Search: (WFRF:(Evangelou Evangelos)) pers:(Lehtimaki Terho) pers:(Yanek Lisa R.) >
Multiancestry Genom...
Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions
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- de Vries, Paul S. (author)
- University of Texas
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Brown, Michael R. (author)
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Bentley, Amy R. (author)
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show more...
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Sung, Yun J. (author)
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Winkler, Thomas W. (author)
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Ntalla, Ioanna (author)
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Schwander, Karen (author)
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Kraja, Aldi T. (author)
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Guo, Xiuqing (author)
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Franceschini, Nora (author)
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Cheng, Ching-Yu (author)
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Sim, Xueling (author)
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Vojinovic, Dina (author)
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Huffman, Jennifer E. (author)
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Musani, Solomon K. (author)
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Li, Changwei (author)
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Feitosa, Mary F. (author)
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Richard, Melissa A. (author)
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Noordam, Raymond (author)
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Aschard, Hugues (author)
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Bartz, Traci M. (author)
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Bielak, Lawrence F. (author)
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Deng, Xuan (author)
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Dorajoo, Rajkumar (author)
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Lohman, Kurt K. (author)
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Manning, Alisa K. (author)
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Rankinen, Tuomo (author)
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Smith, Albert V. (author)
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Tajuddin, Salman M. (author)
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- Evangelou, Evangelos (author)
- Karolinska Institutet
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Graff, Mariaelisa (author)
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Alver, Maris (author)
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Boissel, Mathilde (author)
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Chai, Jin Fang (author)
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- Chen, Xu (author)
- Karolinska Institutet
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Divers, Jasmin (author)
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Gandin, Ilaria (author)
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Gao, Chuan (author)
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Goel, Anuj (author)
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Hagemeijer, Yanick (author)
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Harris, Sarah E. (author)
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Hartwig, Fernando P. (author)
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He, Meian (author)
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Horimoto, Andrea R. V. R. (author)
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Hsu, Fang-Chi (author)
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Jackson, Anne U. (author)
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Kasturiratne, Anuradhani (author)
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Komulainen, Pirjo (author)
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Kuehnel, Brigitte (author)
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- Laguzzi, Federica (author)
- Karolinska Institutet
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Lee, Joseph H. (author)
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Luan, Jian'an (author)
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Lyytikainen, Leo-Pekka (author)
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Matoba, Nana (author)
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Nolte, Ilja M. (author)
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Pietzner, Maik (author)
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Riaz, Muhammad (author)
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Said, M. Abdullah (author)
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Scott, Robert A. (author)
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Sofer, Tamar (author)
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Stancakova, Alena (author)
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Takeuchi, Fumihiko (author)
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Tayo, Bamidele O. (author)
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van der Most, Peter J. (author)
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- V. Varga, Tibor (author)
- Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Skåne University Hospital
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Wang, Yajuan (author)
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Ware, Erin B. (author)
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Wen, Wanqing (author)
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Yanek, Lisa R. (author)
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Zhang, Weihua (author)
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Zhao, Jing Hua (author)
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Afaq, Saima (author)
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Amin, Najaf (author)
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Amini, Marzyeh (author)
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Arking, Dan E. (author)
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Aung, Tin (author)
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Ballantyne, Christie (author)
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Boerwinkle, Eric (author)
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Broeckel, Ulrich (author)
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Campbell, Archie (author)
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Canouil, Mickael (author)
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Charumathi, Sabanayagam (author)
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Chen, Yii-Der Ida (author)
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Connell, John M. (author)
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- de Faire, Ulf (author)
- Karolinska Institutet
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de las Fuentes, Lisa (author)
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de Mutsert, Renee (author)
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de Silva, H. Janaka (author)
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Ding, Jingzhong (author)
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Dominiczak, Anna F. (author)
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Duan, Qing (author)
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Eaton, Charles B. (author)
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Eppinga, Ruben N. (author)
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Faul, Jessica D. (author)
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Fisher, Virginia (author)
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Forrester, Terrence (author)
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Franco, Oscar H. (author)
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Friedlander, Yechiel (author)
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Ghanbari, Mohsen (author)
