanDepartment of Pathology, Central Finland Health Care District, Jyväskylä, Finland (författare)
  • Mecklin, Jukka-PekkaCentral Finland Health Care District, Jyväskylä, Finland (författare)
  • Jousilahti, PekkaDepartment of Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland (författare)
  • Knekt, PaulDepartment of Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland (författare)
  • Aaltonen, Lauri A.Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland; Genome-Scale Biology Research Program, University of Helsinki, Helsinki, Finland (författare)
  • Rissanen, HarriDepartment of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland (författare)
  • Pukkala, EeroFaculty of Social Sciences, Tampere University, Tampere, Finland; Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Helsinki, Finland (författare)
  • Eriksson, Johan G.Folkhälsan Research Centre, University of Helsinki, Helsinki, Finland; Human Potential Translational Research Programme, National University of Singapore, Singapore, Singapore; Unit of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland (författare)
  • Cajuso, TatianaDepartment of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland; Genome-Scale Biology Research Program, University of Helsinki, Helsinki, Finland (författare)
  • Hänninen, UlrikaDepartment of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland; Genome-Scale Biology Research Program, University of Helsinki, Helsinki, Finland (författare)
  • Kondelin, JohannaDepartment of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland; Genome-Scale Biology Research Program, University of Helsinki, Helsinki, Finland (författare)
  • Palin, KimmoDepartment of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland; Genome-Scale Biology Research Program, University of Helsinki, Helsinki, Finland (författare)
  • Tanskanen, TomasDepartment of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland; Genome-Scale Biology Research Program, University of Helsinki, Helsinki, Finland,Department of Epidemiology and Population Health, Albert Einstein College of Medicine, NY, New York, United States,Broad Institute of Harvard and MIT, MA, Cambridge, United States; Channing Division of Network Medicine, Brigham and Women’s Hospital and Harvard Medical School, MA, Boston, United States; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States (författare)
  • Renkonen-Sinisalo, LauraDepartment of Surgery, Abdominal Centre, Helsinki University Hospital, Helsinki, Finland (författare)
  • Männistö, SatuDepartment of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland (författare)
  • Albanes, DemetriusDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States (författare)
  • Weinstein, Stephanie J.Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States (författare)
  • Ruiz-Narvaez, EdwardDepartment of Nutritional Sciences, School of Public Health, University of Michigan, MI, Ann Arbor, United States (författare)
  • Palmer, Julie R.Department of Medicine, Boston University School of Medicine, MA, Boston, United States; Slone Epidemiology Center at Boston University, MA, Boston, United States (författare)
  • Buchanan, Daniel D.Colorectal Oncogenomics Group, Department of Clinical Pathology, University of Melbourne, VIC, Parkville, Australia; Genomic Medicine and Family Cancer Clinic, Royal Melbourne Hospital, VIC, Parkville, Australia; University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, VIC, Parkville, Australia (författare)
  • Platz, Elizabeth A.Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, MD, Baltimore, United States (författare)
  • Visvanathan, KalaDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, MD, Baltimore, United States (författare)
  • Ulrich, Cornelia M.Huntsman Cancer Institute and Department of Population Health Sciences, University of Utah, UT, Salt Lake City, United States (författare)
  • Siegel, ErinCancer Epidemiology Program, H. Lee Moffitt Cancer Center and Research Institute, FL, Tampa, United States (författare)
  • Brezina, StefanieInstitute of Cancer Research, Department of Medicine I, Medical University Vienna, Vienna, Austria (författare)
  • Gsur, AndreaInstitute of Cancer Research, Department of Medicine I, Medical University Vienna, Vienna, Austria (författare)
  • Campbell, Peter T.Department of Epidemiology and Population Health, Albert Einstein College of Medicine, NY, New York, United States (författare)
  • Chang-Claude, JennyDivision of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany; University Medical Centre Hamburg-Eppendorf, University Cancer Centre Hamburg, Hamburg, Germany (författare)
  • Hoffmeister, MichaelDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany (författare)
  • Brenner, HermannDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany; Division of Preventive Oncology, German Cancer Research Center and National Center for Tumor Diseases, Heidelberg, Germany; German Cancer Consortium, German Cancer Research Center, Heidelberg, Germany (författare)
  • Slattery, Martha L.Department of Internal Medicine, University of Utah, UT, Salt Lake City, United States (författare)
  • Potter, John D.Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States; Research Centre for Hauora and Health, Massey University, Wellington, New Zealand (författare)
  • Tsilidis, Kostas K.Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom; Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece (författare)
  • Schulze, Matthias B.Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; Institute of Nutritional Science, University of Potsdam, Potsdam, Germany (författare)
