Osteoprotegerin and osteocalcin are associated with atherosclerosis in patients with rheumatoid arthritis: a prospective cohort study

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Wahlin, BengtUmeå universitet,Reumatologi (author)

Osteoprotegerin and osteocalcin are associated with atherosclerosis in patients with rheumatoid arthritis : a prospective cohort study

Article/chapterEnglish2021

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2021
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LIBRIS-ID:oai:DiVA.org:umu-158061
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-158061URI

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Language:English
Summary in:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

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Previously included in thesis in manuscript form.
OBJECTIVES:Patients with rheumatoid arthritis (RA) have an accelerated progression of atherosclerosis. The aim of this study was to examine the associations between subclinical atherosclerosis, assessed by intima-media thickness (IMT), and regulators of bone formation, markers of bone turnover and bone mineral density (BMD) in patients with RA.METHODS:Patients with new-onset RA (n=79), aged ≤60 years at diagnosis, were consecutively included in a study of development of atherosclerosis. Ultrasound measurement of IMT of the common carotid artery was undertaken at inclusion (T0) and after 11 years (T11) (n=54). Bone turnover biomarkers were examined in samples collected at T0 and T11. BMD was assessed at T11.RESULTS:In patients with RA, osteocalcin (OCN) and osteoprotegerin (OPG) measured at T11 were significantly associated with IMT at T11, adjusted for systolic blood pressure (SBP) and age. BMD at T11 and the bone turnover markers procollagen type 1 N-terminal propeptide (P1NP) and carboxy-terminal crosslinked C-terminal telopeptide (CTX) were not associated with IMT. OPG, OCN and sclerostin at T0 were significantly associated with IMT at T11, and OPG and OCN at T0 were associated with change in IMT from T0 to T11. The associations between IMT and bone biomarkers were stronger in patients with joint erosions at onset of RA, than in patients with non-erosive disease.CONCLUSIONS:Atherosclerosis in patients with RA is associated with OPG and OCN, but not with BMD or markers reflecting ongoing bone turnover, indicating that atherosclerosis is not associated with bone turnover per se.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Reumatologi och inflammation hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Rheumatology and Autoimmunity hsv//eng
rheumatoid arthritis
atherosclerosis
osteoporosis
bone remodelling

Added entries (persons, corporate bodies, meetings, titles ...)

Ramnemark, AnnaUmeå universitet,Geriatrik(Swepub:umu)anra0067 (author)
Rantapää-Dahlqvist, SolbrittUmeå universitet,Reumatologi(Swepub:umu)sora0001 (author)
Wållberg-Jonsson, Solveig,1953-Umeå universitet,Reumatologi(Swepub:umu)sowa0001 (author)
Södergren, Anna,1977-Umeå universitet,Reumatologi,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM)(Swepub:umu)anayxt97 (author)
Umeå universitetReumatologi (creator_code:org_t)

Related titles

In:Clinical and Experimental Rheumatology39:6, s. 1402-14090392-856X1593-098X

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https://www.clinexprheumatol.org/abstract.asp?a=16340URL (Publiser's full text)
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-158061

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Rheumatology and ...

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