Serum glucose, triglycerides, and cholesterol in relation to prostate cancer death in the Swedish AMORIS study

Arthur, RhondaAlbert Einstein Coll Med, Dept Epidemiol & Populat Hlth, New York, NY 10461 USA;Kings Coll London, Translat Oncol & Urol Res, London, England;Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, 1300 Morris Pk, Bronx, NY 10461 USA (författare)

Purpose: Lifestyle-related conditions such as obesity are associated with prostate cancer progression, but the associations with hyperglycemia and dyslipidemia are unclear. This study, therefore, aims to examine the association of glucose, triglycerides, and total cholesterol with prostate cancer death. Methods: From the Swedish AMORIS cohort, we selected 14,150 men diagnosed with prostate cancer between 1996 and 2011 who had prediagnostic measurements of serum glucose, triglycerides, and total cholesterol. Multivariable Cox proportional hazards regressionmodels were used to determine the hazard ratios for death in relation to the aforementioned metabolic markers. Results: Using clinical cut-off points, a non-significant positive association was observed between glucose and prostate cancer death. When compared to those with glucose in the lowest quartile, those in the highest quartile had greater risk of prostate cancer death (HR 1.19; 95% CI 1.02-1.39). However, neither total cholesterol nor triglycerides were associated with prostate cancer death. Glucose and triglycerides were positively associated with overall, cardiovascular, and other deaths. Hypercholesterolemia was only associated with risk of CVD death. Conclusion: Our results suggest that glucose levels may influence prostate cancer survival, but further studies using repeated measurements are needed to further elucidate how glucose levels may influence prostate cancer progression.

Møller, HenrikKings Coll London, Translat Oncol & Urol Res, London, England (författare)
Garmo, HansKings Coll London, Translat Oncol & Urol Res, London, England;Uppsala Univ Hosp, Dept Surg Sci, Uppsala, Sweden (författare)
Häggström, ChristelUppsala universitet,Umeå universitet,Enheten för biobanksforskning,Department of Surgical Sciences, Uppsala University Hospital, Uppsala, Sweden,Endokrinkirurgi,Umea Univ, Dept Biobank Res, Umea, Sweden(Swepub:uu)chrha650 (författare)
Holmberg, LarsKings Coll London, Translat Oncol & Urol Res, London, England (författare)
Stattin, PärUppsala universitet,Umeå universitet,Urologi och andrologi,Urologkirurgi(Swepub:uu)parst892 (författare)
Malmström, HåkanKarolinska Institutet (författare)
Lambe, MatsKarolinska Institutet (författare)
Hammar, NiklasKarolinska Institutet (författare)
Walldius, GöranKarolinska Institutet (författare)
Robinson, DavidRyhov Hosp, Dept Urol, Jonkoping, Sweden (författare)
Jungner, IngmarKarolinska Inst, Dept Clin Epidemiol, Stockholm, Sweden;CALAB Res, Stockholm, Sweden (författare)
Van Hemelrijck, MiekeKings Coll London, Translat Oncol & Urol Res, London, England (författare)
Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, New York, NY 10461 USA;Kings Coll London, Translat Oncol & Urol Res, London, England;Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, 1300 Morris Pk, Bronx, NY 10461 USAKings Coll London, Translat Oncol & Urol Res, London, England (creator_code:org_t)

Av författaren/redakt...: Arthur, Rhonda; Møller, Henrik; Garmo, Hans; Häggström, Chris ...; Holmberg, Lars; Stattin, Pär; visa fler...; Malmström, Håkan; Lambe, Mats; Hammar, Niklas; Walldius, Göran; Robinson, David; Jungner, Ingmar; Van Hemelrijck, ...; visa färre...

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