Search: (WFRF:(Ferrieres Jean)) pers:(Wareham Nicholas J) pers:(Lindgren Cecilia M.) >
Protein-coding vari...
Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution
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- Justice, Anne E. (author)
- University of North Carolina,Geisinger Health System
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Karaderi, Tugce (author)
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Highland, Heather M. (author)
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show more...
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- Lind, Lars (author)
- Uppsala universitet,Klinisk epidemiologi
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Graff, Mariaelisa (author)
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Lu, Yingchang (author)
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Turcot, Valerie (author)
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Auer, Paul L. (author)
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Fine, Rebecca S. (author)
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Guo, Xiuqing (author)
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Schurmann, Claudia (author)
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Lempradl, Adelheid (author)
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Marouli, Eirini (author)
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Mahajan, Anubha (author)
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Winkler, Thomas W. (author)
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Locke, Adam E. (author)
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Medina-Gomez, Carolina (author)
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Esko, Tonu (author)
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Vedantam, Sailaja (author)
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Giri, Ayush (author)
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Lo, Ken Sin (author)
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Alfred, Tamuno (author)
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Mudgal, Poorva (author)
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Ng, Maggie C. Y. (author)
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Heard-Costa, Nancy L. (author)
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Feitosa, Mary F. (author)
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Manning, Alisa K. (author)
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Willems, Sara M. (author)
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Sivapalaratnam, Suthesh (author)
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Abecasis, Goncalo (author)
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Alam, Dewan S. (author)
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Allison, Matthew (author)
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Amouyel, Philippe (author)
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Arzumanyanm, Zorayr (author)
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Balkau, Beverley (author)
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Bastarache, Lisa (author)
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Bergmann, Sven (author)
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Bielak, Lawrence F. (author)
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Blueher, Matthias (author)
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Boehnke, Michael (author)
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Boeing, Heiner (author)
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Boerwinkle, Eric (author)
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Boeger, Carsten A. (author)
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Bork-Jensen, Jette (author)
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Bottinger, Erwin P. (author)
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Bowden, Donald W. (author)
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Brandslund, Ivan (author)
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Broer, Linda (author)
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Burt, Amber A. (author)
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Butterworth, Adam S. (author)
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Caulfield, Markj (author)
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Cesana, Giancarlo (author)
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Chambers, John C. (author)
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Chasman, Daniel, I (author)
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Chen, Yii-Der Ida (author)
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Chowdhury, Rajiv (author)
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Christensen, Cramer (author)
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Chu, Audreyy (author)
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Collins, Francis S. (author)
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Cook, James P. (author)
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Cox, Amanda J. (author)
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Crosslin, David S. (author)
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Danesh, John (author)
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de Bakker, Paul I. W. (author)
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de Denus, Simon (author)
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de Mutsert, Renee (author)
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Dedoussis, George (author)
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Demerath, Ellen W. (author)
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Dennis, Joe G. (author)
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Denny, Josh C. (author)
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Di Angelantonio, Emanuele (author)
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Doerr, Marcus (author)
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Drenos, Fotios (author)
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Dube, Marie-Pierre (author)
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Dunning, Alison M. (author)
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Easton, Douglas F. (author)
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Elliott, Paul (author)
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- Evangelou, Evangelos (author)
- University of North Carolina
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Farmaki, Aliki-Eleni (author)
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Feng, Shuang (author)
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Ferrannini, Ele (author)
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Ferrieres, Jean (author)
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Florez, Jose C. (author)
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Fornage, Myriam (author)
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Fox, Caroline S. (author)
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- Franks, Paul W. (author)
- Umeå University,Lund University,Lunds universitet,Umeå universitet,Avdelningen för medicin,Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmo, Sweden; Department of Nutrition, Harvard School of Public Health, Boston, MA, USA,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups
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Friedrich, Nele (author)
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Gan, Wei (author)
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Gandin, Ilaria (author)
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Gasparini, Paolo (author)
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- Giedraitis, Vilmantas (author)
- Uppsala universitet,Geriatrik
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Girotto, Giorgia (author)
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Gorski, Mathias (author)
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Grallert, Harald (author)
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Grarup, Niels (author)
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Groves, Megan L. (author)
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- Gustafsson, Stefan (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Molekylär epidemiologi
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Haessler, Jeff (author)
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Hansen, Torben (author)
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Hattersley, Andrew T. (author)
