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Meta-analysis of up...
Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci
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- Erzurumluoglu, A. Mesut (author)
- University of Leicester
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Liu, Mengzhen (author)
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Jackson, Victoria E. (author)
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show more...
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Barnes, Daniel R. (author)
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Datta, Gargi (author)
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Melbourne, Carl A. (author)
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Young, Robin (author)
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Batini, Chiara (author)
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Surendran, Praveen (author)
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Jiang, Tao (author)
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Adnan, Sheikh Daud (author)
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Afaq, Saima (author)
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Agrawal, Arpana (author)
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Altmaier, Elisabeth (author)
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Antoniou, Antonis C. (author)
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Asselbergs, Folkert W. (author)
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Baumbach, Clemens (author)
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Bierut, Laura (author)
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Bertelsen, Sarah (author)
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Boehnke, Michael (author)
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Bots, Michiel L (author)
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Brazel, David M (author)
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Chambers, John C (author)
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Chang-Claude, Jenny (author)
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Chen, Chu (author)
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Corley, Janie (author)
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Chou, Yi-Ling (author)
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David, Sean P (author)
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de Boer, Rudolf A (author)
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de Leeuw, Christiaan A (author)
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Dennis, Joe G (author)
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Dominiczak, Anna F (author)
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Dunning, Alison M (author)
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Easton, Douglas F (author)
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Eaton, Charles (author)
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Elliott, Paul (author)
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Evangelou, Evangelos (author)
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Faul, Jessica D (author)
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Foroud, Tatiana (author)
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Goate, Alison (author)
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Gong, Jian (author)
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Grabe, Hans J (author)
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Haessler, Jeff (author)
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Haiman, Christopher (author)
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- Hallmans, Göran, 1947- (author)
- Umeå universitet,Näringsforskning
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Hammerschlag, Anke R (author)
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Harris, Sarah E (author)
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Hattersley, Andrew (author)
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Heath, Andrew (author)
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Hsu, Chris (author)
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Iacono, William G (author)
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Kanoni, Stavroula (author)
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Kapoor, Manav (author)
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Kaprio, Jaakko (author)
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Kardia, Sharon L (author)
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Karpe, Fredrik (author)
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Kontto, Jukka (author)
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Kooner, Jaspal S (author)
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Kooperberg, Charles (author)
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Kuulasmaa, Kari (author)
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Laakso, Markku (author)
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Lai, Dongbing (author)
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Langenberg, Claudia (author)
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Le, Nhung (author)
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Lettre, Guillaume (author)
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Loukola, Anu (author)
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Luan, Jian'an (author)
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Madden, Pamela A F (author)
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- Mangino, Massimo (author)
- University of Cambridge
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Marioni, Riccardo E (author)
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Marouli, Eirini (author)
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Marten, Jonathan (author)
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Martin, Nicholas G (author)
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McGue, Matt (author)
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Michailidou, Kyriaki (author)
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Mihailov, Evelin (author)
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Moayyeri, Alireza (author)
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Moitry, Marie (author)
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Müller-Nurasyid, Martina (author)
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Naheed, Aliya (author)
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Nauck, Matthias (author)
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Neville, Matthew J (author)
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Nielsen, Sune Fallgaard (author)
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North, Kari (author)
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Perola, Markus (author)
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Pharoah, Paul D P (author)
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Pistis, Giorgio (author)
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Polderman, Tinca J (author)
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Posthuma, Danielle (author)
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Poulter, Neil (author)
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Qaiser, Beenish (author)
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Rasheed, Asif (author)
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Reiner, Alex (author)
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- Renstrom, Frida (author)
- Umeå University,Lund University,Lunds universitet,Umeå universitet,Enheten för biobanksforskning,Genetic and Molecular Epidemiology Unit, Lund University,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Skåne University Hospital
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Rice, John (author)
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Rohde, Rebecca (author)
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- Rolandsson, Olov (author)
- Umeå universitet,Allmänmedicin
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Samani, Nilesh J (author)
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Samuel, Maria (author)
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Schlessinger, David (author)
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Scholte, Steven H (author)
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Scott, Robert A (author)
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Sever, Peter (author)
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Shao, Yaming (author)
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Shrine, Nick (author)
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Smith, Jennifer A (author)
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Starr, John M (author)
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Stirrups, Kathleen (author)
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Stram, Danielle (author)