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Giulianini, Franco (author)
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Grabe, Hans J. (author)
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Grove, Megan L. (author)
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Gu, C. Charles (author)
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Harris, Tamara B. (author)
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Heikkinen, Sami (author)
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Heng, Chew-Kiat (author)
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Hirata, Makoto (author)
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Hixson, James E. (author)
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Howard, Barbara V. (author)
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Ikram, M. Arfan (author)
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Jacobs, David R., Jr. (author)
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Johnson, Craig (author)
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Jonas, Jost Bruno (author)
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Kammerer, Candace M. (author)
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Katsuya, Tomohiro (author)
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Khor, Chiea Chuen (author)
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Kilpelainen, Tuomas O. (author)
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Koh, Woon-Puay (author)
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Koistinen, Heikki A. (author)
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Kolcic, Ivana (author)
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Kooperberg, Charles (author)
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Krieger, Jose E. (author)
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Kritchevsky, Steve B. (author)
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Kubo, Michiaki (author)
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Kuusisto, Johanna (author)
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Lakka, Timo A. (author)
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Langefeld, Carl D. (author)
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Langenberg, Claudia (author)
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Launer, Lenore J. (author)
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Lehne, Benjamin (author)
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Lemaitre, Rozenn N. (author)
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Li, Yize (author)
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Liang, Jingjing (author)
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Liu, Jianjun (author)
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Liu, Kiang (author)
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Loh, Marie (author)
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Louie, Tin (author)
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Magi, Reedik (author)
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Manichaikul, Ani W. (author)
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McKenzie, Colin A. (author)
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Meitinger, Thomas (author)
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Metspalu, Andres (author)
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Milaneschi, Yuri (author)
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Milani, Lili (author)
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- Mohlke, Karen L. (author)
- Karolinska Institutet
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Mosley, Thomas H., Jr. (author)
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Mukamal, Kenneth J. (author)
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Nalls, Mike A. (author)
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Nauck, Matthias (author)
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Nelson, Christopher P. (author)
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Sotoodehnia, Nona (author)
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O'Connell, Jeff R. (author)
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Palmer, Nicholette D. (author)
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Pazoki, Raha (author)
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- Pedersen, Nancy L. (author)
- Karolinska Institutet
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Peters, Annette (author)
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Peyser, Patricia A. (author)
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Polasek, Ozren (author)
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Poulter, Neil (author)
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Raffel, Leslie J. (author)
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Raitakari, Olli T. (author)
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Reiner, Alex P. (author)
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Rice, Treva K. (author)
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Rich, Stephen S. (author)
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Robino, Antonietta (author)
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Robinson, Jennifer G. (author)
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Rose, Lynda M. (author)
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Rudan, Igor (author)
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Schmidt, Carsten O. (author)
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Schreiner, Pamela J. (author)
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Scott, William R. (author)
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Sever, Peter (author)
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Shi, Yuan (author)
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Sidney, Stephen (author)
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Sims, Mario (author)
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Smith, Blair H. (author)
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Smith, Jennifer A. (author)
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Snieder, Harold (author)
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Starr, John M. (author)
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Strauch, Konstantin (author)
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Tan, Nicholas (author)
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Taylor, Kent D. (author)
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Teo, Yik Ying (author)
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Tham, Yih Chung (author)
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Uitterlinden, Andre G. (author)
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van Heemst, Diana (author)
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Vuckovic, Dragana (author)
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Waldenberger, Melanie (author)
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Wang, Lihua (author)
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Wang, Yujie (author)
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Wang, Zhe (author)
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Wei, Wen Bin (author)
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Williams, Christine (author)
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Wilson, Gregory, Sr. (author)
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Wojczynski, Mary K. (author)
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Yao, Jie (author)
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Yu, Bing (author)
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Yu, Caizheng (author)
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Yuan, Jian-Min (author)
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Zhao, Wei (author)
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Zonderman, Alan B. (author)
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Becker, Diane M. (author)
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Boehnke, Michael (author)
