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Circulating high se...
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Muller, David C.Imperial College London,International Agency for Research on Cancer, World Health Organization
(författare)
Circulating high sensitivity C reactive protein concentrations and risk of lung cancer : nested case-control study within Lung Cancer Cohort Consortium
- Artikel/kapitelEngelska2019
Förlag, utgivningsår, omfång ...
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2019-01-03
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BMJ Publishing Group Ltd,2019
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:umu-155763
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-155763URI
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https://doi.org/10.1136/bmj.k4981DOI
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https://lup.lub.lu.se/record/8ae20080-d8b7-4f35-aeaa-6212fbaeb6b4URI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Objectives To conduct a comprehensive analysis of prospectively measured circulating high sensitivity C reactive protein (hsCRP) concentration and risk of lung cancer overall, by smoking status (never, former, and current smokers), and histological sub-type.Design Nested case-control study.Setting 20 population based cohort studies in Asia, Europe, Australia, and the United States.Participants 5299 patients with incident lung cancer, with individually incidence density matched controls.Exposure Circulating hsCRP concentrations in prediagnostic serum or plasma samples.Main outcome measure Incident lung cancer diagnosis.Results A positive association between circulating hsCRP concentration and the risk of lung cancer for current (odds ratio associated with a doubling in hsCRP concentration 1.09, 95% confidence interval 1.05 to 1.13) and former smokers (1.09, 1.04 to 1.14) was observed, but not for never smokers (P<0.01 for interaction). This association was strong and consistent across all histological subtypes, except for adenocarcinoma, which was not strongly associated with hsCRP concentration regardless of smoking status (odds ratio for adenocarcinoma overall 0.97, 95% confidence interval 0.94 to 1.01). The association between circulating hsCRP concentration and the risk of lung cancer was strongest in the first two years of follow-up for former and current smokers. Including hsCRP concentration in a risk model, in addition to smoking based variables, did not improve risk discrimination overall, but slightly improved discrimination for cancers diagnosed in the first two years of follow-up.Conclusions Former and current smokers with higher circulating hsCRP concentrations had a higher risk of lung cancer overall. Circulating hsCRP concentration was not associated with the risk of lung adenocarcinoma. Circulating hsCRP concentration could be a prediagnostic marker of lung cancer rather than a causal risk factor.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Larose, Tricia L.International Agency for Research on Cancer, World Health Organization,Norwegian University of Science and Technology
(författare)
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Hodge, AllisonUniversity of Melbourne,Cancer Council Victoria
(författare)
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Guida, FlorenceInternational Agency for Research on Cancer, World Health Organization
(författare)
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Langhammer, ArnulfNorwegian University of Science and Technology
(författare)
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Grankvist, KjellUmeå University,Umeå universitet,Klinisk kemi(Swepub:umu)kjgr0002
(författare)
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Meyer, KlausBevital AS
(författare)
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Cai, QiuyinVanderbilt University
(författare)
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Arslan, Alan A.New York University,University of Arizona
(författare)
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Zeleniuch-Jacquotte, AnneNew York University
(författare)
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Albanes, DemetriusNational Cancer Institute, USA
(författare)
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Giles, Graham G.University of Melbourne,Cancer Council Victoria
(författare)
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Sesso, Howard D.Brigham and Women's Hospital / Harvard Medical School,Harvard University
(författare)
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Lee, I-MinBrigham and Women's Hospital / Harvard Medical School,Harvard University
(författare)
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Gaziano, J. MichaelUmeå University
(författare)
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Yuan, Jian-MinUniversity of Pittsburgh
(författare)
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Bolton, Judith HoffmanJohns Hopkins Bloomberg School of Public Health
(författare)
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Buring, Julie E.Harvard University,Brigham and Women's Hospital / Harvard Medical School
(författare)
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Visvanathan, KalaJohns Hopkins Bloomberg School of Public Health
(författare)
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Le Marchand, Loic
(författare)
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Purdue, Mark P.National Cancer Institute, USA,Fred Hutchinson Cancer Research Center
(författare)
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Caporaso, Neil E.National Cancer Institute, USA
(författare)
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Midttun, OivindBevital AS
(författare)
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Ueland, Per M.University of Bergen,Haukeland University Hospital
(författare)
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Prentice, Ross L.University of Bergen,Haukeland University Hospital
(författare)
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Weinstein, Stephanie J.National Cancer Institute, USA
(författare)
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Stevens, Victoria L.American Cancer Society
(författare)
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Zheng, WeiVanderbilt University
(författare)
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Blot, William J.Vanderbilt University
(författare)
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Shu, Xiao-OuVanderbilt University
(författare)
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Zhang, XuehongBrigham and Women's Hospital / Harvard Medical School
(författare)
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Xiang, Yong-BingRenji Hospital
(författare)
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Koh, Woon-PuayDuke–NUS Medical School
(författare)
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Hveem, KristianItalian Institute for Genomic Medicine (IIGM)
(författare)
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Thomson, Cynthia A.
