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Severe asthma among...
Severe asthma among adults : Prevalence and clinical characteristics
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- Backman, Helena (author)
- Umeå universitet,Yrkes- och miljömedicin
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- Jansson, Sven-Arne (author)
- Umeå universitet,Yrkes- och miljömedicin
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Stridsman, Caroline (author)
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Eriksson, Berne (author)
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- Hedman, Linnea (author)
- Umeå universitet,Yrkes- och miljömedicin
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- Eklund, Britt-Marie (author)
- Umeå universitet,Yrkes- och miljömedicin
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- Sandström, Thomas, 1957- (author)
- Umeå universitet,Medicin
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- Lindberg, Anne (author)
- Umeå universitet,Medicin
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Lundback, Bo (author)
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- Rönmark, Eva (author)
- Umeå universitet,Yrkes- och miljömedicin
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(creator_code:org_t)
- European Respiratory Society, 2018
- 2018
- English.
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In: European Respiratory Journal. - : European Respiratory Society. - 0903-1936 .- 1399-3003. ; 52
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Background: Severe asthma is a considerable challenge for patients, health care professionals and society. Few studies have estimated the prevalence of severe asthma according to modern definitions of which none based on a population study.Methods: We estimated the prevalence and studied characteristics of severe asthma in a large adult population-based asthma cohort followed for 10-28 years in northern Sweden: 1006 subjects participated in a follow-up during 2012-14, when 830 (82.5%) still had current asthma (mean age 59y, 32-92y, 56% women). Severe asthma was defined according to three internationally well-known criteria: the US SARP, ATS/ERS and GINA. All subjects with severe asthma were undergoing respiratory specialist care, and were also contacted by telephone to verify adherence to treatment.Results: The prevalence of severe asthma according to the three definitions was 3.6% (US SARP), 4.8% (ERS/ATS), and 6.1% (GINA) among subjects with current asthma. Although all were using high ICS doses and other maintenance treatment, >40% had uncontrolled asthma and <10% had controlled asthma according to the ACT. Severe asthma was related to age >50 years, nasal polyposis, decreased FEV1, not fully reversible airway obstruction, sensitization to aspergillus, elevated neutrophils and partly to eosinophils, and tended to be more common in women.Conclusion: The prevalence of severe asthma in this asthma cohort was 4-6%, corresponding to approximately 0.5% of the population in northern Sweden. A substantial proportion of those with severe asthma had uncontrolled disease, and severe asthma differed significantly from other asthma in terms of both clinical and inflammatory characteristics.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Publication and Content Type
- vet (subject category)
- art (subject category)
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- By the author/editor
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Backman, Helena
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Jansson, Sven-Ar ...
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Stridsman, Carol ...
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Eriksson, Berne
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Hedman, Linnea
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Eklund, Britt-Ma ...
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show more...
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Sandström, Thoma ...
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Lindberg, Anne
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Lundback, Bo
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Rönmark, Eva
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Respiratory Medi ...
- Articles in the publication
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European Respira ...
- By the university
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Umeå University