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Hayward, Caroline (author)
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Heid, Iris M. (author)
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Holmen, Oddgeir L. (author)
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Hovingh, G. Kees (author)
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Howson, Joanna M. M. (author)
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Hu, Yao (author)
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Hung, Yi-Jen (author)
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Hveem, Kristian (author)
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Ikram, M. Arfan (author)
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- Ingelsson, Erik, 1975- (author)
- Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab,Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA
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Jackson, Anne U. (author)
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Jarvik, Gail P. (author)
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Jia, Yucheng (author)
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Jorgensen, Torben (author)
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Jousilahti, Pekka (author)
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Justesen, Johanne M. (author)
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Kahali, Bratati (author)
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Karaleftheri, Maria (author)
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Kardia, Sharon L. R. (author)
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Karpe, Fredrik (author)
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Kee, Frank (author)
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Kitajima, Hidetoshi (author)
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Komulainen, Pirjo (author)
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Kooner, Jaspal S. (author)
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Kovacs, Peter (author)
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Kraemer, Bernhard K. (author)
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Kuulasmaa, Kari (author)
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Kuusisto, Johanna (author)
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Laakso, Markku (author)
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Lakka, Timo A. (author)
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Lamparter, David (author)
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La Nge, Leslie A. (author)
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Langenberg, Claudia (author)
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Larson, Eric B. (author)
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Lee, Nanette R. (author)
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Lee, Wen-Jane (author)
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Lehtimaeki, Terho (author)
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Lewis, Cora E. (author)
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Li, Huaixing (author)
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Li, Jin (author)
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Lin, Li-An (author)
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Lin, Xu (author)
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Lind, Lars (author)
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Lindstroem, Jaana (author)
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Linneberg, Allan (author)
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Liu, Ching-Ti (author)
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Liu, Dajiang J. (author)
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Luan, Jian'an (author)
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Lyytikainen, Leo-Pekka (author)
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MacGregor, Stuart (author)
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Magi, Reedik (author)
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Mannisto, Satu (author)
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Marenne, Gaelle (author)
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Marten, Jonathan (author)
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Mascal, Nicholas G. D. (author)
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McCarthy, Mark, I (author)
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Meidtner, Karina (author)
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Mihailov, Evelin (author)
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Moilanen, Leena (author)
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- Moitry, Marie (author)
- University of Oxford
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Mook-Kanamori, Dennis O. (author)
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Morgan, Anna (author)
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Morris, Andrew P. (author)
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Mueller-Nurasyid, Martina (author)
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Munroe, Patricia B. (author)
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Narisu, Narisu (author)
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Nelson, Christopher P. (author)
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Neville, Matt (author)
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Ntalla, Ioanna (author)
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Owen, Katharine R. (author)
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Pedersen, Oluf (author)
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Peloso, Gina M. (author)
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Pennell, Craig E. (author)
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Perola, Markus (author)
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James, A. (author)
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Perry, John R. B. (author)
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Pers, Tune H. (author)
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Ewing, Ailith (author)
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Polasek, Ozren (author)
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Rasheed, Asif (author)
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Raulerson, Chelsea K. (author)
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Rauramaa, Rainer (author)
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Reilly, Dermot F. (author)
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Reiner, Alex P. (author)
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Ridker, Paul M. (author)
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Rivas, Manuel A. (author)
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Robertson, Neil R. (author)
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Robino, Antonietta (author)
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Rudan, Igor (author)
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Ruth, Katherine S. (author)
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Saleheen, Danish (author)
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Salomaa, Veikko (author)
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Samani, Nilesh J. (author)
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Schreiner, Pamela J. (author)
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Schulze, Matthias B. (author)
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Scott, Robert A. (author)
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Segura-Lepe, Marcelo (author)
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Sim, Xueling (author)
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Slater, Andrew J. (author)
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Small, Kerrin S. (author)
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Smith, Blair H. (author)
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Smith, Jennifer A. (author)
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Southam, Lorraine (author)
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Spector, Timothy D. (author)
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Speliotes, Elizabeth K. (author)
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Stefansson, Kari (author)
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Steinthorsdottir, Valgerdur (author)
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Stirrups, Kathleen E. (author)