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Bowden, Donald W. (author)
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Chambers, John C. (author)
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Deary, Ian J. (author)
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Esko, Tonu (author)
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Farrall, Martin (author)
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- Franks, Paul W. (author)
- Umeå University,Lund University,Lunds universitet,Umeå universitet,Avdelningen för medicin,Department of Nutrition, T. H. Chan School of Public Health, Harvard University, Boston, Massachusetts; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Skåne University Hospital, Malmö, Sweden; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, Medical Sciences Division, University of Oxford, Oxford, United Kingdom,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups
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Freedman, Barry I. (author)
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Froguel, Philippe (author)
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Gasparini, Paolo (author)
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Gieger, Christian (author)
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Horta, Bernardo L. (author)
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Kamatani, Yoichiro (author)
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Kato, Norihiro (author)
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Kooner, Jaspal S. (author)
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Laakso, Markku (author)
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Leander, Karin (author)
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Lehtimaki, Terho (author)
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Magnusson, Patrik K. E. (author)
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Penninx, Brenda (author)
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Pereira, Alexandre C. (author)
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Rauramaa, Rainer (author)
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Samani, Nilesh J. (author)
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Scott, James (author)
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Shu, Xiao-Ou (author)
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van der Harst, Pim (author)
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Wagenknecht, Lynne E. (author)
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Wang, Ya Xing (author)
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Wareham, Nicholas J. (author)
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Watkins, Hugh (author)
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Weir, David R. (author)
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Wickremasinghe, Ananda R. (author)
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Zheng, Wei (author)
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Elliott, Paul (author)
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North, Kari E. (author)
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Bouchard, Claude (author)
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Evans, Michele K. (author)
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Gudnason, Vilmundur (author)
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Liu, Ching-Ti (author)
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Liu, Yongmei (author)
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Psaty, Bruce M. (author)
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Ridker, Paul M. (author)
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van Dam, Rob M. (author)
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Kardia, Sharon L. R. (author)
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Zhu, Xiaofeng (author)
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Rotimi, Charles N. (author)
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Mook-Kanamori, Dennis O. (author)
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Fornage, Myriam (author)
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Kelly, Tanika N. (author)
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Fox, Ervin R. (author)
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Hayward, Caroline (author)
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van Duijn, Cornelia M. (author)
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Tai, E. Shyong (author)
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Wong, Tien Yin (author)
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Liu, Jingmin (author)
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Rotter, Jerome I. (author)
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Gauderman, W. James (author)
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Province, Michael A. (author)
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Munroe, Patricia B. (author)
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Rice, Kenneth (author)
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Chasman, Daniel I. (author)
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Cupples, L. Adrienne (author)
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Rao, Dabeeru C. (author)
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- Morrison, Alanna C. (author)
- University of Texas
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(creator_code:org_t)
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et al
- 2019-01-29
- 2019
- English.
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In: American Journal of Epidemiology. - : Oxford University Press. - 0002-9262 .- 1476-6256. ; 188:6, s. 1033-1054
- Related links:
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https://academic.oup...
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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http://kipublication...
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Abstract
Subject headings
Close
- A person's lipid profile is influenced by genetic variants and alcohol consumption, but the contribution of interactions between these exposures has not been studied. We therefore incorporated gene-alcohol interactions into a multiancestry genome-wide association study of levels of high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglycerides. We included 45 studies in stage 1 (genome-wide discovery) and 66 studies in stage 2 (focused follow-up), for a total of 394,584 individuals from 5 ancestry groups. Analyses covered the period July 2014-November 2017. Genetic main effects and interaction effects were jointly assessed by means of a 2-degrees-of-freedom (df) test, and a 1-df test was used to assess the interaction effects alone. Variants at 495 loci were at least suggestively associated (P < 1 x 10(-6)) with lipid levels in stage 1 and were evaluated in stage 2, followed by combined analyses of stage 1 and stage 2. In the combined analysis of stages 1 and 2, a total of 147 independent loci were associated with lipid levels at P < 5 x 10(-8) using 2-df tests, of which 18 were novel. No genome-wide-significant associations were found testing the interaction effect alone. The novel loci included several genes (proprotein convertase subtilisin/kexin type 5 (PCSK5), vascular endothelial growth factor B (VEGFB), and apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 (APOBEC1) complementation factor (A1CF)) that have a putative role in lipid metabolism on the basis of existing evidence from cellular and experimental models.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Keyword
- alcohol consumption
- cholesterol
- gene-environment interactions
- gene-lifestyle interactions
- genome-wide association studies
- lipids
- triglycerides
- alcohol consumption
- cholesterol
- gene-environment interactions
- gene-lifestyle interactions
- genome-wide association studies
- lipids
- triglycerides
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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de Vries, Paul S ...
