Search: (WFRF:(Björk Eriksson Thomas)) pers:(Mofors J) >
Concomitant Ro/SSA ...
Concomitant Ro/SSA and La/SSB antibodies are biomarkers for the risk of venous thromboembolism and cerebral infarction in primary Sjögren's syndrome
-
- Mofors, J. (author)
- Karolinska Institutet,Karolinska Institute,Karolinska Univ Hosp, Sweden
-
- Holmqvist, M. (author)
- Karolinska Institutet
-
- Westermark, L. (author)
- Uppsala University,Uppsala universitet,Reumatologi,Uppsala Univ, Sweden
-
show more...
-
- Björk, A. (author)
- Karolinska Institutet,Karolinska Institute,Karolinska Univ Hosp, Sweden
-
- Kvarnström, M. (author)
- Karolinska Institutet,Karolinska Institute,Karolinska Univ Hosp, Sweden
-
- Forsblad-d'Elia, Helena (author)
- Umeå University,Umeå universitet,Reumatologi,Umea Univ, Dept Publ Hlth & Clin Med, Rheumatol, Umea, Sweden
-
- Bucher, S. Magnusson (author)
- Örebro University,Orebro Univ, Sweden
-
- Eriksson, Per (author)
- Linköpings universitet,Linköping University,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Reumatologiska kliniken i Östergötland
-
- Theander, Elke (author)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Lund Univ, Sweden
-
- Mandl, Thomas (author)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Lund Univ, Sweden
-
- Wahren-Herlenius, M. (author)
- Karolinska Institutet,Karolinska Institute,Karolinska Univ Hosp, Sweden
-
- Nordmark, Gunnel (author)
- Uppsala University,Uppsala universitet,Reumatologi,Uppsala Univ, Sweden
-
show less...
-
(creator_code:org_t)
- 2019-06-17
- 2019
- English.
-
In: Journal of Internal Medicine. - : John Wiley & Sons. - 0954-6820 .- 1365-2796. ; 286:4, s. 458-468
- Related links:
-
https://doi.org/10.1...
-
show more...
-
https://umu.diva-por... (primary) (Raw object)
-
https://onlinelibrar...
-
http://dx.doi.org/10... (free)
-
https://liu.diva-por... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
https://lup.lub.lu.s...
-
https://urn.kb.se/re...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- Background: To assess the risk of incident cardiovascular disease in patients with primary Sjögren's syndrome, overall and stratified by Ro/SSA and La/SSB autoantibody status.Methods: A cohort of patients with primary Sjögren's syndrome in Sweden (n = 960) and matched controls from the general population (n = 9035) were included, and data extracted from the National Patient Register to identify events of myocardial infarction, cerebral infarction and venous thromboembolism. Hazard ratios were estimated using cox proportional hazard regressions.Results: During a median follow‐up of 9.5 years, the overall hazard ratio (HR) was 1.6 (95% CI 1.2–2.1) for myocardial infarction, 1.2 (95% CI 0.9–1.7) for cerebral infarction and 2.1 (95% CI 1.6–2.9) for venous thromboembolism. Patients positive for both Ro/SSA and La/SSB autoantibodies had a substantially higher risk of cerebral infarction (HR 1.7, 95% CI 1.0–2.9) and venous thromboembolism (HR 3.1, 95% CI 1.9–4.8) than the general population. These risks were not significantly increased in Ro/SSA‐ and La/SSB‐negative patients. Among autoantibody‐positive patients, the highest HR of cerebral infarction was seen after ≥10 years disease duration (HR 2.8, 95% CI 1.4–5.4), while the HR for venous thromboembolism was highest 0–5 years after disease diagnosis (HR 4.7, 95% CI 2.3–9.3) and remained high throughout disease duration.Conclusions: Primary Sjögren's syndrome is associated with a markedly increased risk of cardiovascular disease and the presence of Ro/SSA and La/SSB autoantibodies identify the subgroup of patients carrying the highest risk. These findings suggest that monitoring and prevention of cardiovascular disease in this patient group should be considered.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Keyword
- autoantibodies
- cardiovascular disease
- La
- SSB
- Primary Sjögren's syndrome
- Ro
- SSA
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Mofors, J.
-
Holmqvist, M.
-
Westermark, L.
-
Björk, A.
-
Kvarnström, M.
-
Forsblad-d'Elia, ...
-
show more...
-
Bucher, S. Magnu ...
-
Eriksson, Per
-
Theander, Elke
-
Mandl, Thomas
-
Wahren-Herlenius ...
-
Nordmark, Gunnel
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cardiac and Card ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Rheumatology and ...
- Articles in the publication
-
Journal of Inter ...
- By the university
-
Umeå University
-
Uppsala University
-
Lund University
-
Linköping University
-
Karolinska Institutet