  • Gunter, Marc J.Nutrition and Metabolism Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France (författare)
  • Murphy, NeilNutrition and Metabolism Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France (författare)
  • Castells, AntoniGastroenterology Department, Hospital Clínic, Institut d’Investigacions Biomèdiques August Pi i Sunyer, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, University of Barcelona, Barcelona, Spain (författare)
  • Castellví-Bel, SergiGastroenterology Department, Hospital Clínic, Institut d’Investigacions Biomèdiques August Pi i Sunyer, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, University of Barcelona, Barcelona, Spain (författare)
  • Moreira, LeticiaGastroenterology Department, Hospital Clínic, Institut d’Investigacions Biomèdiques August Pi i Sunyer, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, University of Barcelona, Barcelona, Spain (författare)
  • Arndt, VolkerDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany (författare)
  • Shcherbina, AnnaDepartment of Genetics, Stanford University, CA, Stanford, United States (författare)
  • Bishop, D. TimothyLeeds Institute of Medical Research at St James’s, University of Leeds, Leeds, United Kingdom (författare)
  • Giles, Graham G.Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, VIC, Melbourne, Australia; Cancer Epidemiology Division, Cancer Council Victoria, VIC, Melbourne, Australia; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, VIC, Clayton, Australia,Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, United Kingdom (författare)
  • Southey, Melissa C.Cancer Epidemiology Division, Cancer Council Victoria, VIC, Melbourne, Australia; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, VIC, Clayton, Australia; Department of Clinical Pathology, University of Melbourne, VIC, Melbourne, Australia (författare)
  • Idos, Gregory E.Department of Medical Oncology and Center For Precision Medicine, City of Hope National Medical Center, CA, Duarte, United States (författare)
  • McDonnell, Kevin J.Clalit National Cancer Control Center, Haifa, Israel; Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel; Department of Medical Oncology and Center For Precision Medicine, City of Hope National Medical Center, CA, Duarte, United States (författare)
  • Abu-Ful, ZomorodaDepartment of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel (författare)
  • Greenson, Joel K.Clalit National Cancer Control Center, Haifa, Israel; Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel; Department of Pathology, University of Michigan, MI, Ann Arbor, United States (författare)
  • Shulman, KaterinaDepartment of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel (författare)
  • Lejbkowicz, FlavioClalit National Cancer Control Center, Haifa, Israel; Department of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel; Clalit Health Services, Personalized Genomic Service, Lady Davis Carmel Medical Center, Haifa, Israel (författare)
  • Offit, KennethClinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, NY, New York, United States; Department of Medicine, Weill Cornell Medical College, NY, New York, United States (författare)
  • Su, Yu-RuKaiser Permanente Washington Health Research Institute, WA, Seattle, United States (författare)
  • Steinfelder, RobertPublic Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States (författare)
  • Keku, Temitope O.Center for Gastrointestinal Biology and Disease, University of North Carolina, NC, Chapel Hill, United States (författare)
  • van Guelpen, BethanyUmeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Onkologi(Swepub:umu)beyvan99 (författare)
  • Hudson, Thomas J.Ontario Institute for Cancer Research, ON, Toronto, Canada (författare)
  • Hampel, HeatherDivision of Human Genetics, Department of Internal Medicine, Ohio State University Comprehensive Cancer Center, OH, Columbus, United States,Preventative Medicine, University of Southern California, CA, Los Angeles, United States (författare)
  • Pearlman, RachelDivision of Human Genetics, Department of Internal Medicine, Ohio State University Comprehensive Cancer Center, OH, Columbus, United States (författare)
  • Berndt, Sonja I.Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States (författare)
  • Hayes, Richard B.Division of Epidemiology, Department of Population Health, New York University School of Medicine, NY, New York, United States (författare)
  • Martinez, Marie ElenaDepartment of Family Medicine and Public Health, University of California San Diego, La Jolla, CA, United States; Population Sciences, Disparities and Community Engagement, University of California San Diego Moores Cancer Center, La Jolla, CA, United States (författare)
  • Thomas, Sushma S.Fred Hutchinson Cancer Center, WA, Seattle, United States (författare)
  • Pharoah, Paul D. P.Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom (författare)
  • Larsson, Susanna C.Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden (författare)
  • Yen, YunTaipei Medical University, Taipei, Taiwan,Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, United Kingdom; Department of Pathology, National University Hospital, National University Health System, Singapore, Singapore (författare)
  • Lenz, Heinz-JosefDepartment of Medicine, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States (författare)
  • White, EmilyPublic Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States; Department of Epidemiology, University of Washington School of Public Health, WA, Seattle, United States (författare)
