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Sökning: id:"swepub:oai:DiVA.org:umu-161732" > Alcohol and DNA Met...

  • Wilson, Lauren E. (författare)

Alcohol and DNA Methylation : An Epigenome-Wide Association Study in Blood and Normal Breast Tissue

  • Artikel/kapitelEngelska2019

Förlag, utgivningsår, omfång ...

  • 2019-02-14
  • Oxford University Press,2019
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-161732
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-161732URI
  • https://doi.org/10.1093/aje/kwz032DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • The biological mechanisms driving associations between alcohol consumption and chronic diseases might include epigenetic modification of DNA methylation. We explored the hypothesis that alcohol consumption is associated with methylation in an epigenome-wide association study of blood and normal breast tissue DNA. Infinium HumanMethylation450 BeadChip (Illumina Inc., San Diego, California) array data on blood DNA methylation was examined in a discovery set of 2,878 non-Hispanic white women from the Sister Study (United States, 2004-2015) who provided detailed questionnaire information on lifetime alcohol use. Robust linear regression modeling was used to identify significant associations (false discovery rate of Q < 0.05) between the number of alcoholic drinks per week and DNA methylation at 5,458 cytosine-phosphate-guanine (CpG) sites. Associations were replicated (P < 0.05) for 677 CpGs in an independent set of 187 blood DNA samples from the Sister Study and for 628 CpGs in an independent set of 171 normal breast DNA samples; 1,207 CpGs were replicated in either blood or normal breast, with 98 CpGs replicated in both tissues. Individual gene effects were notable for phosphoglycerate dehydrogenase (PGHDH), peptidyl-prolyl cis-trans isomerase (PPIF), solute carrier 15 (SLC15), solute carrier family 43 member 1 (SLC43A1), and solute carrier family 7 member 11 (SLC7A11). We also found that high alcohol consumption was associated with significantly lower global methylation as measured by the average of CpGs on the entire array.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Xu, Zongli (författare)
  • Harlid, Sophia,1978-Umeå universitet,Onkologi(Swepub:umu)soha0105 (författare)
  • White, Alexandra J. (författare)
  • Troester, Melissa A. (författare)
  • Sandler, Dale P. (författare)
  • Taylor, Jack A. (författare)
  • Umeå universitetOnkologi (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:American Journal of Epidemiology: Oxford University Press188:6, s. 1055-10650002-92621476-6256

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