id:"swepub:oai:DiVA.org:umu-16155"
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- Giordanetto, Fabrizio (author)
Discovery of cyclopentane- and cyclohexane-trans-1,3-diamines as potent melanin-concentrating hormone receptor 1 antagonists
- Article/chapterEnglish2007
Publisher, publication year, extent ...
- Elsevier BV,2007
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- LIBRIS-ID:oai:DiVA.org:umu-16155
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-16155URI
- https://doi.org/10.1016/j.bmcl.2007.05.034DOI
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- Language:English
- Summary in:English
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Notes
- We herein report the optimization of cyclopentane- and cyclohexane-1,3-diamine derivatives as novel and potent MCH-R1 antagonists. Structural modifications of the 2-amino-quinoline and thiophene moieties found in the initial lead compound served to improve its metabolic stability profile and MCH-R1 affinity, and revealed unprecedented SAR when compared to other 2-amino-quinoline-containing MCH-R1 antagonists.
Subject headings and genre
- Melanin-concentrating hormone receptor; MCH
- MCH-R1 antagonists
- Obesity
Added entries (persons, corporate bodies, meetings, titles ...)
- Karlsson, Olle (author)
- Lindberg, Jan (author)
- Larsson, Lars-Olof (author)
- Linusson, AnnaUmeå universitet,Kemiska institutionen(Swepub:umu)analin99 (author)
- Evertsson, Emma (author)
- Morgan, David GA (author)
- Inghardt, Tord (author)
- Umeå universitetKemiska institutionen (creator_code:org_t)
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- In:Bioorganic & Medicinal Chemistry Letters: Elsevier BV17:15, s. 4232-410960-894X
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