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Search: WFRF:(Courtney M. J.) > (2015-2019) > Association of Plas...

Association of Plasma Vitamin D Metabolites With Incident Type 2 Diabetes : EPIC-InterAct Case-Cohort Study

Zheng, Ju-Sheng (author)
University of Cambridge
Imamura, Fumiaki (author)
University of Cambridge
Sharp, Stephen J. (author)
University of Cambridge
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van der Schouw, Yvonne T. (author)
Utrecht University,University Medical Center Utrecht
Sluijs, Ivonne (author)
University Medical Center Utrecht,Utrecht University
Gundersen, Thomas E. (author)
Vitas AS
Ardanaz, Eva (author)
Navarre Public Health Institute (ISPN),CIBER Epidemiology and Public Health (CIBERESP),Health Research Institute of Navarra (IDISNA)
Boeing, Heiner (author)
German Institute of Human Nutrition
Bonet, Catalina (author)
Bellvitge Biomedical Research Institute
Humberto Gomez, Jesus (author)
Murcia Regional Health Council
Dow, Courtney (author)
University of Paris-Saclay
Fagherazzi, Guy (author)
University of Paris-Saclay
Franks, Paul W. (author)
Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups
Jenab, Mazda (author)
International Agency for Research on Cancer, World Health Organization
Kuehn, Tilman (author)
German Cancer Research Centre
Kaaks, Rudolf (author)
German Cancer Research Centre
Key, Timothy J. (author)
University of Oxford
Khaw, Kay-Tee (author)
University of Cambridge
Lasheras, Cristina (author)
University of Oviedo
Mokoroa, Olatz (author)
CIBER Epidemiology and Public Health (CIBERESP),Biodonostia Health Research Institute
Mancini, Francesca Romana (author)
University of Paris-Saclay
Nilsson, Peter M. (author)
Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups
Overvad, Kim (author)
Aarhus University
Panico, Salvatore (author)
University of Naples Federico II
Palli, Domenico (author)
Institute for Cancer Research, Prevention and Clinical Network (ISPRO)
Rolandsson, Olov (author)
Umeå University,Umeå universitet,Allmänmedicin
Sieri, Sabina (author)
Istituto Nazionale dei Tumori,University of Cambridge
Salamanca-Fernandez, Elena (author)
Hospital Clínico Universitario San Cecilio,Andalusian School Of Public Health (EASP),CIBER Epidemiology and Public Health (CIBERESP),University of Granada
Sacerdote, Carlotta (author)
University of Turin,Centre for Cancer Epidemiology and Prevention (CPO Piemonte)
Spijkerman, Annemieke M. W. (author)
National Institute for Public Health and the Environment (RIVM)
Stepien, Magdalena (author)
International Agency for Research on Cancer, World Health Organization
Tjonneland, Anne (author)
Danish Cancer Society
Tumino, Rosario (author)
Civic and M.P Arezzo Hospital
Butterworth, Adam S. (author)
Riboli, Elio (author)
Imperial College London
Danesh, John (author)
Wellcome Trust Sanger Institute,Addenbrooke's Hospital,University of Cambridge
Langenberg, Claudia (author)
University of Cambridge
Forouhi, Nita G. (author)
University of Cambridge
Wareham, Nicholas J. (author)
University of Cambridge
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 (creator_code:org_t)
2018-11-09
2019
English.
In: Journal of Clinical Endocrinology and Metabolism. - : Oxford University Press. - 0021-972X .- 1945-7197. ; 104:4, s. 1293-1303
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Background: Existing evidence for the prospective association of vitamin D status with type 2 diabetes (T2D) is focused almost exclusively on circulating total 25-hydroxyvitamin D [25(OH)D] without distinction between its subtypes: nonepimeric and epimeric 25(OH)D3 stereoisomers, and 25(OH)D2, the minor component of 25(OH)D. We aimed to investigate the prospective associations of circulating levels of the sum and each of these three metabolites with incident T2D.Methods: This analysis in the European Prospective Investigation into Cancer and Nutrition (EPIC)–InterAct case-cohort study for T2D included 9671 incident T2D cases and 13,562 subcohort members. Plasma vitamin D metabolites were quantified by liquid chromatography–mass spectrometry. We used a multivariable Prentice-weighted Cox regression to estimate hazard ratios (HRs) of T2D for each metabolite. Analyses were performed separately within country, and estimates were combined across countries using random-effects meta-analysis.Results: The mean concentrations (SD) of total 25(OH)D, nonepimeric 25(OH)D3, epimeric 25(OH)D3, and 25(OH)D2 were 41.1 (17.2), 40.7 (17.3), 2.13 (1.31), and 8.16 (6.52) nmol/L, respectively. Plasma total 25(OH)D and nonepimeric 25(OH)D3 were inversely associated with incident T2D [multivariable-adjusted HR per 1 SD = 0.81 (95% CI, 0.77, 0.86) for both variables], whereas epimeric 25(OH)D3 was positively associated [per 1 SD HR = 1.16 (1.09, 1.25)]. There was no statistically significant association with T2D for 25(OH)D2 [per 1 SD HR = 0.94 (0.76, 1.18)].Conclusions: Plasma nonepimeric 25(OH)D3 was inversely associated with incident T2D, consistent with it being the major metabolite contributing to total 25(OH)D. The positive association of the epimeric form of 25(OH)D3 with incident T2D provides novel information to assess the biological relevance of vitamin D epimerization and vitamin D subtypes in diabetes etiology.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Näringslära (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Nutrition and Dietetics (hsv//eng)

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