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Strauch, Konstantin (author)
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Stringham, Heather M. (author)
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Stumvoll, Michael (author)
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Sun, Liang (author)
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Surendran, Praveen (author)
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Swart, Karin M. A. (author)
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Tardif, Jean-Claude (author)
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Taylor, Kent D. (author)
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Teumer, Alexander (author)
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Thompson, Deborah J. (author)
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Thorleifsson, Gudmar (author)
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Thorsteinsdottir, Unnur (author)
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Thuesen, Betina H. (author)
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Toenjes, Anke (author)
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Torres, Mina (author)
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Tsafantakis, Emmanouil (author)
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Tuomilehto, Jaakko (author)
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Uitterlinden, Andre G. (author)
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Uusitupa, Matti (author)
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van Duijn, Cornelia M. (author)
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Vanhala, Mauno (author)
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Varma, Rohit (author)
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Vermeulen, Sita H. (author)
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Vestergaard, Henrik (author)
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Vitart, Veronique (author)
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Vogt, Thomas F. (author)
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Vuckovic, Dragana (author)
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Wagenknecht, Lynne E. (author)
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Walker, Mark (author)
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- Wallentin, Lars, 1943- (author)
- Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)
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Wang, Feijie (author)
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Wang, Carol A. (author)
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Wang, Shuai (author)
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Wareham, N. Icholas J. (author)
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Warren, Helen R. (author)
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Waterworth, Dawn M. (author)
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Wessel, Jennifer (author)
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White, Harvey D. (author)
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Willer, Cristen J. (author)
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Wilson, James G. (author)
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Wood, Andrew R. (author)
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Wu, Ying (author)
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Yaghootkar, Hanieh (author)
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Yao, Jie (author)
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Verges-Armstrong, Laura M. (author)
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Young, Robin (author)
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Zeggini, Eleftheria (author)
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Zhan, Xiaowei (author)
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Zhang, Weihua (author)
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Zhao, Jing Hua (author)
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Zhao, Wei (author)
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Zheng, He (author)
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Zhou, Wei (author)
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Zillikens, M. Carola (author)
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Rivadeneira, Fernando (author)
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Borecki, Ingrid B. (author)
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Pospisilik, J. Andrew (author)
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Deloukas, Panos (author)
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Frayling, Timothy M. (author)
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Lettre, Guillaume (author)
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Mohlke, Karen L. (author)
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Rotter, Jerome, I (author)
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Kutalik, Zoltan (author)
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Hirschhorn, Joel N. (author)
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Cupples, L. Adrienne (author)
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Loos, Ruth J. F. (author)
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North, Kari E. (author)
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Lindgren, Cecilia M. (author)
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O'Connell, Jeffrey R. (author)
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Raitakari, Olli T. (author)
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Lange, Leslie A. (author)
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Uitterlinden, Andr G. (author)
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Grove, Megan L. (author)
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Masca, Nicholas G. D. (author)
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Luan, Jianan (author)
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Wareham, Nicholas J. (author)
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Esko, Tnu (author)
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De Bakker, Paul Iw (author)
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Caulfield, Mark J. (author)
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Mller-Nurasyid, Martina (author)
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(creator_code:org_t)
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et al
- 2019-02-18
- 2019
- English.
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In: Nature Genetics. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 51:3, s. 452-469
- Related links:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://lup.lub.lu.s...
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Abstract
Subject headings
Close
- Body-fat distribution is a risk factor for adverse cardiovascular health consequences. We analyzed the association of body-fat distribution, assessed by waist-to-hip ratio adjusted for body mass index, with 228,985 predicted coding and splice site variants available on exome arrays in up to 344,369 individuals from five major ancestries (discovery) and 132,177 European-ancestry individuals (validation). We identified 15 common (minor allele frequency, MAF >= 5%) and nine low-frequency or rare (MAF < 5%) coding novel variants. Pathway/gene set enrichment analyses identified lipid particle, adiponectin, abnormal white adipose tissue physiology and bone development and morphology as important contributors to fat distribution, while cross-trait associations highlight cardiometabolic traits. In functional follow-up analyses, specifically in Drosophila RNAi-knockdowns, we observed a significant increase in the total body triglyceride levels for two genes (DNAH10 and PLXND1). We implicate novel genes in fat distribution, stressing the importance of interrogating low-frequency and protein-coding variants.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Justice, Anne E.
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Karaderi, Tugce
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Highland, Heathe ...
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Lind, Lars
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Graff, Mariaelis ...
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Lu, Yingchang
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show more...
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Turcot, Valerie
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Auer, Paul L.
