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Mid-calf skeletal m...
Mid-calf skeletal muscle density and its associations with physical activity, bone health and incident 12-month falls in older adults : The Healthy Ageing Initiative
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Elsevier,2019
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printrdacarrier
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LIBRIS-ID:oai:DiVA.org:umu-156222
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-156222URI
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https://doi.org/10.1016/j.bone.2018.12.004DOI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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BACKGROUND: Lower skeletal muscle density, indicating greater infiltration of adipose tissue into muscles, is associated with higher fracture risk in older adults. We aimed to determine whether mid-calf muscle density is associated with falls risk and bone health in community-dwelling older adults.METHODS: 2214 community-dwelling men and women who participated in the Healthy Ageing Initiative (Sweden) study at age 70 were included in this analysis. Mid-calf muscle density (mg/cm3) at the proximal tibia, and volumetric bone mineral density (vBMD) and architecture at the distal and proximal tibia and radius, were assessed by peripheral quantitative computed tomography. Whole-body lean and fat mass, lumbar spine and total hip areal bone mineral density (aBMD) were assessed by dual-energy X-ray absorptiometry. Participants completed seven-day accelerometer measurements of physical activity intensity, and self-reported falls data were collected 6 and 12 months later.RESULTS: 302 (13.5%) participants reported a fall at the 6- or 12-month interview, and 29 (1.3%) reported a fall at both interviews. After adjustment for confounders, each standard deviation decrease in mid-calf muscle density was associated with a trend towards greater likelihood of experiencing a fall (OR 1.13; 95% CI 1.00, 1.29 per SD lower) and significantly greater likelihood of multiple falls (1.61; 1.16, 2.23). Higher muscle density was not associated with total hip aBMD, and was associated with lower lumbar spine aBMD (B = -0.003; 95% CI -0.005, -0.001 per mg/cm3) and higher proximal cortical vBMD (0.74; 0.20, 1.28) at the radius. At the tibia, muscle density was positively associated with distal total and trabecular vBMD, and proximal total and cortical vBMD, cortical thickness, cortical area and stress-strain index (all P < 0.05). Only moderate/vigorous (%) intensity physical activity, not sedentary time or light activity, was associated with higher mid-calf muscle density (0.086; 0.034, 0.138).CONCLUSIONS: Lower mid-calf muscle density is independently associated with higher likelihood for multiple incident falls and appears to have localised negative effects on bone structure in older adults.
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Johansson, Jonas,1984-Umeå universitet,Yrkes- och miljömedicin(Swepub:umu)jojo0014
(author)
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McMillan, Lachlan B
(author)
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Ebeling, Peter R
(author)
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Nordström, AnnaUmeå universitet,Yrkes- och miljömedicin,School of Sport Sciences, UiT The Arctic University of Norway, Tromsø, Norway.(Swepub:umu)anagun97
(author)
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Nordström, PeterUmeå universitet,Geriatrik(Swepub:umu)peno0014
(author)
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Umeå universitetYrkes- och miljömedicin
(creator_code:org_t)
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In:Bone: Elsevier120, s. 446-4518756-32821873-2763
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