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Brown, Michael R ...
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Bentley, Amy R.
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Sung, Yun J.
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Winkler, Thomas ...
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Ntalla, Ioanna
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show more...
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Schwander, Karen
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Kraja, Aldi T.
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Guo, Xiuqing
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Franceschini, No ...
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Cheng, Ching-Yu
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Sim, Xueling
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Vojinovic, Dina
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Huffman, Jennife ...
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Musani, Solomon ...
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Li, Changwei
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Feitosa, Mary F.
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Richard, Melissa ...
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Noordam, Raymond
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Aschard, Hugues
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Bartz, Traci M.
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Bielak, Lawrence ...
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Deng, Xuan
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Dorajoo, Rajkuma ...
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Lohman, Kurt K.
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Manning, Alisa K ...
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Rankinen, Tuomo
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Smith, Albert V.
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Tajuddin, Salman ...
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Evangelou, Evang ...
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Graff, Mariaelis ...
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Alver, Maris
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Boissel, Mathild ...
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Chai, Jin Fang
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Chen, Xu
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Divers, Jasmin
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Gandin, Ilaria
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Gao, Chuan
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Goel, Anuj
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Hagemeijer, Yani ...
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Harris, Sarah E.
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Hartwig, Fernand ...
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He, Meian
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Horimoto, Andrea ...
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Hsu, Fang-Chi
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Jackson, Anne U.
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Kasturiratne, An ...
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Komulainen, Pirj ...
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Kuehnel, Brigitt ...
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Laguzzi, Federic ...
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Lee, Joseph H.
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Luan, Jian'an
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Lyytikainen, Leo ...
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Matoba, Nana
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Nolte, Ilja M.
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Pietzner, Maik
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Riaz, Muhammad
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Said, M. Abdulla ...
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Scott, Robert A.
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Sofer, Tamar
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Stancakova, Alen ...
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Takeuchi, Fumihi ...
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Tayo, Bamidele O ...
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van der Most, Pe ...
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V. Varga, Tibor
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Wang, Yajuan
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Ware, Erin B.
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Wen, Wanqing
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Yanek, Lisa R.
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Zhang, Weihua
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Zhao, Jing Hua
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Afaq, Saima
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Amin, Najaf
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Amini, Marzyeh
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Arking, Dan E.
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Aung, Tin
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Ballantyne, Chri ...
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Boerwinkle, Eric
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Broeckel, Ulrich
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Campbell, Archie
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Canouil, Mickael
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Charumathi, Saba ...
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Chen, Yii-Der Id ...
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Connell, John M.
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de Faire, Ulf
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de las Fuentes, ...
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de Mutsert, Rene ...
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de Silva, H. Jan ...
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Ding, Jingzhong
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Dominiczak, Anna ...
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Duan, Qing
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Eaton, Charles B ...
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Eppinga, Ruben N ...
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Faul, Jessica D.
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Fisher, Virginia
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Forrester, Terre ...
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Franco, Oscar H.
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Friedlander, Yec ...
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Ghanbari, Mohsen
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Giulianini, Fran ...
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Grabe, Hans J.
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Grove, Megan L.
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Gu, C. Charles
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Harris, Tamara B ...
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Heikkinen, Sami
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Heng, Chew-Kiat
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Hirata, Makoto
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Hixson, James E.
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Howard, Barbara ...
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Ikram, M. Arfan
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Jacobs, David R. ...
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Johnson, Craig
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Jonas, Jost Brun ...
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Kammerer, Candac ...
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Katsuya, Tomohir ...
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Khor, Chiea Chue ...
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Kilpelainen, Tuo ...
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Koh, Woon-Puay
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Koistinen, Heikk ...
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Kolcic, Ivana
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Kooperberg, Char ...
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Krieger, Jose E.
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Kritchevsky, Ste ...
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Kubo, Michiaki
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Kuusisto, Johann ...
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Lakka, Timo A.
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Langefeld, Carl ...
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Langenberg, Clau ...
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Launer, Lenore J ...
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Lehne, Benjamin
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Lemaitre, Rozenn ...