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Fine, Rebecca S.
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Guo, Xiuqing
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Schurmann, Claud ...
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Lempradl, Adelhe ...
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Marouli, Eirini
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Mahajan, Anubha
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Winkler, Thomas ...
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Locke, Adam E.
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Medina-Gomez, Ca ...
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Esko, Tonu
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Vedantam, Sailaj ...
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Giri, Ayush
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Lo, Ken Sin
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Alfred, Tamuno
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Mudgal, Poorva
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Ng, Maggie C. Y.
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Heard-Costa, Nan ...
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Feitosa, Mary F.
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Manning, Alisa K ...
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Willems, Sara M.
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Sivapalaratnam, ...
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Abecasis, Goncal ...
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Alam, Dewan S.
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Allison, Matthew
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Amouyel, Philipp ...
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Arzumanyanm, Zor ...
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Balkau, Beverley
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Bastarache, Lisa
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Bergmann, Sven
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Bielak, Lawrence ...
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Blueher, Matthia ...
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Boehnke, Michael
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Boeing, Heiner
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Boerwinkle, Eric
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Boeger, Carsten ...
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Bork-Jensen, Jet ...
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Bottinger, Erwin ...
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Bowden, Donald W ...
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Brandslund, Ivan
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Broer, Linda
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Burt, Amber A.
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Butterworth, Ada ...
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Caulfield, Markj
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Cesana, Giancarl ...
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Chambers, John C ...
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Chasman, Daniel, ...
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Chen, Yii-Der Id ...
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Chowdhury, Rajiv
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Christensen, Cra ...
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Chu, Audreyy
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Collins, Francis ...
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Cook, James P.
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Cox, Amanda J.
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Crosslin, David ...
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Danesh, John
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de Bakker, Paul ...
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de Denus, Simon
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de Mutsert, Rene ...
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Dedoussis, Georg ...
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Demerath, Ellen ...
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Dennis, Joe G.
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Denny, Josh C.
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Di Angelantonio, ...
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Doerr, Marcus
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Drenos, Fotios
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Dube, Marie-Pier ...
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Dunning, Alison ...
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Easton, Douglas ...
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Elliott, Paul
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Evangelou, Evang ...
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Farmaki, Aliki-E ...
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Feng, Shuang
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Ferrannini, Ele
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Ferrieres, Jean
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Florez, Jose C.
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Fornage, Myriam
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Fox, Caroline S.
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Franks, Paul W.
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Friedrich, Nele
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Gan, Wei
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Gandin, Ilaria
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Gasparini, Paolo
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Giedraitis, Vilm ...
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Girotto, Giorgia
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Gorski, Mathias
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Grallert, Harald
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Grarup, Niels
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Groves, Megan L.
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Gustafsson, Stef ...
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Haessler, Jeff
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Hansen, Torben
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Hattersley, Andr ...
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Hayward, Carolin ...
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Heid, Iris M.
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Holmen, Oddgeir ...
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Hovingh, G. Kees
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Howson, Joanna M ...
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Hu, Yao
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Hung, Yi-Jen
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Hveem, Kristian
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Ikram, M. Arfan
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Ingelsson, Erik, ...
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Jackson, Anne U.
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Jarvik, Gail P.
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Jia, Yucheng
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Jorgensen, Torbe ...
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Jousilahti, Pekk ...
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Justesen, Johann ...
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Kahali, Bratati
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Karaleftheri, Ma ...
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Kardia, Sharon L ...
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Karpe, Fredrik
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Kee, Frank
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Kitajima, Hideto ...
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Komulainen, Pirj ...
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Kooner, Jaspal S ...
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Kovacs, Peter
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Kraemer, Bernhar ...
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Kuulasmaa, Kari
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Kuusisto, Johann ...
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Laakso, Markku
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Lakka, Timo A.
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Lamparter, David
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La Nge, Leslie A ...
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Langenberg, Clau ...
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Larson, Eric B.
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Lee, Nanette R.
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Lee, Wen-Jane
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Lehtimaeki, Terh ...
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Lewis, Cora E.
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Li, Huaixing
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Li, Jin
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Lin, Li-An
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Lin, Xu
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Lindstroem, Jaan ...
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Linneberg, Allan
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Liu, Ching-Ti
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Liu, Dajiang J.
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Luan, Jian'an
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Lyytikainen, Leo ...
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MacGregor, Stuar ...
