Search: (WFRF:(Rosenberger A)) pers:(Chen Chu) pers:(Marcus Michael W.)
> (2019) >
Elevated Platelet C...
Elevated Platelet Count Appears to Be Causally Associated with Increased Risk of Lung Cancer : A Mendelian Randomization Analysis
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- Zhu, Ying (author)
- Nanjing Medical University
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Wei, Yongyue (author)
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Zhang, Ruyang (author)
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show more...
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Dong, Xuesi (author)
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Shen, Sipeng (author)
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Zhao, Yang (author)
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Bai, Jianling (author)
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Albanes, Demetrius (author)
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Caporaso, Neil E. (author)
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Landi, Maria Teresa (author)
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Zhu, Bin (author)
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Chanock, Stephen J. (author)
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Gu, Fangyi (author)
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Lam, Stephen (author)
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Tsao, Ming-Sound (author)
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Shepherd, Frances A. (author)
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Tardon, Adonina (author)
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Fernandez-Somoano, Ana (author)
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Fernandez-Tardon, Guillermo (author)
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- Chen, Chu (author)
- Harvard University,Nanjing Medical University
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Barnett, Matthew J. (author)
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Doherty, Jennifer (author)
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Bojesen, Stig E. (author)
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Johansson, Mattias (author)
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Brennan, Paul (author)
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Mckay, James D. (author)
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Carreras-Torres, Robert (author)
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Muley, Thomas (author)
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Risch, Angela (author)
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Wichmann, Heunz-Erich (author)
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Bickeboeller, Heike (author)
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Rosenberger, Albert (author)
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Rennert, Gad (author)
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Saliba, Walid (author)
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Arnold, Susanne M. (author)
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Field, John K. (author)
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Davies, Michael P. A. (author)
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Marcus, Michael W. (author)
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Wu, Xifeng (author)
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Ye, Yuanqing (author)
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Le Marchand, Loic (author)
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Wilkens, Lynne R. (author)
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- Melander, Olle (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
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- Manjer, Jonas (author)
- Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups
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- Brunnström, Hans (author)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Förbättrad diagnostik och prognostik vid lungcancer och metastaser till lunga,Forskargrupper vid Lunds universitet,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Improved diagnostics and prognostics of lung cancer and metastases to the lungs,Lund University Research Groups
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Hung, Rayjean J. (author)
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Liu, Geoffrey (author)
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Brhane, Yonathan (author)
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Kachuri, Linda (author)
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Andrew, Angeline S. (author)
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Duell, Eric J. (author)
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Kiemeney, Lambertus A. (author)
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van der Heijden, Erik H. F. M. (author)
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Haugen, Aage (author)
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Zienolddiny, Shanbeh (author)
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Skaug, Vidar (author)
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- Grankvist, Kjell (author)
- Umeå universitet,Klinisk kemi
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- Johansson, Mikael (author)
- Umeå universitet,Onkologi
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Woll, Penella J. (author)
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Cox, Angela (author)
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Taylor, Fiona (author)
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Teare, Dawn M. (author)
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Lazarus, Philip (author)
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Schabath, Matthew B. (author)
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Aldrich, Melinda C. (author)
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Houlston, Richard S. (author)
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McLaughlin, John (author)
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Stevens, Victoria L. (author)
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Shen, Hongbing (author)
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Hu, Zhibin (author)
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Dai, Juncheng (author)
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Amos, Christopher I. (author)
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Han, Younghun (author)
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Zhu, Dakai (author)
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Goodman, Gary E. (author)
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Chen, Feng (author)
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Christiani, David C. (author)
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(creator_code:org_t)
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et al
- American Association for Cancer Research (AACR), 2019
- 2019
- English.
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In: Cancer Epidemiology, Biomarkers and Prevention. - : American Association for Cancer Research (AACR). - 1055-9965 .- 1538-7755. ; 28:5, s. 935-942
- Related links:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Subject headings
Close
- Background: Platelets are a critical element in coagulation and inflammation, and activated platelets are linked to cancer risk through diverse mechanisms. However, a causal relationship between platelets and risk of lung cancer remains unclear. Methods: We performed single and combined multiple instrumental variable Mendelian randomization analysis by an inverse-weighted method, in addition to a series of sensitivity analyses. Summary data for associations between SNPs and platelet count are from a recent publication that included 48,666 Caucasian Europeans, and the International Lung Cancer Consortium and Transdisciplinary Research in Cancer of the Lung data consisting of 29,266 cases and 56,450 controls to analyze associations between candidate SNPs and lung cancer risk. Results: Multiple instrumental variable analysis incorporating six SNPs showed a 62% increased risk of overall nonsmall cell lung cancer [NSCLC; OR, 1.62; 95% confidence interval (CI), 1.15-2.27; P = 0.005] and a 200% increased risk for small-cell lung cancer (OR, 3.00; 95% CI, 1.27-7.06; P = 0.01). Results showed only a trending association with NSCLC histologic subtypes, which may be due to insufficient sample size and/or weak effect size. A series of sensitivity analysis retained these findings. Conclusions: Our findings suggest a causal relationship between elevated platelet count and increased risk of lung cancer and provide evidence of possible antiplatelet interventions for lung cancer prevention. Impact: These findings provide a better understanding of lung cancer etiology and potential evidence for antiplatelet interventions for lung cancer prevention.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Zhu, Ying
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Wei, Yongyue
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Zhang, Ruyang
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Dong, Xuesi
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Shen, Sipeng
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Zhao, Yang
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show more...
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Bai, Jianling
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Albanes, Demetri ...
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Caporaso, Neil E ...
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Landi, Maria Ter ...
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Zhu, Bin
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Chanock, Stephen ...
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Gu, Fangyi
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Lam, Stephen
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Tsao, Ming-Sound
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Shepherd, France ...
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Tardon, Adonina
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Fernandez-Somoan ...
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Fernandez-Tardon ...
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Chen, Chu
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Barnett, Matthew ...
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Doherty, Jennife ...
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Bojesen, Stig E.
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Johansson, Matti ...
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Brennan, Paul
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Mckay, James D.
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Carreras-Torres, ...
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Muley, Thomas
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Risch, Angela
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Wichmann, Heunz- ...
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Bickeboeller, He ...
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Rosenberger, Alb ...
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Rennert, Gad
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Saliba, Walid
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Arnold, Susanne ...
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Field, John K.
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Davies, Michael ...
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Marcus, Michael ...
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Wu, Xifeng
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Ye, Yuanqing
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Le Marchand, Loi ...
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Wilkens, Lynne R ...
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Melander, Olle
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Manjer, Jonas
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Brunnström, Hans
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Hung, Rayjean J.
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Liu, Geoffrey
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Brhane, Yonathan
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Kachuri, Linda
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Andrew, Angeline ...
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Duell, Eric J.
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Kiemeney, Lamber ...
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van der Heijden, ...
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Haugen, Aage
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Zienolddiny, Sha ...
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Skaug, Vidar
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Grankvist, Kjell
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Johansson, Mikae ...
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Woll, Penella J.
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Cox, Angela
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Taylor, Fiona
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Teare, Dawn M.
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Lazarus, Philip
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Schabath, Matthe ...
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Aldrich, Melinda ...
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Houlston, Richar ...
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McLaughlin, John
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Stevens, Victori ...
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Shen, Hongbing
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Hu, Zhibin
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Dai, Juncheng
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Amos, Christophe ...
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Han, Younghun
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Zhu, Dakai
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Goodman, Gary E.
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Chen, Feng
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Christiani, Davi ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Public Health Gl ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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Cancer Epidemiol ...
- By the university
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Umeå University
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Lund University