(författare)
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Pettinger, Mary
(författare)
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Engström, GunnarLund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups(Swepub:lu)smi-gen
(författare)
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Brunnström, HansLund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Förbättrad diagnostik och prognostik vid lungcancer och metastaser till lunga,Forskargrupper vid Lunds universitet,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Improved diagnostics and prognostics of lung cancer and metastases to the lungs,Lund University Research Groups,Region Skåne(Swepub:lu)med-hsb
(författare)
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Milne, Roger L.University of Melbourne,Cancer Council Victoria
(författare)
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Stampfer, Meir J.Harvard University,Brigham and Women's Hospital / Harvard Medical School
(författare)
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Han, Jiali
(författare)
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Johansson, MikaelUmeå universitet,Onkologi(Swepub:umu)mijo0025
(författare)
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Brennan, PaulInternational Agency for Research on Cancer, World Health Organization
(författare)
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Severi, GianlucaVersailles Saint-Quentin-en-Yvelines University,Cancer Council Victoria
(författare)
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Johansson, MattiasInternational Agency for Research on Cancer, World Health Organization
(författare)
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Imperial College LondonInternational Agency for Research on Cancer, World Health Organization
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:The BMJ: BMJ Publishing Group Ltd3641756-18330959-8138
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Ingår i:BMJ: BMJ Publishing Group Ltd3640959-8138
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Till lärosätets databas
- Av författaren/redakt...
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Muller, David C.
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Larose, Tricia L ...
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Hodge, Allison
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Guida, Florence
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Langhammer, Arnu ...
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Grankvist, Kjell
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visa fler...
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Meyer, Klaus
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Cai, Qiuyin
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Arslan, Alan A.
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Zeleniuch-Jacquo ...
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Albanes, Demetri ...
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Giles, Graham G.
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Sesso, Howard D.
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Lee, I-Min
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Gaziano, J. Mich ...
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Yuan, Jian-Min
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Bolton, Judith H ...
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Buring, Julie E.
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Visvanathan, Kal ...
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Le Marchand, Loi ...
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Purdue, Mark P.
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Caporaso, Neil E ...
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Midttun, Oivind
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Ueland, Per M.
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Prentice, Ross L ...
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Weinstein, Steph ...
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Stevens, Victori ...
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Zheng, Wei
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Blot, William J.
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Shu, Xiao-Ou
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Zhang, Xuehong
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Xiang, Yong-Bing
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Koh, Woon-Puay
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Hveem, Kristian
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Thomson, Cynthia ...
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Pettinger, Mary
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Engström, Gunnar
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Brunnström, Hans
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Milne, Roger L.
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Stampfer, Meir J ...
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Han, Jiali
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Johansson, Mikae ...
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Brennan, Paul
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Severi, Gianluca
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Johansson, Matti ...
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