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Magi, Reedik
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Mannisto, Satu
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Marenne, Gaelle
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Marten, Jonathan
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Mascal, Nicholas ...
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McCarthy, Mark, ...
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Meidtner, Karina
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Mihailov, Evelin
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Moilanen, Leena
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Moitry, Marie
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Mook-Kanamori, D ...
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Morgan, Anna
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Morris, Andrew P ...
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Mueller-Nurasyid ...
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Munroe, Patricia ...
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Narisu, Narisu
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Nelson, Christop ...
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Neville, Matt
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Ntalla, Ioanna
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Owen, Katharine ...
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Pedersen, Oluf
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Peloso, Gina M.
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Pennell, Craig E ...
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Perola, Markus
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James, A.
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Perry, John R. B ...
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Pers, Tune H.
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Ewing, Ailith
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Polasek, Ozren
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Rasheed, Asif
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Raulerson, Chels ...
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Rauramaa, Rainer
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Reilly, Dermot F ...
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Reiner, Alex P.
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Ridker, Paul M.
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Rivas, Manuel A.
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Robertson, Neil ...
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Robino, Antoniet ...
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Rudan, Igor
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Ruth, Katherine ...
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Saleheen, Danish
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Salomaa, Veikko
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Samani, Nilesh J ...
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Schreiner, Pamel ...
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Schulze, Matthia ...
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Scott, Robert A.
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Segura-Lepe, Mar ...
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Sim, Xueling
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Slater, Andrew J ...
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Small, Kerrin S.
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Smith, Blair H.
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Smith, Jennifer ...
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Southam, Lorrain ...
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Spector, Timothy ...
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Speliotes, Eliza ...
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Stefansson, Kari
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Steinthorsdottir ...
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Stirrups, Kathle ...
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Strauch, Konstan ...
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Stringham, Heath ...
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Stumvoll, Michae ...
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Sun, Liang
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Surendran, Prave ...
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Swart, Karin M. ...
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Tardif, Jean-Cla ...
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Taylor, Kent D.
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Teumer, Alexande ...
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Thompson, Debora ...
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Thorleifsson, Gu ...
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Thorsteinsdottir ...
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Thuesen, Betina ...
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Toenjes, Anke
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Torres, Mina
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Tsafantakis, Emm ...
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Tuomilehto, Jaak ...
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Uitterlinden, An ...
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Uusitupa, Matti
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van Duijn, Corne ...
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Vanhala, Mauno
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Varma, Rohit
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Vermeulen, Sita ...
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Vestergaard, Hen ...
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Vitart, Veroniqu ...
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Vogt, Thomas F.
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Vuckovic, Dragan ...
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Wagenknecht, Lyn ...
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Walker, Mark
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Wallentin, Lars, ...
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Wang, Feijie
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Wang, Carol A.
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Wang, Shuai
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Wareham, N. Icho ...
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Warren, Helen R.
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Waterworth, Dawn ...
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Wessel, Jennifer
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White, Harvey D.
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Willer, Cristen ...
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Wilson, James G.
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Wood, Andrew R.
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Wu, Ying
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Yaghootkar, Hani ...
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Yao, Jie
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Verges-Armstrong ...
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Young, Robin
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Zeggini, Elefthe ...
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Zhan, Xiaowei
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Zhang, Weihua
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Zhao, Jing Hua
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Zhao, Wei
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Zheng, He
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Zhou, Wei
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Zillikens, M. Ca ...
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Rivadeneira, Fer ...
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Borecki, Ingrid ...
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Pospisilik, J. A ...
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Deloukas, Panos
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Frayling, Timoth ...
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Lettre, Guillaum ...
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Mohlke, Karen L.
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Rotter, Jerome, ...
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Kutalik, Zoltan
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Hirschhorn, Joel ...
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Cupples, L. Adri ...
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Loos, Ruth J. F.
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North, Kari E.
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Lindgren, Cecili ...
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O'Connell, Jeffr ...
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Raitakari, Olli ...
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Lange, Leslie A.
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Uitterlinden, An ...
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Grove, Megan L.
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Masca, Nicholas ...
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Luan, Jianan
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Wareham, Nichola ...
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Esko, Tnu
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De Bakker, Paul ...
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Caulfield, Mark ...
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Mller-Nurasyid, ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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Nature Genetics
- By the university
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Umeå University
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Uppsala University
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Lund University