Sökning: WFRF:(Vitonis A) >
Predicting Circulat...
Predicting Circulating CA125 Levels among Healthy Premenopausal Women
-
- Sasamoto, Naoko (författare)
- Harvard University,Brigham and Women's Hospital / Harvard Medical School
-
- Babic, Ana (författare)
- Brigham and Women's Hospital / Harvard Medical School,Harvard University,Dana-Farber Cancer Institute
-
- Rosner, Bernard A. (författare)
- Harvard University,Brigham and Women's Hospital / Harvard Medical School
-
visa fler...
-
- Fortner, Renee T. (författare)
- German Cancer Research Centre
-
- Vitonis, Allison F. (författare)
- Brigham and Women's Hospital / Harvard Medical School
-
- Yamamoto, Hidemi (författare)
- Brigham and Women's Hospital / Harvard Medical School
-
- Fichorova, Raina N. (författare)
- Harvard University,Brigham and Women's Hospital / Harvard Medical School
-
- Tjonneland, Anne (författare)
- Danish Cancer Society
-
- Hansen, Louise (författare)
- Danish Cancer Society
-
- Overvad, Kim (författare)
- Aarhus University
-
- Kvaskoff, Marina (författare)
- University of Paris-Saclay
-
- Fournier, Agnes (författare)
- University of Paris-Saclay
-
- Mancini, Francesca Romana (författare)
- University of Paris-Saclay
-
- Boeing, Heiner (författare)
- German Institute of Human Nutrition
-
- Trichopoulou, Antonia (författare)
- National and Kapodistrian University of Athens,Hellenic Health Foundation, Athens
-
- Peppa, Eleni (författare)
- Hellenic Health Foundation, Athens
-
- Karakatsani, Anna (författare)
- National and Kapodistrian University of Athens,Hellenic Health Foundation, Athens
-
- Palli, Domenico (författare)
- Institute for Cancer Research, Prevention and Clinical Network (ISPRO)
-
- Pala, Valeria (författare)
- Istituto Nazionale dei Tumori
-
- Mattiello, Amalia (författare)
- University of Naples Federico II
-
- Tumino, Rosario (författare)
- Civic and M.P Arezzo Hospital
-
- Grasso, Chiara C. (författare)
- University of Turin
-
- Onland-Moret, N. Charlotte (författare)
- University Medical Center Utrecht
-
- Weiderpass, Elisabete (författare)
- Karolinska Institutet,University of Helsinki,Cancer Registry of Norway, Institute of Population-Based Cancer Research,UiT The Arctic University of Norway, Tromsø
-
- Ramon Quiros, J. (författare)
- Public Health Directorate
-
- Lujan-Barroso, Leila (författare)
- Bellvitge University Hospital-IDIBELL
-
- Rodriguez-Barranco, Miguel (författare)
- CIBER Epidemiology and Public Health (CIBERESP),Andalusian School Of Public Health (EASP)
-
- Colorado-Yohar, Sandra (författare)
- University of Antioquia,Murcia Regional Health Council
-
- Barricarte, Aurelio (författare)
- Health Research Institute of Navarra (IDISNA),CIBER Epidemiology and Public Health (CIBERESP)
-
- Dorronsoro, Miren (författare)
- CIBER Epidemiology and Public Health (CIBERESP)
-
- Idahl, Annika, 1965- (författare)
- Umeå University,Umeå universitet,Obstetrik och gynekologi,Näringsforskning
-
- Lundin, Eva (författare)
- Umeå University,Umeå universitet,Patologi
-
- Sartor, Hanna (författare)
- Lund University,Lunds universitet,Diagnostisk radiologi, Malmö,Forskargrupper vid Lunds universitet,Radiology Diagnostics, Malmö,Lund University Research Groups,Skåne University Hospital
-
- Khaw, Kay-Tee (författare)
- University of Cambridge
-
- Key, Timothy J. (författare)
- University of Oxford
-
- Muller, David (författare)
- Imperial College London
-
- Riboli, Elio (författare)
- International Agency for Research on Cancer, World Health Organization
-
- Gunter, Marc J. (författare)
- International Agency for Research on Cancer, World Health Organization
-
- Dossus, Laure (författare)
- International Agency for Research on Cancer, World Health Organization
-
- Kaaks, Rudolf (författare)
- German Cancer Research Centre
-
- Cramer, Daniel W. (författare)
- Harvard University,Brigham and Women's Hospital / Harvard Medical School
-
- Tworoger, Shelley S. (författare)
- H. Lee Moffitt Cancer Center & Research Institute
-
- Terry, Kathryn L. (författare)
- Brigham and Women's Hospital / Harvard Medical School,Harvard University
-
visa färre...
