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  • Neumann, J. T.Karolinska Institutet (författare)

Application of High-Sensitivity Troponin in Suspected Myocardial Infarction

  • Artikel/kapitelEngelska2019

Förlag, utgivningsår, omfång ...

  • MASSACHUSETTS MEDICAL SOC,2019
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-162346
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-162346URI
  • https://doi.org/10.1056/NEJMoa1803377DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-392882URI
  • https://lup.lub.lu.se/record/49893f33-cd7f-4c6c-8671-b69e238df378URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:141539257URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • BackgroundData regarding high-sensitivity troponin concentrations in patients presenting to the emergency department with symptoms suggestive of myocardial infarction may be useful in determining the probability of myocardial infarction and subsequent 30-day outcomes. MethodsIn 15 international cohorts of patients presenting to the emergency department with symptoms suggestive of myocardial infarction, we determined the concentrations of high-sensitivity troponin I or high-sensitivity troponin T at presentation and after early or late serial sampling. The diagnostic and prognostic performance of multiple high-sensitivity troponin cutoff combinations was assessed with the use of a derivation-validation design. A risk-assessment tool that was based on these data was developed to estimate the risk of index myocardial infarction and of subsequent myocardial infarction or death at 30 days. ResultsAmong 22,651 patients (9604 in the derivation data set and 13,047 in the validation data set), the prevalence of myocardial infarction was 15.3%. Lower high-sensitivity troponin concentrations at presentation and smaller absolute changes during serial sampling were associated with a lower likelihood of myocardial infarction and a lower short-term risk of cardiovascular events. For example, high-sensitivity troponin I concentrations of less than 6 ng per liter and an absolute change of less than 4 ng per liter after 45 to 120 minutes (early serial sampling) resulted in a negative predictive value of 99.5% for myocardial infarction, with an associated 30-day risk of subsequent myocardial infarction or death of 0.2%; a total of 56.5% of the patients would be classified as being at low risk. These findings were confirmed in an external validation data set. ConclusionsA risk-assessment tool, which we developed to integrate the high-sensitivity troponin I or troponin T concentration at emergency department presentation, its dynamic change during serial sampling, and the time between the obtaining of samples, was used to estimate the probability of myocardial infarction on emergency department presentation and 30-day outcomes.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Twerenbold, R.Univ Heart Ctr Hamburg, Hamburg, Germany;Univ Basel, Univ Hosp Basel, Cardiovasc Res Inst Basel, Basel, Switzerland;Univ Basel, Univ Hosp Basel, Dept Cardiol, Basel, Switzerland,Univ Med Ctr Hamburg Eppendorf, Inst Clin Chem & Lab Med, Hamburg, Germany (författare)
  • Ojeda, F.Univ Heart Ctr Hamburg, Hamburg, Germany (författare)
  • Soerensen, N. A.Univ Heart Ctr Hamburg, Hamburg, Germany;German Ctr Cardiovasc Res DZHK, Partner Site Hamburg Kiel Lubeck, Hamburg, Germany,Univ Edinburgh, British Heart Fdn, Ctr Cardiovasc Sci, Edinburgh, Midlothian, Scotland (författare)
  • Chapman, A. R.Univ Edinburgh, British Heart Fdn, Ctr Cardiovasc Sci, Edinburgh, Midlothian, Scotland (författare)