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Li, Yize
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Liang, Jingjing
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Liu, Jianjun
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Liu, Kiang
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Loh, Marie
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Louie, Tin
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Magi, Reedik
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Manichaikul, Ani ...
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McKenzie, Colin ...
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Meitinger, Thoma ...
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Metspalu, Andres
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Milaneschi, Yuri
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Milani, Lili
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Mohlke, Karen L.
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Mosley, Thomas H ...
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Mukamal, Kenneth ...
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Nalls, Mike A.
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Nauck, Matthias
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Nelson, Christop ...
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Sotoodehnia, Non ...
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O'Connell, Jeff ...
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Palmer, Nicholet ...
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Pazoki, Raha
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Pedersen, Nancy ...
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Peters, Annette
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Peyser, Patricia ...
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Polasek, Ozren
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Poulter, Neil
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Raffel, Leslie J ...
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Raitakari, Olli ...
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Reiner, Alex P.
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Rice, Treva K.
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Rich, Stephen S.
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Robino, Antoniet ...
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Robinson, Jennif ...
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Rose, Lynda M.
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Rudan, Igor
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Schmidt, Carsten ...
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Schreiner, Pamel ...
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Scott, William R ...
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Sever, Peter
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Shi, Yuan
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Sidney, Stephen
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Sims, Mario
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Smith, Blair H.
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Smith, Jennifer ...
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Snieder, Harold
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Starr, John M.
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Strauch, Konstan ...
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Tan, Nicholas
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Taylor, Kent D.
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Teo, Yik Ying
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Tham, Yih Chung
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Uitterlinden, An ...
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van Heemst, Dian ...
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Vuckovic, Dragan ...
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Waldenberger, Me ...
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Wang, Lihua
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Wang, Yujie
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Wang, Zhe
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Wei, Wen Bin
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Williams, Christ ...
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Wilson, Gregory, ...
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Wojczynski, Mary ...
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Yao, Jie
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Yu, Bing
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Yu, Caizheng
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Yuan, Jian-Min
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Zhao, Wei
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Zonderman, Alan ...
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Becker, Diane M.
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Boehnke, Michael
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Bowden, Donald W ...
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Chambers, John C ...
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Deary, Ian J.
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Esko, Tonu
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Farrall, Martin
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Franks, Paul W.
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Freedman, Barry ...
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Froguel, Philipp ...
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Gasparini, Paolo
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Gieger, Christia ...
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Horta, Bernardo ...
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Kamatani, Yoichi ...
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Kato, Norihiro
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Kooner, Jaspal S ...
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Laakso, Markku
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Leander, Karin
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Lehtimaki, Terho
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Magnusson, Patri ...
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Penninx, Brenda
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Pereira, Alexand ...
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Rauramaa, Rainer
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Samani, Nilesh J ...
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Scott, James
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Shu, Xiao-Ou
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van der Harst, P ...
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Wagenknecht, Lyn ...
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Wang, Ya Xing
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Wareham, Nichola ...
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Watkins, Hugh
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Weir, David R.
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Wickremasinghe, ...
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Zheng, Wei
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Elliott, Paul
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North, Kari E.
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Bouchard, Claude
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Evans, Michele K ...
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Gudnason, Vilmun ...
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Liu, Ching-Ti
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Liu, Yongmei
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Psaty, Bruce M.
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Ridker, Paul M.
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van Dam, Rob M.
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Kardia, Sharon L ...
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Zhu, Xiaofeng
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Rotimi, Charles ...
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Mook-Kanamori, D ...
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Fornage, Myriam
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Kelly, Tanika N.
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Fox, Ervin R.
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Hayward, Carolin ...
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van Duijn, Corne ...
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Tai, E. Shyong
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Wong, Tien Yin
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Liu, Jingmin
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Rotter, Jerome I ...
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Gauderman, W. Ja ...
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Province, Michae ...
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Munroe, Patricia ...
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Rice, Kenneth
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Chasman, Daniel ...
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Cupples, L. Adri ...
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Rao, Dabeeru C.
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Morrison, Alanna ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Public Health Gl ...
- Articles in the publication
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American Journal ...
- By the university
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Umeå University
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Lund University
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Karolinska Institutet