Search: (WFRF:(Zhang Yong)) pers:(Brennan Paul) pers:(Grankvist Kjell) >
Circulating cotinin...
-
Larose, Tricia L.Norwegian University of Science and Technology,International Agency for Research on Cancer, World Health Organization
(author)
Circulating cotinine concentrations and lung cancer risk in the Lung Cancer Cohort Consortium (LC3)
- Article/chapterEnglish2018
Publisher, publication year, extent ...
-
2018-06-12
-
Oxford University Press,2018
-
printrdacarrier
Numbers
-
LIBRIS-ID:oai:DiVA.org:umu-156619
-
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-156619URI
-
https://doi.org/10.1093/ije/dyy100DOI
-
https://lup.lub.lu.se/record/1a1191da-5a07-470b-b6e0-32cf5c341afaURI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
Background: Self-reported smoking is the principal measure used to assess lung cancer risk in epidemiological studies. We evaluated if circulating cotinine—a nicotine metabolite and biomarker of recent tobacco exposure—provides additional information on lung cancer risk.Methods: The study was conducted in the Lung Cancer Cohort Consortium (LC3) involving 20 prospective cohort studies. Pre-diagnostic serum cotinine concentrations were measured in one laboratory on 5364 lung cancer cases and 5364 individually matched controls. We used conditional logistic regression to evaluate the association between circulating cotinine and lung cancer, and assessed if cotinine provided additional risk-discriminative information compared with self-reported smoking (smoking status, smoking intensity, smoking duration), using receiver-operating characteristic (ROC) curve analysis.Results: We observed a strong positive association between cotinine and lung cancer risk for current smokers [odds ratio (OR ) per 500 nmol/L increase in cotinine (OR500): 1.39, 95% confidence interval (CI): 1.32–1.47]. Cotinine concentrations consistent with active smoking (≥115 nmol/L) were common in former smokers (cases: 14.6%; controls: 9.2%) and rare in never smokers (cases: 2.7%; controls: 0.8%). Former and never smokers with cotinine concentrations indicative of active smoking (≥115 nmol/L) also showed increased lung cancer risk. For current smokers, the risk-discriminative performance of cotinine combined with self-reported smoking (AUCintegrated: 0.69, 95% CI: 0.68–0.71) yielded a small improvement over self-reported smoking alone (AUCsmoke: 0.66, 95% CI: 0.64–0.68) (P = 1.5x10–9).Conclusions: Circulating cotinine concentrations are consistently associated with lung cancer risk for current smokers and provide additional risk-discriminative information compared with self-report smoking alone.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Guida, Florence
(author)
-
Fanidi, Anouar
(author)
-
Langhammer, Arnulf
(author)
-
Kveem, Kristian
(author)
-
Stevens, Victoria L.
(author)
-
Jacobs, Eric J.
(author)
-
Smith-Warner, Stephanie A.
(author)
-
Giovannucci, Edward
(author)
-
Albanes, Demetrius
(author)
-
Weinstein, Stephanie J.
(author)
-
Freedman, Neal D.
(author)
-
Prentice, Ross
(author)
-
Pettinger, Mary
(author)
-
Thomson, Cynthia A.
(author)
-
Cai, Qiuyin
(author)
-
Wu, Jie
(author)
-
Blot, William J.
(author)
-
Arslan, Alan A.
(author)
-
Zeleniuch-Jacquotte, Anne
(author)
-
Le Marchand, Loic
(author)
-
Wilkens, Lynne R.
(author)
-
Haiman, Christopher A.
(author)
-
Zhang, Xuehong
(author)
-
Stampfer, Meir J.
(author)
-
Hodge, Allison M.
(author)
-
Giles, Graham G.
(author)
-
Severi, Gianluca
(author)
-
Johansson, MikaelUmeå universitet,Onkologi(Swepub:umu)mijo0025
(author)
-
Grankvist, KjellUmeå universitet,Klinisk kemi(Swepub:umu)kjgr0002
(author)
-
Wang, Renwei
(author)
-
Yuan, Jian-Min
(author)
-
Gao, Yu-Tang
(author)
-
Koh, Woon-Puay
(author)
-
Shu, Xiao-Ou
(author)
-
Zheng, Wei
(author)
-
Xiang, Yong-Bing
(author)
-
Li, Honglan
(author)
-
Lan, Qing
(author)
-
Visvanathan, Kala
(author)
-
Bolton, Judith Hoffman
(author)
-
Ueland, Per Magne
(author)
-
Midttun, Oivind
(author)
-
Caporaso, Neil
(author)
-
Purdue, Mark
(author)
-
Sesso, Howard D.
(author)
-
Buring, Julie E.
(author)
-
Lee, I-Min
(author)
-
Gaziano, J. Michael
(author)
-
Manjer, JonasLund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups,Skåne University Hospital(Swepub:lu)smi-jma
(author)
-
Brunnström, HansLund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Förbättrad diagnostik och prognostik vid lungcancer och metastaser till lunga,Forskargrupper vid Lunds universitet,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Improved diagnostics and prognostics of lung cancer and metastases to the lungs,Lund University Research Groups,Regional Laboratories Region Skåne(Swepub:lu)med-hsb
(author)
-
Brennan, Paul
(author)
-
Johansson, MattiasInternational Agency for Research on Cancer, World Health Organization
(author)
-
Norwegian University of Science and TechnologyInternational Agency for Research on Cancer, World Health Organization
(creator_code:org_t)
-
Lung Cancer Cohort Consortium
Related titles
-
In:International Journal of Epidemiology: Oxford University Press47:6, s. 1760-17710300-57711464-3685
Internet link
Find in a library
To the university's database
- By the author/editor
-
Larose, Tricia L ...
-
Guida, Florence
-
Fanidi, Anouar
-
Langhammer, Arnu ...
-
Kveem, Kristian
-
Stevens, Victori ...
-
show more...
-
Jacobs, Eric J.
-
Smith-Warner, St ...
-
Giovannucci, Edw ...
-
Albanes, Demetri ...
-
Weinstein, Steph ...
-
Freedman, Neal D ...
-
Prentice, Ross
-
Pettinger, Mary
-
Thomson, Cynthia ...
-
Cai, Qiuyin
-
Wu, Jie
-
Blot, William J.
-
Arslan, Alan A.
-
Zeleniuch-Jacquo ...
-
Le Marchand, Loi ...
-
Wilkens, Lynne R ...
-
Haiman, Christop ...
-
Zhang, Xuehong
-
Stampfer, Meir J ...
-
Hodge, Allison M ...
-
Giles, Graham G.
-
Severi, Gianluca
-
Johansson, Mikae ...
-
Grankvist, Kjell
-
Wang, Renwei
-
Yuan, Jian-Min
-
Gao, Yu-Tang
-
Koh, Woon-Puay
-
Shu, Xiao-Ou
-
Zheng, Wei
-
Xiang, Yong-Bing
-
Li, Honglan
-
Lan, Qing
-
Visvanathan, Kal ...
-
Bolton, Judith H ...
-
Ueland, Per Magn ...
-
Midttun, Oivind
-
Caporaso, Neil
-
Purdue, Mark
-
Sesso, Howard D.
-
Buring, Julie E.
-
Lee, I-Min
-
Gaziano, J. Mich ...
-
Manjer, Jonas
-
Brunnström, Hans
-
Brennan, Paul
-
Johansson, Matti ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Health Sciences
-
and Public Health Gl ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cancer and Oncol ...
- Articles in the publication
-
International Jo ...
- By the university
-
Umeå University
-
Lund University