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Circulating high se...
Circulating high sensitivity C reactive protein concentrations and risk of lung cancer : nested case-control study within Lung Cancer Cohort Consortium
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- Muller, David C. (författare)
- Imperial College London,International Agency for Research on Cancer, World Health Organization
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- Larose, Tricia L. (författare)
- International Agency for Research on Cancer, World Health Organization,Norwegian University of Science and Technology
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- Hodge, Allison (författare)
- University of Melbourne,Cancer Council Victoria
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- Guida, Florence (författare)
- International Agency for Research on Cancer, World Health Organization
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- Langhammer, Arnulf (författare)
- Norwegian University of Science and Technology
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- Grankvist, Kjell (författare)
- Umeå University,Umeå universitet,Klinisk kemi
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- Meyer, Klaus (författare)
- Bevital AS
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- Cai, Qiuyin (författare)
- Vanderbilt University
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- Arslan, Alan A. (författare)
- New York University,University of Arizona
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- Zeleniuch-Jacquotte, Anne (författare)
- New York University
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- Albanes, Demetrius (författare)
- National Cancer Institute, USA
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- Giles, Graham G. (författare)
- University of Melbourne,Cancer Council Victoria
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- Sesso, Howard D. (författare)
- Brigham and Women's Hospital / Harvard Medical School,Harvard University
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- Lee, I-Min (författare)
- Brigham and Women's Hospital / Harvard Medical School,Harvard University
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- Gaziano, J. Michael (författare)
- Umeå University
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- Yuan, Jian-Min (författare)
- University of Pittsburgh
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- Bolton, Judith Hoffman (författare)
- Johns Hopkins Bloomberg School of Public Health
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- Buring, Julie E. (författare)
- Harvard University,Brigham and Women's Hospital / Harvard Medical School
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- Visvanathan, Kala (författare)
- Johns Hopkins Bloomberg School of Public Health
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Le Marchand, Loic (författare)
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- Purdue, Mark P. (författare)
- National Cancer Institute, USA,Fred Hutchinson Cancer Research Center
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- Caporaso, Neil E. (författare)
- National Cancer Institute, USA
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- Midttun, Oivind (författare)
- Bevital AS
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- Ueland, Per M. (författare)
- University of Bergen,Haukeland University Hospital
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- Prentice, Ross L. (författare)
- University of Bergen,Haukeland University Hospital
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- Weinstein, Stephanie J. (författare)
- National Cancer Institute, USA
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- Stevens, Victoria L. (författare)
- American Cancer Society
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- Zheng, Wei (författare)
- Vanderbilt University
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- Blot, William J. (författare)
- Vanderbilt University
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- Shu, Xiao-Ou (författare)
- Vanderbilt University
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- Zhang, Xuehong (författare)
- Brigham and Women's Hospital / Harvard Medical School
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- Xiang, Yong-Bing (författare)
- Renji Hospital
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- Koh, Woon-Puay (författare)
- Duke–NUS Medical School
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- Hveem, Kristian (författare)
- Italian Institute for Genomic Medicine (IIGM)
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Thomson, Cynthia A. (författare)
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Pettinger, Mary (författare)
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- Engström, Gunnar (författare)
- Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups
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- Brunnström, Hans (författare)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Förbättrad diagnostik och prognostik vid lungcancer och metastaser till lunga,Forskargrupper vid Lunds universitet,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Improved diagnostics and prognostics of lung cancer and metastases to the lungs,Lund University Research Groups,Region Skåne
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- Milne, Roger L. (författare)
- University of Melbourne,Cancer Council Victoria
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- Stampfer, Meir J. (författare)
- Harvard University,Brigham and Women's Hospital / Harvard Medical School
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Han, Jiali (författare)
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- Johansson, Mikael (författare)
- Umeå universitet,Onkologi
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- Brennan, Paul (författare)
- International Agency for Research on Cancer, World Health Organization
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- Severi, Gianluca (författare)
- Versailles Saint-Quentin-en-Yvelines University,Cancer Council Victoria
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- Johansson, Mattias (författare)
- International Agency for Research on Cancer, World Health Organization
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(creator_code:org_t)
- 2019-01-03
- 2019
- Engelska.
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Ingår i: The BMJ. - : BMJ Publishing Group Ltd. - 1756-1833 .- 0959-8138. ; 364
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://www.bmj.com/...
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Objectives To conduct a comprehensive analysis of prospectively measured circulating high sensitivity C reactive protein (hsCRP) concentration and risk of lung cancer overall, by smoking status (never, former, and current smokers), and histological sub-type.Design Nested case-control study.Setting 20 population based cohort studies in Asia, Europe, Australia, and the United States.Participants 5299 patients with incident lung cancer, with individually incidence density matched controls.Exposure Circulating hsCRP concentrations in prediagnostic serum or plasma samples.Main outcome measure Incident lung cancer diagnosis.Results A positive association between circulating hsCRP concentration and the risk of lung cancer for current (odds ratio associated with a doubling in hsCRP concentration 1.09, 95% confidence interval 1.05 to 1.13) and former smokers (1.09, 1.04 to 1.14) was observed, but not for never smokers (P<0.01 for interaction). This association was strong and consistent across all histological subtypes, except for adenocarcinoma, which was not strongly associated with hsCRP concentration regardless of smoking status (odds ratio for adenocarcinoma overall 0.97, 95% confidence interval 0.94 to 1.01). The association between circulating hsCRP concentration and the risk of lung cancer was strongest in the first two years of follow-up for former and current smokers. Including hsCRP concentration in a risk model, in addition to smoking based variables, did not improve risk discrimination overall, but slightly improved discrimination for cancers diagnosed in the first two years of follow-up.Conclusions Former and current smokers with higher circulating hsCRP concentrations had a higher risk of lung cancer overall. Circulating hsCRP concentration was not associated with the risk of lung adenocarcinoma. Circulating hsCRP concentration could be a prediagnostic marker of lung cancer rather than a causal risk factor.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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The BMJ
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Till lärosätets databas
- Av författaren/redakt...
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Muller, David C.
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Larose, Tricia L ...
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Hodge, Allison
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Guida, Florence
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Langhammer, Arnu ...
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Grankvist, Kjell
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visa fler...
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Meyer, Klaus
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Cai, Qiuyin
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Arslan, Alan A.
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Zeleniuch-Jacquo ...
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Albanes, Demetri ...
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Giles, Graham G.
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Sesso, Howard D.
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Lee, I-Min
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Gaziano, J. Mich ...
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Yuan, Jian-Min
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Bolton, Judith H ...
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Buring, Julie E.
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Visvanathan, Kal ...
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Le Marchand, Loi ...
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Purdue, Mark P.
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Caporaso, Neil E ...
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Midttun, Oivind
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Ueland, Per M.
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Prentice, Ross L ...
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Weinstein, Steph ...
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Stevens, Victori ...
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Zheng, Wei
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Blot, William J.
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Shu, Xiao-Ou
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Zhang, Xuehong
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Xiang, Yong-Bing
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Koh, Woon-Puay
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Hveem, Kristian
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Thomson, Cynthia ...
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Pettinger, Mary
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Engström, Gunnar
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Brunnström, Hans
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Milne, Roger L.
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Stampfer, Meir J ...
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Han, Jiali
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Johansson, Mikae ...
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Brennan, Paul
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Severi, Gianluca
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Johansson, Matti ...
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Umeå universitet
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Lunds universitet