-
(creator_code:org_t)
- American Association for Cancer Research (AACR), 2019
- 2019
- Engelska.
-
Ingår i: Cancer Epidemiology, Biomarkers and Prevention. - : American Association for Cancer Research (AACR). - 1055-9965 .- 1538-7755. ; 28:6, s. 1076-1085
- Relaterad länk:
-
http://dx.doi.org/10...
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://lup.lub.lu.s...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- Background: Cancer antigen 125 (CA125) is the most promising ovarian cancer screening biomarker to date. Multiple studies reported CA125 levels vary by personal characteristics, which could inform personalized CA125 thresholds. However, this has not been well described in premenopausal women. Methods: We evaluated predictors of CA125 levels among 815 premenopausal women from the New England Case Control Study (NEC). We developed linear and dichotomous (>= 35 U/mL) CA125 prediction models and externally validated an abridged model restricting to available predictors among 473 premenopausal women in the European Prospective Investigation into Cancer and Nutrition Study (EPIC). Results: The final linear CA125 prediction model included age, race, tubal ligation, endometriosis, menstrual phase at blood draw, and fibroids, which explained 7% of the total variance of CA125. The correlation between observed and predicted CA125 levels based on the abridged model (including age, race, and menstrual phase at blood draw) had similar correlation coefficients in NEC (r = 0.22) and in EPIC (r = 0.22). The dichotomous CA125 prediction model included age, tubal ligation, endometriosis, prior personal cancer diagnosis, family history of ovarian cancer, number of miscarriages, menstrual phase at blood draw, and smoking status with AUC of 0.83. The abridged dichotomous model (including age, number of miscarriages, menstrual phase at blood draw, and smoking status) showed similar AUCs in NEC (0.73) and in EPIC (0.78). Conclusions: We identified a combination of factors associated with CA125 levels in premenopausal women. Impact: Our model could be valuable in identifying healthy women likely to have elevated CA125 and consequently improve its specificity for ovarian cancer screening.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Sasamoto, Naoko
-
Babic, Ana
-
Rosner, Bernard ...
-
Fortner, Renee T ...
-
Vitonis, Allison ...
-
Yamamoto, Hidemi
-
visa fler...
-
Fichorova, Raina ...
-
Tjonneland, Anne
-
Hansen, Louise
-
Overvad, Kim
-
Kvaskoff, Marina
-
Fournier, Agnes
-
Mancini, Frances ...
-
Boeing, Heiner
-
Trichopoulou, An ...
-
Peppa, Eleni
-
Karakatsani, Ann ...
-
Palli, Domenico
-
Pala, Valeria
-
Mattiello, Amali ...
-
Tumino, Rosario
-
Grasso, Chiara C ...
-
Onland-Moret, N. ...
-
Weiderpass, Elis ...
-
Ramon Quiros, J.
-
Lujan-Barroso, L ...
-
Rodriguez-Barran ...
-
Colorado-Yohar, ...
-
Barricarte, Aure ...
-
Dorronsoro, Mire ...
-
Idahl, Annika, 1 ...
-
Lundin, Eva
-
Sartor, Hanna
-
Khaw, Kay-Tee
-
Key, Timothy J.
-
Muller, David
-
Riboli, Elio
-
Gunter, Marc J.
-
Dossus, Laure
-
Kaaks, Rudolf
-
Cramer, Daniel W ...
-
Tworoger, Shelle ...
-
Terry, Kathryn L ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Hälsovetenskap
-
och Folkhälsovetensk ...
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Cancer och onkol ...
- Artiklar i publikationen
-
Cancer Epidemiol ...
- Av lärosätet
-
Umeå universitet
-
Lunds universitet
-
Karolinska Institutet