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Stringham, Heather M (author)
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Tachmazidou, Ioanna (author)
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Tardif, Jean-Claude (author)
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Thompson, Deborah J (author)
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Tindle, Hilary A (author)
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Tragante, Vinicius (author)
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Trompet, Stella (author)
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Turcot, Valerie (author)
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Tyrrell, Jessica (author)
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Vaartjes, Ilonca (author)
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van der Leij, Andries R (author)
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van der Meer, Peter (author)
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- V. Varga, Tibor (author)
- Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups
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Verweij, Niek (author)
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Völzke, Henry (author)
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Wareham, Nicholas J (author)
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Warren, Helen R (author)
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Weir, David R (author)
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Weiss, Stefan (author)
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Wetherill, Leah (author)
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Yaghootkar, Hanieh (author)
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Yavas, Ersin (author)
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Jiang, Yu (author)
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Chen, Fang (author)
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Zhan, Xiaowei (author)
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Zhang, Weihua (author)
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- Zhao, Wei (author)
- Department of Biostatistics and Epidemiology, University of Pennsylvania, Pennsylvania, PA, USA
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- Zhao, Wei (author)
- Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA
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Zhou, Kaixin (author)
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Amouyel, Philippe (author)
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Blankenberg, Stefan (author)
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Caulfield, Mark J (author)
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Chowdhury, Rajiv (author)
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Cucca, Francesco (author)
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Deary, Ian J (author)
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Deloukas, Panos (author)
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Di Angelantonio, Emanuele (author)
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Ferrario, Marco (author)
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Ferrières, Jean (author)
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- Franks, Paul (author)
- Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Skåne University Hospital,Harvard T.H. Chan School of Public Health
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Frayling, Tim M (author)
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Frossard, Philippe (author)
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Hall, Ian P (author)
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Hayward, Caroline (author)
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- Jansson, Jan-Håkan (author)
- Umeå universitet,Avdelningen för medicin,Department of Public Health and Clinical Medicine, Skellefteå Research Unit, Umeå University, Umeå, Sweden.
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Jukema, J Wouter (author)
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Kee, Frank (author)
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Männistö, Satu (author)
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Metspalu, Andres (author)
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Munroe, Patricia B (author)
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Nordestgaard, Børge Grønne (author)
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Palmer, Colin N A (author)
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Salomaa, Veikko (author)
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Sattar, Naveed (author)
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Spector, Timothy (author)
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Strachan, David Peter (author)
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van der Harst, Pim (author)
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Zeggini, Eleftheria (author)
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Saleheen, Danish (author)
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Butterworth, Adam S (author)
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Wain, Louise V (author)
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Abecasis, Goncalo R (author)
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- Danesh, John (author)
- Pennsylvania State University College of Medicine
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Tobin, Martin D (author)
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Vrieze, Scott (author)
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Liu, Dajiang J (author)
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Howson, Joanna M M (author)
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(creator_code:org_t)
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- 2019-01-07
- 2020
- English.
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In: Molecular Psychiatry. - : Nature Publishing Group. - 1359-4184 .- 1476-5578. ; 25:10, s. 2392-2409
- Related links:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://www.nature.c...
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Subject headings
Close
- Smoking is a major heritable and modifiable risk factor for many diseases, including cancer, common respiratory disorders and cardiovascular diseases. Fourteen genetic loci have previously been associated with smoking behaviour-related traits. We tested up to 235,116 single nucleotide variants (SNVs) on the exome-array for association with smoking initiation, cigarettes per day, pack-years, and smoking cessation in a fixed effects meta-analysis of up to 61 studies (up to 346,813 participants). In a subset of 112,811 participants, a further one million SNVs were also genotyped and tested for association with the four smoking behaviour traits. SNV-trait associations with P < 5 × 10-8 in either analysis were taken forward for replication in up to 275,596 independent participants from UK Biobank. Lastly, a meta-analysis of the discovery and replication studies was performed. Sixteen SNVs were associated with at least one of the smoking behaviour traits (P < 5 × 10-8) in the discovery samples. Ten novel SNVs, including rs12616219 near TMEM182, were followed-up and five of them (rs462779 in REV3L, rs12780116 in CNNM2, rs1190736 in GPR101, rs11539157 in PJA1, and rs12616219 near TMEM182) replicated at a Bonferroni significance threshold (P < 4.5 × 10-3) with consistent direction of effect. A further 35 SNVs were associated with smoking behaviour traits in the discovery plus replication meta-analysis (up to 622,409 participants) including a rare SNV, rs150493199, in CCDC141 and two low-frequency SNVs in CEP350 and HDGFRP2. Functional follow-up implied that decreased expression of REV3L may lower the probability of smoking initiation. The novel loci will facilitate understanding the genetic aetiology of smoking behaviour and may lead to the identification of potential drug targets for smoking prevention and/or cessation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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Erzurumluoglu, A ...
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Liu, Mengzhen
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Jackson, Victori ...
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Barnes, Daniel R ...
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Datta, Gargi
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Melbourne, Carl ...
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Young, Robin
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Batini, Chiara
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Surendran, Prave ...
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Jiang, Tao
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Adnan, Sheikh Da ...
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Afaq, Saima
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Agrawal, Arpana
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Altmaier, Elisab ...
