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Transcriptome-Wide Association Study Identifies New Candidate Susceptibility Genes for Glioma
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Atkins, Isabelle (author)
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Kinnersley, Ben (author)
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Ostrom, Quinn T. (author)
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Labreche, Karim (author)
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Il'yasova, Dora (author)
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Armstrong, Georgina N. (author)
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Eckel-Passow, Jeanette E. (author)
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Schoemaker, Minouk J. (author)
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Nothen, Markus M. (author)
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Barnholtz-Sloan, Jill S. (author)
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Swerdlow, Anthony J. (author)
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Simon, Matthias (author)
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Rajaraman, Preetha (author)
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Chanock, Stephen J. (author)
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Shildkraut, Joellen (author)
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Bernstein, Jonine L. (author)
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Hoffman, Per (author)
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Jockel, Karl-Heinz (author)
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Lai, Rose K. (author)
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Claus, Elizabeth B. (author)
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Olson, Sara H. (author)
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Johansen, Christoffer (author)
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Wrensch, Margaret R. (author)
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- Melin, Beatrice S. (author)
- Umeå universitet,Onkologi
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Jenkins, Robert B. (author)
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Sanson, Marc (author)
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Bondy, Melissa L. (author)
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Houlston, Richard S. (author)
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(creator_code:org_t)
- American Association for Cancer Research, 2019
- 2019
- English.
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In: Cancer Research. - : American Association for Cancer Research. - 0008-5472 .- 1538-7445. ; 79:8, s. 2065-2071
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Genome-wide association studies (GWAS) have so far identified 25 loci associated with glioma risk, with most showing specificity for either glioblastoma (GBM) or non-GBM tumors. The majority of these GWAS susceptibility variants reside in noncoding regions and the causal genes underlying the associations are largely unknown. Here we performed a transcriptome-wide association study to search for novel risk loci and candidate causal genes at known GWAS loci using Genotype-Tissue Expression Project (GTEx) data to predict cis-predicted gene expression in relation to GBM and non-GBM risk in conjunction with GWAS summary statistics on 12,488 glioma cases (6,183 GBM and 5,820 non-GBM) and 18,169 controls. Imposing a Bonferroni-corrected significance level of P < 5.69 x 10(-6), candidate novel risk locus for GBM (mean Z = 4.43; P = 5.68 x 10(-6)). GALNT6 resides at least 55 Mb away from any previously identified glioma risk variant, while all other 30 significantly associated genes were located within 1 Mb of known GWAS-identified loci and were not significant after conditioning on the known GWAS-identified variants. These data identify a novel locus (GALNT6 at 12q13.33) and 30 genes at 12 known glioma risk loci associated with glioma risk, providing further insights into glioma tumorigenesis.Significance: This study identifies new genes associated with glioma risk, increasing understanding of how these tumors develop.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Atkins, Isabelle
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Kinnersley, Ben
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Ostrom, Quinn T.
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Labreche, Karim
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Il'yasova, Dora
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Armstrong, Georg ...
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show more...
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Eckel-Passow, Je ...
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Schoemaker, Mino ...
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Nothen, Markus M ...
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Barnholtz-Sloan, ...
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Swerdlow, Anthon ...
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Simon, Matthias
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Rajaraman, Preet ...
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Chanock, Stephen ...
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Shildkraut, Joel ...
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Bernstein, Jonin ...
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Hoffman, Per
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Jockel, Karl-Hei ...
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Lai, Rose K.
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Claus, Elizabeth ...
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Olson, Sara H.
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Johansen, Christ ...
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Wrensch, Margare ...
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Melin, Beatrice ...
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Jenkins, Robert ...
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Sanson, Marc
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Bondy, Melissa L ...
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Houlston, Richar ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Cancer Research
- By the university
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Umeå University