Search: (WFRF:(Yu Bing)) pers:(Stevens Victoria L)
> (2020) >
Circulating markers...
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Huang, Joyce Y.University of Pittsburgh
(author)
Circulating markers of cellular immune activation in prediagnostic blood sample and lung cancer risk in the Lung Cancer Cohort Consortium (LC3)
- Article/chapterEnglish2020
Publisher, publication year, extent ...
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2019-07-22
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John Wiley & Sons,2020
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-161994
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-161994URI
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https://doi.org/10.1002/ijc.32555DOI
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https://lup.lub.lu.se/record/1b6f6a0a-4345-4478-9e60-ff678de99344URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Grant numbers United States Department of Health & Human Services, National Institutes of Health (NIH) - USA, and NIH National Cancer Institute (NCI): P01CA87969, P30CA016087, R01CA092447, R01CA144034, U01CA155340, U01CA202979, UM1CA167552, UM1CA173640, UM1CA182876, UM1CA182910, UM1CA182934, UM1CA186107Grant numbers United States Department of Health & Human Services and National Institutes of Health (NIH) - USACA047988, CA097193, CA182913, CA34944, CA40360, HL043851, HL080467, HL099355, HL26490, HL34595, P30ES000260
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Cell-mediated immune suppression may play an important role in lung carcinogenesis. We investigated the associations for circulating levels of tryptophan, kynurenine, kynurenine:tryptophan ratio (KTR), quinolinic acid (QA) and neopterin as markers of immune regulation and inflammation with lung cancer risk in 5,364 smoking-matched case-control pairs from 20 prospective cohorts included in the international Lung Cancer Cohort Consortium. All biomarkers were quantified by mass spectrometry-based methods in serum/plasma samples collected on average 6 years before lung cancer diagnosis. Odds ratios (ORs) and 95% confidence intervals (CIs) for lung cancer associated with individual biomarkers were calculated using conditional logistic regression with adjustment for circulating cotinine. Compared to the lowest quintile, the highest quintiles of kynurenine, KTR, QA and neopterin were associated with a 20-30% higher risk, and tryptophan with a 15% lower risk of lung cancer (all p(trend) < 0.05). The strongest associations were seen for current smokers, where the adjusted ORs (95% CIs) of lung cancer for the highest quintile of KTR, QA and neopterin were 1.42 (1.15-1.75), 1.42 (1.14-1.76) and 1.45 (1.13-1.86), respectively. A stronger association was also seen for KTR and QA with risk of lung squamous cell carcinoma followed by adenocarcinoma, and for lung cancer diagnosed within the first 2 years after blood draw. This study demonstrated that components of the tryptophan-kynurenine pathway with immunomodulatory effects are associated with risk of lung cancer overall, especially for current smokers. Further research is needed to evaluate the role of these biomarkers in lung carcinogenesis and progression.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Larose, Tricia L.
(author)
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Luu, Hung N.
(author)
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Wang, Renwei
(author)
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Fanidi, Anouar
(author)
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Alcala, Karine
(author)
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Stevens, Victoria L.
(author)
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Weinstein, Stephanie J.
(author)
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Albanes, Demetrius
(author)
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Caporaso, Neil E.
(author)
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Purdue, Mark P.
(author)
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Ziegler, Regina G.
(author)
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Freedman, Neal D.
(author)
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Lan, Qing
(author)
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Prentice, Ross L.
(author)
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Pettinger, Mary
(author)
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Thomson, Cynthia A.
(author)
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Cai, Qiuyin
(author)
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Wu, Jie
(author)
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Blot, William J.
(author)
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Shu, Xiao-Ou
(author)
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Zheng, Wei
(author)
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Arslan, Alan A.
(author)
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Zeleniuch-Jacquotte, Anne
(author)
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Le Marchand, Loic
(author)
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Wilkens, Lynn R.
(author)
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Haiman, Christopher A.
(author)
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Zhang, Xuehong
(author)
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Stampfer, Meir J.International Agency for Research on Cancer, World Health Organization
(author)
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Giles, Graham G.
(author)
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Hodge, Allison M.
(author)
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Severi, Gianluca
(author)
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Johansson, MikaelUmeå universitet,Onkologi,University of Pittsburgh(Swepub:umu)mijo0025
(author)
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Grankvist, KjellUmeå universitet,Klinisk kemi(Swepub:umu)kjgr0002
(author)
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Langhammer, Arnulf
(author)
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Hveem, Kristian
(author)
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Xiang, Yong-Bing
(author)
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Li, Hong-Lan
(author)
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Gao, Yu-Tang
(author)
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Visvanathan, Kala
(author)
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Ueland, Per M.
(author)
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Midttun, Oivind
(author)
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Ulvi, Arve
(author)
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Buring, Julie E.
(author)
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Lee, I-Min
(author)
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SeSS, Howard D.
(author)
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Gaziano, J. Michael
(author)
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Manjer, JonasLund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups,Skåne University Hospital(Swepub:lu)smi-jma
(author)
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Relton, Caroline
(author)
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Koh, Woon-Puay
(author)
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Brennan, Paul
(author)
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Johansson, Mattias
(author)
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Yuan, Jian-Min
(author)
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Han, Jiali
(author)
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University of PittsburghInternational Agency for Research on Cancer, World Health Organization
(creator_code:org_t)
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et al.
Related titles
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In:International Journal of Cancer: John Wiley & Sons146:9, s. 2394-24050020-71361097-0215
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- By the author/editor
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Huang, Joyce Y.
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Larose, Tricia L ...
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Luu, Hung N.
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Wang, Renwei
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Fanidi, Anouar
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Alcala, Karine
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show more...
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Stevens, Victori ...
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Weinstein, Steph ...
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Albanes, Demetri ...
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Caporaso, Neil E ...
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Purdue, Mark P.
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Ziegler, Regina ...
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Freedman, Neal D ...
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Lan, Qing
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Prentice, Ross L ...
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Pettinger, Mary
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Thomson, Cynthia ...
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Cai, Qiuyin
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Wu, Jie
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Blot, William J.
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Shu, Xiao-Ou
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Zheng, Wei
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Arslan, Alan A.
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Zeleniuch-Jacquo ...
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Le Marchand, Loi ...
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Wilkens, Lynn R.
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Haiman, Christop ...
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Zhang, Xuehong
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Stampfer, Meir J ...
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Giles, Graham G.
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Hodge, Allison M ...
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Severi, Gianluca
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Johansson, Mikae ...
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Grankvist, Kjell
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Langhammer, Arnu ...
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Hveem, Kristian
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Xiang, Yong-Bing
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Li, Hong-Lan
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Gao, Yu-Tang
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Visvanathan, Kal ...
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Ueland, Per M.
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Midttun, Oivind
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Ulvi, Arve
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Buring, Julie E.
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Lee, I-Min
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SeSS, Howard D.
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Gaziano, J. Mich ...
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Manjer, Jonas
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Relton, Caroline
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Koh, Woon-Puay
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Brennan, Paul
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Johansson, Matti ...
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Yuan, Jian-Min
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Han, Jiali
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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International Jo ...
- By the university
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Umeå University
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Lund University