  • Li, LiCase Comprehensive Cancer Center, Case Western Reserve University, OH, Cleveland, United States,Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States; Department of Biostatistics, School of Public Health, University of Washington, WA, Seattle, United States (författare)
  • Doheny, Kimberly F.Center for Inherited Disease Research, Department of Genetic Medicine, Johns Hopkins University School of Medicine, MD, Baltimore, United States (författare)
  • Pugh, ElizabethCenter for Inherited Disease Research, Department of Genetic Medicine, Johns Hopkins University School of Medicine, MD, Baltimore, United States (författare)
  • Shelford, TamekaCenter for Inherited Disease Research, Department of Genetic Medicine, Johns Hopkins University School of Medicine, MD, Baltimore, United States (författare)
  • Chan, Andrew T.Broad Institute of Harvard and MIT, MA, Cambridge, United States; Channing Division of Network Medicine, Brigham and Women’s Hospital and Harvard Medical School, MA, Boston, United States; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States (författare)
  • Cruz-Correa, MarciaComprehensive Cancer Center, University of Puerto Rico, San Juan, Puerto Rico (författare)
  • Lindblom, AnnikaKarolinska Institutet,Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden (författare)
  • Hunter, David J.Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States; Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom (författare)
  • Joshi, Amit D.Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States (författare)
  • Schafmayer, ClemensDepartment of General Surgery, University Hospital Rostock, Rostock, Germany (författare)
  • Scacheri, Peter C.Department of Genetics and Genome Sciences, Case Western Reserve University, OH, Cleveland, United States (författare)
  • Kundaje, AnshulDepartment of Genetics, Stanford University, CA, Stanford, United States; Department of Computer Science, Stanford University, CA, Stanford, United States (författare)
  • Schoen, Robert E.Department of Medicine and Epidemiology, University of Pittsburgh Medical Center, PA, Pittsburgh, United States (författare)
  • Hampe, JochenDepartment of Medicine I, University Hospital Dresden, Technische Universität Dresden, Dresden, Germany (författare)
  • Stadler, Zsofia K.Department of Medicine, Weill Cornell Medical College, NY, New York, United States; Department of Medicine, Memorial Sloan-Kettering Cancer Center, NY, New York, United States (författare)
  • Vodicka, PavelDepartment of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic; Faculty of Medicine and Biomedical Center in Pilsen, Charles University, Pilsen, Czech Republic; Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic (författare)
  • Vodickova, LudmilaDepartment of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic; Faculty of Medicine and Biomedical Center in Pilsen, Charles University, Pilsen, Czech Republic; Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic (författare)
  • Vymetalkova, VeronikaDepartment of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic; Faculty of Medicine and Biomedical Center in Pilsen, Charles University, Pilsen, Czech Republic; Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic (författare)
  • Edlund, Christopher K.Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States (författare)
  • Gauderman, W. JamesDepartment of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States (författare)
  • Shibata, DavidDepartment of Surgery, University of Tennessee Health Science Center, TN, Memphis, United States (författare)
  • Toland, AmandaDepartments of Cancer Biology and Genetics and Internal Medicine, Comprehensive Cancer Center, Ohio State University, OH, Columbus, United States (författare)
  • Markowitz, SanfordDepartments of Medicine and Genetics, Case Comprehensive Cancer Center, Case Western Reserve University and University Hospitals of Cleveland, OH, Cleveland, United States (författare)
  • Kim, AndreDepartment of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States (författare)
  • Chanock, Stephen J.Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States (författare)
  • van Duijnhoven, FranzelDivision of Human Nutrition and Health, Wageningen University and Research, Wageningen, Netherlands (författare)
  • Feskens, Edith J. M.Division of Human Nutrition, Wageningen University and Research, Wageningen, Netherlands (författare)
  • Sakoda, Lori C.Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States; Division of Research, Kaiser Permanente Northern California, CA, Oakland, United States (författare)
  • Gago-Dominguez, ManuelaGenomic Medicine Group, Galician Public Foundation of Genomic Medicine, Servicio Galego de Saude, Santiago de Compostela, Spain; Instituto de Investigación Sanitaria de Santiago de Compostela, Santiago de Compostela, Spain (författare)
  • Wolk, AlicjaKarolinska Institutet,Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden (författare)
  • Pardini, BarbaraCandiolo Cancer Institute FPO-IRCCS, (TO), Candiolo, Italy; Italian Institute for Genomic Medicine, Candiolo Cancer Institute FPO-IRCCS, (TO), Candiolo, Italy (författare)
  • FitzGerald, Liesel M.Cancer Epidemiology Division, Cancer Council Victoria, VIC, Melbourne, Australia; Menzies Institute for Medical Research, University of Tasmania, TAS, Hobart, Australia (författare)
  • Lee, Soo ChinNational University Cancer Institute, Singapore, Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore (författare)
  • Ogino, ShujiDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States; Broad Institute of MIT and Harvard, MA, Cambridge, United States; Cancer Immunology Program, Dana-Farber Harvard Cancer Center, MA, Boston, United States; Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, MA, Boston, United States (författare)
