Search: ((WFRF:(Kamatani Yoichiro)) pers:(Harris Tamara B.) pers:(Polasek Ozren)) >
Multiancestry Genom...
-
de Vries, Paul S.University of Texas
(author)
Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions
- Article/chapterEnglish2019
Publisher, publication year, extent ...
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2019-01-29
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Oxford University Press,2019
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-161740
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-161740URI
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https://doi.org/10.1093/aje/kwz005DOI
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https://lup.lub.lu.se/record/214a185e-d344-42e1-8185-4c5840429109URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:141294981URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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A person's lipid profile is influenced by genetic variants and alcohol consumption, but the contribution of interactions between these exposures has not been studied. We therefore incorporated gene-alcohol interactions into a multiancestry genome-wide association study of levels of high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglycerides. We included 45 studies in stage 1 (genome-wide discovery) and 66 studies in stage 2 (focused follow-up), for a total of 394,584 individuals from 5 ancestry groups. Analyses covered the period July 2014-November 2017. Genetic main effects and interaction effects were jointly assessed by means of a 2-degrees-of-freedom (df) test, and a 1-df test was used to assess the interaction effects alone. Variants at 495 loci were at least suggestively associated (P < 1 x 10(-6)) with lipid levels in stage 1 and were evaluated in stage 2, followed by combined analyses of stage 1 and stage 2. In the combined analysis of stages 1 and 2, a total of 147 independent loci were associated with lipid levels at P < 5 x 10(-8) using 2-df tests, of which 18 were novel. No genome-wide-significant associations were found testing the interaction effect alone. The novel loci included several genes (proprotein convertase subtilisin/kexin type 5 (PCSK5), vascular endothelial growth factor B (VEGFB), and apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 (APOBEC1) complementation factor (A1CF)) that have a putative role in lipid metabolism on the basis of existing evidence from cellular and experimental models.
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Brown, Michael R.
(author)
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Bentley, Amy R.
(author)
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Sung, Yun J.
(author)
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Winkler, Thomas W.
(author)
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Ntalla, Ioanna
(author)
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Schwander, Karen
(author)
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Kraja, Aldi T.
(author)
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Guo, Xiuqing
(author)
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Franceschini, Nora
(author)
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Cheng, Ching-Yu
(author)
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Sim, Xueling
(author)
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Vojinovic, Dina
(author)
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Huffman, Jennifer E.
(author)
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Musani, Solomon K.
(author)
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Li, Changwei
(author)
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Feitosa, Mary F.
(author)
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Richard, Melissa A.
(author)
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Noordam, Raymond
(author)
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Aschard, Hugues
(author)
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Bartz, Traci M.
(author)
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Bielak, Lawrence F.
(author)
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Deng, Xuan
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Dorajoo, Rajkumar
(author)
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Lohman, Kurt K.
(author)
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Manning, Alisa K.
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Rankinen, Tuomo
(author)
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Smith, Albert V.
(author)
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Tajuddin, Salman M.
(author)
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Evangelou, EvangelosKarolinska Institutet
(author)
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Graff, Mariaelisa
(author)
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Alver, Maris
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Boissel, Mathilde
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Chai, Jin Fang
(author)
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Chen, XuKarolinska Institutet
(author)
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Divers, Jasmin
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Gandin, Ilaria
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Gao, Chuan
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Goel, Anuj
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Hagemeijer, Yanick
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Harris, Sarah E.
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Hartwig, Fernando P.
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He, Meian
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Horimoto, Andrea R. V. R.
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Hsu, Fang-Chi
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Jackson, Anne U.
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Kasturiratne, Anuradhani
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Komulainen, Pirjo
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Kuehnel, Brigitte
(author)
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Laguzzi, FedericaKarolinska Institutet
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Lee, Joseph H.
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Luan, Jian'an
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Lyytikainen, Leo-Pekka
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Matoba, Nana
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Nolte, Ilja M.
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Pietzner, Maik
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Riaz, Muhammad
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Said, M. Abdullah
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Scott, Robert A.
(author)
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Sofer, Tamar
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Stancakova, Alena
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Takeuchi, Fumihiko
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Tayo, Bamidele O.
(author)
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van der Most, Peter J.
(author)
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V. Varga, TiborLund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-tv_
(author)
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Wang, Yajuan
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Ware, Erin B.
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Wen, Wanqing
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Yanek, Lisa R.
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Zhang, Weihua
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Zhao, Jing Hua
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Afaq, Saima
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Amin, Najaf
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Amini, Marzyeh
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Arking, Dan E.
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Aung, Tin
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Ballantyne, Christie
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Boerwinkle, Eric
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Broeckel, Ulrich
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Campbell, Archie
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Canouil, Mickael
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Charumathi, Sabanayagam
(author)
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Chen, Yii-Der Ida
(author)
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Connell, John M.
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de Faire, UlfKarolinska Institutet
(author)
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de las Fuentes, Lisa
(author)
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de Mutsert, Renee
(author)
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de Silva, H. Janaka
(author)
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Ding, Jingzhong
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Dominiczak, Anna F.
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Duan, Qing
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Eaton, Charles B.
(author)
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Eppinga, Ruben N.
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Faul, Jessica D.
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Fisher, Virginia
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Forrester, Terrence
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Franco, Oscar H.
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Friedlander, Yechiel
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Ghanbari, Mohsen
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Giulianini, Franco
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Grabe, Hans J.
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Grove, Megan L.
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Gu, C. Charles
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Harris, Tamara B.
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Heikkinen, Sami
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Heng, Chew-Kiat
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Hirata, Makoto
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Hixson, James E.
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Howard, Barbara V.
