Search: WFRF:(Hoffman Heather J.) >
Breast cancer risk ...
Breast cancer risk prediction in women aged 35-50 years : impact of including sex hormone concentrations in the Gail model
-
Clendenen, Tess V. (author)
-
Ge, Wenzhen (author)
-
Koenig, Karen L. (author)
-
show more...
-
Afanasyeva, Yelena (author)
-
Agnoli, Claudia (author)
-
Brinton, Louise A. (author)
-
Darvishian, Farbod (author)
-
Dorgan, Joanne F. (author)
-
Eliassen, A. Heather (author)
-
Falk, Roni T. (author)
-
- Hallmans, Göran, 1947- (author)
- Umeå universitet,Enheten för biobanksforskning,Avdelningen för hållbar hälsa
-
Hankinson, Susan E. (author)
-
Hoffman-Bolton, Judith (author)
-
Key, Timothy J. (author)
-
Krogh, Vittorio (author)
-
Nichols, Hazel B. (author)
-
Sandler, Dale P. (author)
-
Schoemaker, Minouk J. (author)
-
Sluss, Patrick M. (author)
-
- Sund, Malin (author)
- Umeå universitet,Kirurgi
-
Swerdlow, Anthony J. (author)
-
Visvanathan, Kala (author)
-
Zeleniuch-Jacquotte, Anne (author)
-
Liu, Mengling (author)
-
show less...
-
(creator_code:org_t)
- 2019-03-19
- 2019
- English.
-
In: Breast Cancer Research. - : BioMed Central. - 1465-5411 .- 1465-542X. ; 21
- Related links:
-
https://doi.org/10.1...
-
show more...
-
https://breast-cance...
-
https://umu.diva-por... (primary) (Raw object)
-
https://breast-cance...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Background: Models that accurately predict risk of breast cancer are needed to help younger women make decisions about when to begin screening. Premenopausal concentrations of circulating anti-Mullerian hormone (AMH), a biomarker of ovarian reserve, and testosterone have been positively associated with breast cancer risk in prospective studies. We assessed whether adding AMH and/or testosterone to the Gail model improves its prediction performance for women aged 35-50.Methods: In a nested case-control study including ten prospective cohorts (1762 invasive cases/1890 matched controls) with pre-diagnostic serum/plasma samples, we estimated relative risks (RR) for the biomarkers and Gail risk factors using conditional logistic regression and random-effects meta-analysis. Absolute risk models were developed using these RR estimates, attributable risk fractions calculated using the distributions of the risk factors in the cases from the consortium, and population-based incidence and mortality rates. The area under the receiver operating characteristic curve (AUC) was used to compare the discriminatory accuracy of the models with and without biomarkers.Results: The AUC for invasive breast cancer including only the Gail risk factor variables was 55.3 (95% CI 53.4, 57.1). The AUC increased moderately with the addition of AMH (AUC 57.6, 95% CI 55.7, 59.5), testosterone (AUC 56.2, 95% CI 54.4, 58.1), or both (AUC 58.1, 95% CI 56.2, 59.9). The largest AUC improvement (4.0) was among women without a family history of breast cancer.Conclusions: AMH and testosterone moderately increase the discriminatory accuracy of the Gail model among women aged 35-50. We observed the largest AUC increase for women without a family history of breast cancer, the group that would benefit most from improved risk prediction because early screening is already recommended for women with a family history.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Breast cancer risk prediction
- Anti-Mullerian hormone
- Testosterone
- Gail model
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Clendenen, Tess ...
-
Ge, Wenzhen
-
Koenig, Karen L.
-
Afanasyeva, Yele ...
-
Agnoli, Claudia
-
Brinton, Louise ...
-
show more...
-
Darvishian, Farb ...
-
Dorgan, Joanne F ...
-
Eliassen, A. Hea ...
-
Falk, Roni T.
-
Hallmans, Göran, ...
-
Hankinson, Susan ...
-
Hoffman-Bolton, ...
-
Key, Timothy J.
-
Krogh, Vittorio
-
Nichols, Hazel B ...
-
Sandler, Dale P.
-
Schoemaker, Mino ...
-
Sluss, Patrick M ...
-
Sund, Malin
-
Swerdlow, Anthon ...
-
Visvanathan, Kal ...
-
Zeleniuch-Jacquo ...
-
Liu, Mengling
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cancer and Oncol ...
- Articles in the publication
-
Breast Cancer Re ...
- By the university
-
Umeå University