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Staphylococcal alph...
Staphylococcal alpha-toxin tilts the balance between malignant and non-malignant CD4+ T cells in cutaneous T-cell lymphoma
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Blumel, Edda (author)
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Willerslev-Olsen, Andreas (author)
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Gluud, Maria (author)
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Lindahl, Lise M. (author)
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Fredholm, Simon (author)
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Nastasi, Claudia (author)
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Krejsgaard, Thorbjorn (author)
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Surewaard, Bas G. J. (author)
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Koralov, Sergei B. (author)
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Hu, Tengpeng (author)
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- Persson, Jenny L. (author)
- Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Clinical Research Center, Lund University, Sweden
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Bonefeld, Charlotte Menne (author)
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Geisler, Carsten (author)
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Iversen, Lars (author)
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Becker, Juergen C. (author)
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Andersen, Mads Hald (author)
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Woetmann, Anders (author)
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Buus, Terkild Brink (author)
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Odum, Niels (author)
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(creator_code:org_t)
- Taylor & Francis, 2019
- 2019
- English.
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In: Oncoimmunology. - : Taylor & Francis. - 2162-4011 .- 2162-402X. ; 8:11
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Staphylococcus aureus is implicated in disease progression in cutaneous T-cell lymphoma (CTCL). Here, we demonstrate that malignant T cell lines derived from CTCL patients as well as primary malignant CD4+ T cells from Sézary syndrome patients are considerably more resistant to alpha-toxin-induced cell death than their non-malignant counterparts. Thus, in a subset of Sézary syndrome patients the ratio between malignant and non-malignant CD4+ T cells increases significantly following exposure to alpha-toxin. Whereas toxin-induced cell death is ADAM10 dependent in healthy CD4+ T cells, resistance to alpha-toxin in malignant T cells involves both downregulation of ADAM10 as well as other resistance mechanisms. In conclusion, we provide first evidence that Staphylococcus aureus derived alpha-toxin can tilt the balance between malignant and non-malignant CD4+ T cells in CTCL patients. Consequently, alpha-toxin may promote disease progression through positive selection of malignant CD4+ T cells, identifying alpha-toxin as a putative drug target in CTCL.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Cutaneous T-cell lymphoma
- Staphylococcus aureus
- alpha-toxin
- disintegrin and metalloproteinase domain-containing protein 10
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Blumel, Edda
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Willerslev-Olsen ...
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Gluud, Maria
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Lindahl, Lise M.
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Fredholm, Simon
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Nastasi, Claudia
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show more...
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Krejsgaard, Thor ...
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Surewaard, Bas G ...
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Koralov, Sergei ...
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Hu, Tengpeng
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Persson, Jenny L ...
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Bonefeld, Charlo ...
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Geisler, Carsten
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Iversen, Lars
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Becker, Juergen ...
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Andersen, Mads H ...
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Woetmann, Anders
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Buus, Terkild Br ...
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Odum, Niels
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Oncoimmunology
- By the university
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Umeå University