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Registration of his...
Registration of histopathology to magnetic resonance imaging of prostate cancer
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- Sandgren, Kristina (författare)
- Umeå universitet,Radiofysik
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- Nilsson, Erik (författare)
- Umeå universitet,Radiofysik
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- Keeratijarut Lindberg, Angsana (författare)
- Umeå universitet,Radiofysik
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- Strandberg, Sara, 1976- (författare)
- Umeå universitet,Diagnostisk radiologi
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- Blomqvist, Lennart (författare)
- Karolinska Institutet
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- Bergh, Anders (författare)
- Umeå universitet,Patologi
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- Friedrich, Bengt (författare)
- Umeå universitet,Urologi och andrologi
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- Axelsson, Jan, 1966- (författare)
- Umeå universitet,Radiofysik
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- Ögren, Margareta (författare)
- Umeå universitet,Diagnostisk radiologi
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- Ögren, Mattias (författare)
- Umeå universitet,Diagnostisk radiologi
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- Widmark, Anders (författare)
- Umeå universitet,Onkologi
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- Thellenberg-Karlsson, Camilla, 1972- (författare)
- Umeå universitet,Onkologi
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- Söderström, Karin (författare)
- Umeå universitet,Onkologi
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- Riklund, Katrine, MD, PhD, Professor, 1963- (författare)
- Umeå universitet,Diagnostisk radiologi
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- Jonsson, Joakim, 1984- (författare)
- Umeå universitet,Radiofysik
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- Nyholm, Tufve (författare)
- Umeå universitet,Radiofysik
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Söderkvist, K (författare)
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(creator_code:org_t)
- Elsevier, 2021
- 2021
- Engelska.
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Ingår i: Physics and Imaging in Radiation Oncology. - : Elsevier. - 2405-6316. ; 18, s. 19-25
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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http://phiro.science...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background and purpose: The diagnostic accuracy of new imaging techniques requires validation, preferably by histopathological verification. The aim of this study was to develop and present a registration procedure between histopathology and in-vivo magnetic resonance imaging (MRI) of the prostate, to estimate its uncertainty and to evaluate the benefit of adding a contour-correcting registration.Materials and methods: For twenty-five prostate cancer patients, planned for radical prostatectomy, a 3D-printed prostate mold based on in-vivo MRI was created and an ex-vivo MRI of the specimen, placed inside the mold, was performed. Each histopathology slice was registered to its corresponding ex-vivo MRI slice using a 2D-affine registration. The ex-vivo MRI was rigidly registered to the in-vivo MRI and the resulting transform was applied to the histopathology stack. A 2D deformable registration was used to correct for specimen distortion concerning the specimen's fit inside the mold. We estimated the spatial uncertainty by comparing positions of landmarks in the in-vivo MRI and the corresponding registered histopathology stack.Results: Eighty-four landmarks were identified, located in the urethra (62%), prostatic cysts (33%), and the ejaculatory ducts (5%). The median number of landmarks was 3 per patient. We showed a median in-plane error of 1.8 mm before and 1.7 mm after the contour-correcting deformable registration. In patients with extraprostatic margins, the median in-plane error improved from 2.1 mm to 1.8 mm after the contour-correcting deformable registration.Conclusions: Our registration procedure accurately registers histopathology to in-vivo MRI, with low uncertainty. The contour-correcting registration was beneficial in patients with extraprostatic surgical margins.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Nyckelord
- Histopathology correlation
- Image registration
- PET/MRI
- Prostate cancer
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Sandgren, Kristi ...
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Nilsson, Erik
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Keeratijarut Lin ...
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Strandberg, Sara ...
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Blomqvist, Lenna ...
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Bergh, Anders
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Friedrich, Bengt
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Axelsson, Jan, 1 ...
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Ögren, Margareta
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Ögren, Mattias
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Widmark, Anders
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Thellenberg-Karl ...
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Söderström, Kari ...
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Riklund, Katrine ...
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Jonsson, Joakim, ...
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Nyholm, Tufve
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Söderkvist, K
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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Physics and Imag ...
- Av lärosätet
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Umeå universitet
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Karolinska Institutet