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  • Howick, Virginia M. (author)

The Malaria Cell Atlas : Single parasite transcriptomes across the complete Plasmodium life cycle

  • Article/chapterEnglish2019

Publisher, publication year, extent ...

  • American Association for the Advancement of Science,2019
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-163672
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-163672URI
  • https://doi.org/10.1126/science.aaw2619DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Malaria parasites adopt a remarkable variety of morphological life stages as they transition through multiple mammalian host and mosquito vector environments. We profiled the single-cell transcriptomes of thousands of individual parasites, deriving the first high-resolution transcriptional atlas of the entire Plasmodium berghei life cycle. We then used our atlas to precisely define developmental stages of single cells from three different human malaria parasite species, including parasites isolated directly from infected individuals. The Malaria Cell Atlas provides both a comprehensive view of gene usage in a eukaryotic parasite and an open-access reference dataset for the study of malaria parasites.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Russell, Andrew J. C. (author)
  • Andrews, Tallulah (author)
  • Heaton, Haynes (author)
  • Reid, Adam J. (author)
  • Natarajan, Kedar (author)
  • Butungi, Hellen (author)
  • Metcalf, Tom (author)
  • Verzier, Lisa H. (author)
  • Rayner, Julian C. (author)
  • Berriman, Matthew (author)
  • Herren, Jeremy K. (author)
  • Billker, OliverUmeå universitet,Molekylär Infektionsmedicin, Sverige (MIMS),Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet),Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK(Swepub:umu)olbi0005 (author)
  • Hemberg, Martin (author)
  • Talman, Arthur M. (author)
  • Lawniczak, Mara K. N. (author)
  • Umeå universitetMolekylär Infektionsmedicin, Sverige (MIMS) (creator_code:org_t)

Related titles

  • In:Science: American Association for the Advancement of Science365:64550036-80751095-9203

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