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Ikram, M. Arfan
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Jacobs, David R., Jr.
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Johnson, Craig
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Jonas, Jost Bruno
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Kammerer, Candace M.
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Katsuya, Tomohiro
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Khor, Chiea Chuen
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Kilpelainen, Tuomas O.
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Koh, Woon-Puay
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Koistinen, Heikki A.
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Kolcic, Ivana
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Kooperberg, Charles
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Krieger, Jose E.
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Kritchevsky, Steve B.
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Kubo, Michiaki
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Kuusisto, Johanna
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Lakka, Timo A.
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Langefeld, Carl D.
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Langenberg, Claudia
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Launer, Lenore J.
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Lehne, Benjamin
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Lemaitre, Rozenn N.
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Li, Yize
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Louie, Tin
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Magi, Reedik
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Manichaikul, Ani W.
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McKenzie, Colin A.
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Meitinger, Thomas
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Metspalu, Andres
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Milaneschi, Yuri
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Milani, Lili
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Mohlke, Karen L.Karolinska Institutet
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Mosley, Thomas H., Jr.
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Mukamal, Kenneth J.
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Nalls, Mike A.
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Nauck, Matthias
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Nelson, Christopher P.
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Sotoodehnia, Nona
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O'Connell, Jeff R.
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Palmer, Nicholette D.
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Pazoki, Raha
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Pedersen, Nancy L.Karolinska Institutet
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Peters, Annette
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Peyser, Patricia A.
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Polasek, Ozren
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Poulter, Neil
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Raffel, Leslie J.
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Raitakari, Olli T.
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Reiner, Alex P.
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Rice, Treva K.
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Rich, Stephen S.
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Robino, Antonietta
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Robinson, Jennifer G.
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Rose, Lynda M.
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Rudan, Igor
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Schmidt, Carsten O.
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Schreiner, Pamela J.
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Scott, William R.
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Sever, Peter
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Shi, Yuan
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Sidney, Stephen
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Sims, Mario
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Smith, Blair H.
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Smith, Jennifer A.
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Snieder, Harold
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Starr, John M.
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Strauch, Konstantin
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Tan, Nicholas
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Taylor, Kent D.
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Teo, Yik Ying
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Tham, Yih Chung
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Uitterlinden, Andre G.
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van Heemst, Diana
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Vuckovic, Dragana
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Waldenberger, Melanie
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Wang, Lihua
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Wang, Yujie
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Wang, Zhe
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Wei, Wen Bin
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Williams, Christine
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Wilson, Gregory, Sr.
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Wojczynski, Mary K.
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Yao, Jie
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Yu, Bing
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Yu, Caizheng
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Yuan, Jian-Min
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Zonderman, Alan B.
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Becker, Diane M.
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Boehnke, Michael
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Bowden, Donald W.
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Chambers, John C.
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Deary, Ian J.
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Esko, Tonu
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Farrall, Martin
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Franks, Paul W.Umeå University,Lund University,Lunds universitet,Umeå universitet,Avdelningen för medicin,Department of Nutrition, T. H. Chan School of Public Health, Harvard University, Boston, Massachusetts; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Skåne University Hospital, Malmö, Sweden; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, Medical Sciences Division, University of Oxford, Oxford, United Kingdom,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups(Swepub:lu)med-plf
(author)
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Freedman, Barry I.
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Froguel, Philippe
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Gasparini, Paolo
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Gieger, Christian
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Horta, Bernardo L.
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Kamatani, Yoichiro
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Kato, Norihiro
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Kooner, Jaspal S.
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Laakso, Markku
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Leander, Karin
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Lehtimaki, Terho
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Magnusson, Patrik K. E.
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Penninx, Brenda
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Pereira, Alexandre C.
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Rauramaa, Rainer
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Samani, Nilesh J.
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Scott, James
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Shu, Xiao-Ou
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van der Harst, Pim
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Wagenknecht, Lynne E.
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Wang, Ya Xing
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Wareham, Nicholas J.
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Watkins, Hugh
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Weir, David R.
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Wickremasinghe, Ananda R.
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Zheng, Wei
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Elliott, Paul
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North, Kari E.
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Bouchard, Claude
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Evans, Michele K.
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Gudnason, Vilmundur
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Liu, Ching-Ti
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Liu, Yongmei
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Psaty, Bruce M.
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Ridker, Paul M.
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van Dam, Rob M.
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Kardia, Sharon L. R.
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Fox, Ervin R.
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Hayward, Caroline
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van Duijn, Cornelia M.
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Liu, Jingmin
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Rotter, Jerome I.
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Gauderman, W. James
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Province, Michael A.
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Munroe, Patricia B.
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Rice, Kenneth
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Chasman, Daniel I.
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Cupples, L. Adrienne
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Rao, Dabeeru C.
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Morrison, Alanna C.University of Texas
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Karolinska InstitutetUniversity of Texas
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et al.
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In:American Journal of Epidemiology: Oxford University Press188:6, s. 1033-10540002-92621476-6256
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Mook-Kanamori, D ...
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Fornage, Myriam
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Kelly, Tanika N.
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Fox, Ervin R.
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Hayward, Carolin ...
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van Duijn, Corne ...
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Tai, E. Shyong
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Wong, Tien Yin
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Liu, Jingmin
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Rotter, Jerome I ...
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Gauderman, W. Ja ...
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Province, Michae ...
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Munroe, Patricia ...
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Rice, Kenneth
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Chasman, Daniel ...
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Cupples, L. Adri ...
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Rao, Dabeeru C.
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Morrison, Alanna ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Public Health Gl ...
- Articles in the publication
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American Journal ...
- By the university
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Umeå University
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Lund University
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Karolinska Institutet