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Insulin-like growth...
Insulin-like growth factor I in pregnancy and maternal risk of breast cancer
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- Lukanova, Annekatrin (författare)
- Umeå universitet,Näringsforskning
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Toniolo, Paolo (författare)
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Zeleniuch-Jacquotte, Anne (författare)
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- Grankvist, Kjell (författare)
- Umeå universitet,Klinisk kemi
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- Wulff, Marianne (författare)
- Umeå universitet,Obstetrik och gynekologi
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Arslan, Alan A (författare)
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Afanasyeva, Yelena (författare)
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- Johansson, Robert (författare)
- Umeå universitet,Onkologi
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- Lenner, Per (författare)
- Umeå universitet,Onkologi
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- Hallmans, Göran (författare)
- Umeå universitet,Näringsforskning
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- Wadell, Göran (författare)
- Umeå universitet,Virologi
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- Lundin, Eva (författare)
- Umeå universitet,Patologi
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(creator_code:org_t)
- Baltimore : Waverly Press, 2006
- 2006
- Engelska.
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Ingår i: Cancer Epidemiology, Biomarkers and Prevention. - Baltimore : Waverly Press. - 1055-9965 .- 1538-7755. ; 15:12, s. 2489-2493
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Background: The role of insulin-like growth factor (IGF)-I in breast cancer remains controversial, despite numerous reports on the association of the hormone with breast cancer or high-risk mammographic densities. We hypothesized that exposure to elevated IGF-I during early pregnancy, a period characterized by intense cell proliferation in the breasts and in the presence of high concentrations of sex steroids, will be associated with increased maternal risk to develop a breast malignancy. Methods: The Northern Sweden Maternity Cohort is an ongoing prospective study, collecting blood samples from first-trimester-pregnant women since 1975 as part of screening for infectious diseases. A case-control study (212 cases and 369 controls) was nested among Northern Sweden Maternity Cohort members who delivered singleton babies. RIA was used to measure IGF-I and IGF-II levels. Conditional logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (95% CI). Results: Breast cancer risk increased with increasing IGF-I (top tertile OR, 1.7; 95% CI, 1.1-2.7). The association was stronger among the primiparous (OR, 2.2; 95% CI, 1.1-4.4) than in the nonprimiparous women (OR, 1.4; 95% CI, 0.7-2.8). Upper-tertile risks seemed to decrease within the <28-, 28 to 33, and >33-year groups of age at sampling, from 2.5 (0.9-7.6) to 2.1 (0.9-5.0) and 1.2 (0.5-2.5), respectively. There was no association of breast cancer with first-trimester-pregnancy IGF-II. Conclusions: The study offers further evidence that IGF-I is important in breast cancer. Our findings suggest that the adverse effect of IGF-I on the breast may be stronger before the remodeling of the gland induced by a first pregnancy.
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Lukanova, Anneka ...
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Toniolo, Paolo
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Zeleniuch-Jacquo ...
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Grankvist, Kjell
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Wulff, Marianne
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Arslan, Alan A
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visa fler...
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Afanasyeva, Yele ...
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Johansson, Rober ...
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Lenner, Per
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Hallmans, Göran
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Wadell, Göran
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Lundin, Eva
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visa färre...
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Cancer Epidemiol ...
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Umeå universitet