  • Shah, A. S. V.Univ Edinburgh, British Heart Fdn, Ctr Cardiovasc Sci, Edinburgh, Midlothian, Scotland;Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Edinburgh, Midlothian, Scotland,Natl Inst Hlth & Welf, Helsinki, Finland,Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden;Umea Univ, Heart Ctr, Cardiol, Umea, Sweden,Catalan Dept Hlth, Barcelona, Spain (författare)
  • Anand, A.Lund Univ, Skane Univ Hosp, Dept Internal & Emergency Med, Lund, Sweden,Heidelberg Univ Hosp, Dept Cardiol, Heidelberg, Germany;DZHK Partner Site Heidelberg Mannheim, Heidelberg, Germany,German Res Ctr Environm Hlth, Inst Epidemiol, Helmholtz Zentrum, Munich, Germany;DZHK Partner Site Munich Heart Alliance, Munich, Germany,McMaster Univ, Div Emergency Med, Hamilton, ON, Canada,McMaster Univ, Dept Pathol & Mol Med, Hamilton, ON, Canada,Royal Brisbane & Womens Hosp, Dept Emergency Med, Herston, Qld, Australia;Queensland Univ Technol, Inst Hlth & Biomed Innovat, Kelvin Grove, Australia (författare)
  • Boeddinghaus, J.Univ Basel, Univ Hosp Basel, Cardiovasc Res Inst Basel, Basel, Switzerland;Univ Basel, Univ Hosp Basel, Dept Cardiol, Basel, Switzerland (författare)
  • Nestelberger, T.Univ Basel, Univ Hosp Basel, Cardiovasc Res Inst Basel, Basel, Switzerland;Univ Basel, Univ Hosp Basel, Dept Cardiol, Basel, Switzerland (författare)
  • Badertscher, P.Univ Basel, Univ Hosp Basel, Cardiovasc Res Inst Basel, Basel, Switzerland;Univ Basel, Univ Hosp Basel, Dept Cardiol, Basel, Switzerland (författare)
  • Mokhtari, ArashLund University,Lunds universitet,Thoraxkirurgi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,NPWT teknologin,Forskargrupper vid Lunds universitet,Skonsammare hjärtkirurgi,Thoracic Surgery,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,NPWT technology,Lund University Research Groups,Less invasive cardiac surgery(Swepub:lu)thor-ami (författare)
  • Pickering, J. W.Univ Otago Christchurch, Dept Med, Christchurch, New Zealand;Christchurch Hosp, Emergency Dept, Christchurch, New Zealand,Johannes Gutenberg Univ Mainz, Ctr Cardiol, Prevent Cardiol & Prevent Med, Univ Med Ctr, Mainz, Germany;Johannes Gutenberg Univ Mainz, Univ Med Ctr, Ctr Thrombosis & Hemostasis, Mainz, Germany (författare)
  • Troughton, R. W.Univ Otago Christchurch, Dept Med, Christchurch, New Zealand;Christchurch Hosp, Emergency Dept, Christchurch, New Zealand (författare)
  • Greenslade, J.Royal Brisbane & Womens Hosp, Dept Emergency Med, Herston, Qld, Australia;Queensland Univ Technol, Inst Hlth & Biomed Innovat, Kelvin Grove, Australia (författare)
  • Parsonage, W.Royal Brisbane & Womens Hosp, Cardiol, Herston, Qld, Australia;Queensland Univ Technol, Inst Hlth & Biomed Innovat, Kelvin Grove, Australia (författare)
  • Mueller-Hennessen, M.Heidelberg Univ Hosp, Dept Cardiol, Heidelberg, Germany;DZHK Partner Site Heidelberg Mannheim, Heidelberg, Germany (författare)
  • Gori, T.Johannes Gutenberg Univ Mainz, Cardiol 1, Univ Med Ctr, Mainz, Germany (författare)
  • Jernberg, T. (författare)
  • Morris, N.Univ Manchester, Manchester, Lancs, England;Manchester Univ Fdn Trust, Manchester, Lancs, England (författare)
  • Liebetrau, C.Kerckhoff Heart & Thorax Ctr, DZHK Partner Site Rhine Main, Bad Nauheim, Germany;Kerckhoff Heart & Thorax Ctr, Dept Cardiol, Bad Nauheim, Germany;Justus Liebig Univ Giessen & Marburg, Dept Cardiol, Giessen, Germany (författare)
  • Hamm, C.Kerckhoff Heart & Thorax Ctr, DZHK Partner Site Rhine Main, Bad Nauheim, Germany;Kerckhoff Heart & Thorax Ctr, Dept Cardiol, Bad Nauheim, Germany;Justus Liebig Univ Giessen & Marburg, Dept Cardiol, Giessen, Germany (författare)
  • Katus, H. A. (författare)
  • Muenzel, T.Johannes Gutenberg Univ Mainz, Cardiol 1, Univ Med Ctr, Mainz, Germany,Univ Otago Christchurch, Dept Med, Christchurch, New Zealand;Christchurch Hosp, Emergency Dept, Christchurch, New Zealand (författare)