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Antoniou, Antoni ...
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Asselbergs, Folk ...
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Baumbach, Clemen ...
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Bierut, Laura
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Bertelsen, Sarah
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Boehnke, Michael
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Bots, Michiel L
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Brazel, David M
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Chambers, John C
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Chang-Claude, Je ...
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Chen, Chu
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Corley, Janie
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Chou, Yi-Ling
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David, Sean P
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de Boer, Rudolf ...
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de Leeuw, Christ ...
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Dennis, Joe G
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Dominiczak, Anna ...
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Dunning, Alison ...
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Easton, Douglas ...
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Eaton, Charles
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Elliott, Paul
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Evangelou, Evang ...
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Faul, Jessica D
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Foroud, Tatiana
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Goate, Alison
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Gong, Jian
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Grabe, Hans J
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Haessler, Jeff
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Haiman, Christop ...
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Hallmans, Göran, ...
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Hammerschlag, An ...
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Harris, Sarah E
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Hattersley, Andr ...
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Heath, Andrew
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Hsu, Chris
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Iacono, William ...
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Kanoni, Stavroul ...
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Kapoor, Manav
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Kaprio, Jaakko
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Kardia, Sharon L
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Karpe, Fredrik
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Kontto, Jukka
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Kooner, Jaspal S
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Kooperberg, Char ...
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Kuulasmaa, Kari
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Laakso, Markku
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Lai, Dongbing
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Langenberg, Clau ...
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Le, Nhung
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Lettre, Guillaum ...
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Loukola, Anu
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Luan, Jian'an
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Madden, Pamela A ...
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Mangino, Massimo
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Marioni, Riccard ...
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Marouli, Eirini
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Marten, Jonathan
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Martin, Nicholas ...
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McGue, Matt
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Michailidou, Kyr ...
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Mihailov, Evelin
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Moayyeri, Alirez ...
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Moitry, Marie
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Müller-Nurasyid, ...
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Naheed, Aliya
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Nauck, Matthias
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Neville, Matthew ...
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Nielsen, Sune Fa ...
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North, Kari
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Perola, Markus
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Pharoah, Paul D ...
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Pistis, Giorgio
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Polderman, Tinca ...
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Posthuma, Daniel ...
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Poulter, Neil
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Qaiser, Beenish
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Rasheed, Asif
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Reiner, Alex
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Renstrom, Frida
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Rice, John
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Rohde, Rebecca
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Rolandsson, Olov
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Samani, Nilesh J
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Samuel, Maria
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Schlessinger, Da ...
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Scholte, Steven ...
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Scott, Robert A
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Sever, Peter
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Shao, Yaming
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Shrine, Nick
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Smith, Jennifer ...
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Starr, John M
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Stirrups, Kathle ...
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Stram, Danielle
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Stringham, Heath ...
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Tachmazidou, Ioa ...
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Tardif, Jean-Cla ...
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Thompson, Debora ...
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Tindle, Hilary A
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Tragante, Vinici ...
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Trompet, Stella
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Turcot, Valerie
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Tyrrell, Jessica
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Vaartjes, Ilonca
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van der Leij, An ...
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van der Meer, Pe ...
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V. Varga, Tibor
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Verweij, Niek
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Völzke, Henry
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Wareham, Nichola ...
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Warren, Helen R
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Weir, David R
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Weiss, Stefan
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Wetherill, Leah
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Yaghootkar, Hani ...
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Yavas, Ersin
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Jiang, Yu
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Chen, Fang
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Zhan, Xiaowei
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Zhang, Weihua
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Zhao, Wei
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Zhou, Kaixin
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Amouyel, Philipp ...
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Blankenberg, Ste ...
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Caulfield, Mark ...
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Chowdhury, Rajiv
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Cucca, Francesco
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Deary, Ian J
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Deloukas, Panos
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Di Angelantonio, ...
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Ferrario, Marco
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Ferrières, Jean
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Franks, Paul
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Frayling, Tim M
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Frossard, Philip ...
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Hall, Ian P
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Hayward, Carolin ...
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Jansson, Jan-Håk ...
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Jukema, J Wouter
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Kee, Frank
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Männistö, Satu
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Metspalu, Andres
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Munroe, Patricia ...
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Nordestgaard, Bø ...
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Palmer, Colin N ...
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Salomaa, Veikko
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Sattar, Naveed
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Spector, Timothy
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Strachan, David ...
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van der Harst, P ...
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Zeggini, Elefthe ...
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Saleheen, Danish
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Butterworth, Ada ...
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Wain, Louise V
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Abecasis, Goncal ...
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Danesh, John
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Tobin, Martin D
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Vrieze, Scott
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Liu, Dajiang J
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Howson, Joanna M ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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Molecular Psychi ...
- By the university
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Umeå University
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Lund University