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Alcohol consumption...
Alcohol consumption and risk of atrial fibrillation - results from the BiomarCaRE Consortium
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Csengeri, D. (författare)
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Spruenker, N. A. (författare)
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Di Castelnuovo, A. (författare)
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visa fler...
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Niiranen, T. (författare)
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- Söderberg, Stefan (författare)
- Umeå University Hospital
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Magnussen, C. (författare)
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Lochen, M. J. (författare)
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Kee, F. (författare)
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Blankenberg, S. (författare)
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Jørgensen, T. (författare)
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Kuulasmaa, K. (författare)
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Zeller, T. (författare)
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Salomaa, V. (författare)
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Iacoviello, L. (författare)
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Schnabel, R. (författare)
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(creator_code:org_t)
- Oxford University Press, 2018
- 2018
- Engelska.
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Ingår i: European Heart Journal. - : Oxford University Press. - 0195-668X .- 1522-9645. ; 39, s. 902-903
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Background: Atrial fibrillation (AF) is an arrhythmia with high impact on public health. Among modifiable risk factors for the disease the role of alcohol consumption (AC) has remained inconsistent.Purpose: To assess the association between AC and incident AF across European cohorts.Methods: To study the association between self-reported AC and incident AF in N=107,845 community-based individuals from the BiomarCaRE consortium, 106,915 individuals free of AF at baseline were followed up for AF and stroke after AF. We assessed AC using validated questionnaires. Biomarkers N-terminal pro B-type natriuretic peptide (Nt-proBNP) and high sensitivity troponin I (hsTnI) were measured.Results: The median age of individuals was 47.8 years, 48.3% were men. The median of right-winsorized AC was 3 g/day. N=6,055 individuals developed AF (median follow-up time: 13.9 years). In a linear multivariable-adjusted Cox regression analyses, AC was linearly and positively associated with incident AF (Figure), hazard ratio (HR) per g/day 1.009, 95% confidence interval (CI) 1.007- 1.012, P<0.001. For one drink (12g) per day the HR was 1.15, CI 1.12–1.18, P<0.001. There was a high heterogeneity in associations across cohorts.No significant interactions of the association by Nt-proBNP and hsTnI were observed. AC was positively related to stroke risk after diagnosis of AF (HR 1.18, 95% CI 1.04–1.34, P=0.012).Conclusions: In contrast to other cardiovascular diseases, we did not observe a U-shaped association of alcohol with incident AF in the community, but a rather linearly increasing relation.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
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Csengeri, D.
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Spruenker, N. A.
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Di Castelnuovo, ...
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Niiranen, T.
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Söderberg, Stefa ...
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Magnussen, C.
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visa fler...
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Lochen, M. J.
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Kee, F.
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Blankenberg, S.
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Jørgensen, T.
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Kuulasmaa, K.
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Zeller, T.
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Salomaa, V.
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Iacoviello, L.
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Schnabel, R.
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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European Heart J ...
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Umeå universitet