  • Landmesser, U.Charite Univ Med Berlin, Campus Benjamin Franklin, Berlin Inst Hlth, Dept Cardiol, Berlin, Germany;DZHK Partner Site Berlin, Berlin, Germany (författare)
  • Salomaa, V. (författare)
  • Iacoviello, L.Ist Ricovero & Cura Carattere Sci Neuromed, Dept Epidemiol & Prevent, Pozzilli, Italy;Univ Insubria, Res Ctr Epidemiol & Prevent Med, Dept Med & Surg, Varese, Italy (författare)
  • Ferrario, M. M.Univ Insubria, Res Ctr Epidemiol & Prevent Med, Dept Med & Surg, Varese, Italy (författare)
  • Giampaoli, S.Natl Inst Hlth, Dept Cardiovasc Dysmetabol & Aging Associated Dis, Rome, Italy (författare)
  • Kee, F.Queens Univ Belfast, Clin Res Collaborat Publ Hlth, Belfast, Antrim, North Ireland (författare)
  • Thorand, B.German Res Ctr Environm Hlth, Inst Epidemiol, Helmholtz Zentrum, Munich, Germany (författare)
  • Peters, A. (författare)
  • Borchini, R.Univ Insubria, Res Ctr Epidemiol & Prevent Med, Dept Med & Surg, Varese, Italy (författare)
  • Jorgensen, T. (författare)
  • Söderberg, StefanUmeå universitet,Kardiologi,Univ Heart Ctr Hamburg, Hamburg, Germany;German Ctr Cardiovasc Res DZHK, Partner Site Hamburg Kiel Lubeck, Hamburg, Germany(Swepub:umu)stso0001 (författare)
  • Sans, S. (författare)
  • Tunstall-Pedoe, H.Univ Dundee, Inst Cardiovasc Res, Cardiovasc Epidemiol Unit, Dundee, Scotland (författare)
  • Kuulasmaa, K.Natl Inst Hlth & Welf, Helsinki, Finland,Univ Med Ctr Mainz, Inst Clin Chem & Lab Med, Mainz, Germany (författare)
  • Renne, T. (författare)
  • Lackner, K. J. (författare)
  • Worster, A. (författare)
  • Body, R.Univ Manchester, Manchester, Lancs, England;Manchester Univ Fdn Trust, Manchester, Lancs, England (författare)
  • Ekelund, UlfLund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Experimentell kärlforskning,Forskargrupper vid Lunds universitet,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Experimental Vascular Research,Lund University Research Groups(Swepub:lu)mphy-uek (författare)
  • Kavsak, P. A. (författare)
  • Keller, T.Kerckhoff Heart & Thorax Ctr, DZHK Partner Site Rhine Main, Bad Nauheim, Germany;Kerckhoff Heart & Thorax Ctr, Dept Cardiol, Bad Nauheim, Germany,Univ Heart Ctr Hamburg, Hamburg, Germany;German Ctr Cardiovasc Res DZHK, Partner Site Hamburg Kiel Lubeck, Hamburg, Germany (författare)
  • Lindahl, Bertil,1957-Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)(Swepub:uu)belin227 (författare)
  • Wild, P. (författare)
  • Giannitsis, E.Heidelberg Univ Hosp, Dept Cardiol, Heidelberg, Germany;DZHK Partner Site Heidelberg Mannheim, Heidelberg, Germany (författare)
  • Than, M. (författare)
  • Cullen, L. A. (författare)
  • Mills, N. L.Univ Edinburgh, British Heart Fdn, Ctr Cardiovasc Sci, Edinburgh, Midlothian, Scotland;Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Edinburgh, Midlothian, Scotland (författare)
  • Mueller, C.Univ Basel, Univ Hosp Basel, Cardiovasc Res Inst Basel, Basel, Switzerland;Univ Basel, Univ Hosp Basel, Dept Cardiol, Basel, Switzerland (författare)
  • Zeller, T. (författare)
  • Westermann, D.Univ Heart Ctr Hamburg, Hamburg, Germany;German Ctr Cardiovasc Res DZHK, Partner Site Hamburg Kiel Lubeck, Hamburg, Germany (författare)
  • Blankenberg, S.German Centre for Cardiovascular Research,University Medical Center Hamburg-Eppendorf (författare)
  • Karolinska InstitutetUniv Heart Ctr Hamburg, Hamburg, Germany;Univ Basel, Univ Hosp Basel, Cardiovasc Res Inst Basel, Basel, Switzerland;Univ Basel, Univ Hosp Basel, Dept Cardiol, Basel, Switzerland (creator_code:org_t)
  • et al.

Sammanhörande titlar

  • Ingår i:New England Journal of Medicine: MASSACHUSETTS MEDICAL SOC380:26, s. 2529-25400028-47931533-4406

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