  • Bien, Stephanie A.Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States (författare)
  • Kooperberg, CharlesPublic Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States (författare)
  • Li, Christopher I.Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States (författare)
  • Lin, YiPublic Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States (författare)
  • Prentice, RossPublic Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States; Department of Biostatistics, University of Washington, WA, Seattle, United States (författare)
  • Qu, ConghuiPublic Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States (författare)
  • Bézieau, StéphaneService de Génétique Médicale, Centre Hospitalier Universitaire Nantes, Nantes, France,Department of Medical Oncology and Center For Precision Medicine, City of Hope National Medical Center, CA, Duarte, United States (författare)
  • Yamaji, TaikiDivision of Epidemiology, National Cancer Center Institute for Cancer Control, National Cancer Center, Tokyo, Japan (författare)
  • Sawada, NorieDivision of Cohort Research, National Cancer Center Institute for Cancer Control, National Cancer Center, Tokyo, Japan (författare)
  • Iwasaki, MotokiDivision of Epidemiology, National Cancer Center Institute for Cancer Control, National Cancer Center, Tokyo, Japan; Division of Cohort Research, National Cancer Center Institute for Cancer Control, National Cancer Center, Tokyo, Japan (författare)
  • Le Marchand, LoicCancer Center, University of Hawaii, HI, Honolulu, United States (författare)
  • Wu, Anna H.Preventative Medicine, University of Southern California, CA, Los Angeles, United States (författare)
  • Qu, ChenxuUSC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States (författare)
  • McNeil, Caroline E.USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States (författare)
  • Coetzee, GerhardVan Andel Research Institute, MI, Grand Rapids, United States (författare)
  • Hayward, CarolineMRC Human Genetics Unit, Institute of Genomics and Cancer, University of Edinburgh, Edinburgh, United Kingdom (författare)
  • Deary, Ian J.Lothian Birth Cohorts group, Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom (författare)
  • Harris, Sarah E.Lothian Birth Cohorts group, Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom (författare)
  • Theodoratou, EvropiCentre for Global Health, Usher Institute, University of Edinburgh, Edinburgh, United Kingdom (författare)
  • Reid, StuartColon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, United Kingdom (författare)
  • Walker, MarionColon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, United Kingdom (författare)
  • Ooi, Li YinColon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, United Kingdom; Department of Pathology, National University Hospital, National University Health System, Singapore, Singapore (författare)
  • Lau, Ken S.Epithelial Biology Center and Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, TN, Nashville, United States (författare)
  • Zhao, HongyuDepartment of Biostatistics, Yale School of Public Health, CT, New Haven, United States; Department of Genetics, Yale School of Medicine, CT, New Haven, United States; Program in Computational Biology and Bioinformatics, Yale University, CT, New Haven, United States (författare)
  • Hsu, LiPublic Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States; Department of Biostatistics, School of Public Health, University of Washington, WA, Seattle, United States (författare)
  • Cai, QiuyinDivision of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, TN, Nashville, United States (författare)
  • Dunlop, Malcolm G.Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, United Kingdom (författare)
  • Gruber, Stephen B.Department of Medical Oncology and Center For Precision Medicine, City of Hope National Medical Center, CA, Duarte, United States (författare)
  • Houlston, Richard S.Division of Genetics and Epidemiology, Institute of Cancer Research, London, United Kingdom (författare)
  • Moreno, VictorColorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute, Barcelona, Spain; Consortium for Biomedical Research in Epidemiology and Public Health, Madrid, Spain; Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain; Oncology Data Analytics Program, Catalan Institute of Oncology, Barcelona, Spain (författare)
  • Casey, GrahamCenter for Public Health Genomics, Department of Public Health Sciences, University of Virginia, VA, Charlottesville, United States (författare)
  • Peters, UlrikePublic Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States; Department of Epidemiology, University of Washington, WA, Seattle, United States (författare)
  • Tomlinson, IanEdinburgh Cancer Research Centre, Institute of Genomics and Cancer, University of Edinburgh, Edinburgh, United Kingdom; Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom (författare)
  • Zheng, WeiDivision of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, TN, Nashville, United States (författare)
  • Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, TN, Nashville, United StatesDivision of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, TN, Nashville, United States; Department of Biomedical Informatics, Vanderbilt University School of Medicine, TN, Nashville, United States (creator_code:org_t)

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  • Ingår i:Nature Communications: Springer Nature15:12041-1723

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