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Concomitant Ro/SSA ...
Concomitant Ro/SSA and La/SSB antibodies are biomarkers for the risk of venous thromboembolism and cerebral infarction in primary Sjögren's syndrome
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- Mofors, J. (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska Univ Hosp, Sweden
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- Holmqvist, M. (författare)
- Karolinska Institutet
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- Westermark, L. (författare)
- Uppsala University,Uppsala universitet,Reumatologi,Uppsala Univ, Sweden
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- Björk, A. (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska Univ Hosp, Sweden
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- Kvarnström, M. (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska Univ Hosp, Sweden
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- Forsblad-d'Elia, Helena (författare)
- Umeå University,Umeå universitet,Reumatologi,Umea Univ, Dept Publ Hlth & Clin Med, Rheumatol, Umea, Sweden
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- Bucher, S. Magnusson (författare)
- Örebro University,Orebro Univ, Sweden
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- Eriksson, Per (författare)
- Linköpings universitet,Linköping University,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Reumatologiska kliniken i Östergötland
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- Theander, Elke (författare)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Lund Univ, Sweden
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- Mandl, Thomas (författare)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Lund Univ, Sweden
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- Wahren-Herlenius, M. (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska Univ Hosp, Sweden
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- Nordmark, Gunnel (författare)
- Uppsala University,Uppsala universitet,Reumatologi,Uppsala Univ, Sweden
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(creator_code:org_t)
- 2019-06-17
- 2019
- Engelska.
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Ingår i: Journal of Internal Medicine. - : John Wiley & Sons. - 0954-6820 .- 1365-2796. ; 286:4, s. 458-468
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://lup.lub.lu.s...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background: To assess the risk of incident cardiovascular disease in patients with primary Sjögren's syndrome, overall and stratified by Ro/SSA and La/SSB autoantibody status.Methods: A cohort of patients with primary Sjögren's syndrome in Sweden (n = 960) and matched controls from the general population (n = 9035) were included, and data extracted from the National Patient Register to identify events of myocardial infarction, cerebral infarction and venous thromboembolism. Hazard ratios were estimated using cox proportional hazard regressions.Results: During a median follow‐up of 9.5 years, the overall hazard ratio (HR) was 1.6 (95% CI 1.2–2.1) for myocardial infarction, 1.2 (95% CI 0.9–1.7) for cerebral infarction and 2.1 (95% CI 1.6–2.9) for venous thromboembolism. Patients positive for both Ro/SSA and La/SSB autoantibodies had a substantially higher risk of cerebral infarction (HR 1.7, 95% CI 1.0–2.9) and venous thromboembolism (HR 3.1, 95% CI 1.9–4.8) than the general population. These risks were not significantly increased in Ro/SSA‐ and La/SSB‐negative patients. Among autoantibody‐positive patients, the highest HR of cerebral infarction was seen after ≥10 years disease duration (HR 2.8, 95% CI 1.4–5.4), while the HR for venous thromboembolism was highest 0–5 years after disease diagnosis (HR 4.7, 95% CI 2.3–9.3) and remained high throughout disease duration.Conclusions: Primary Sjögren's syndrome is associated with a markedly increased risk of cardiovascular disease and the presence of Ro/SSA and La/SSB autoantibodies identify the subgroup of patients carrying the highest risk. These findings suggest that monitoring and prevention of cardiovascular disease in this patient group should be considered.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Nyckelord
- autoantibodies
- cardiovascular disease
- La
- SSB
- Primary Sjögren's syndrome
- Ro
- SSA
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Mofors, J.
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Holmqvist, M.
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Westermark, L.
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Björk, A.
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Kvarnström, M.
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Forsblad-d'Elia, ...
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visa fler...
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Bucher, S. Magnu ...
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Eriksson, Per
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Theander, Elke
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Mandl, Thomas
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Wahren-Herlenius ...
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Nordmark, Gunnel
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Reumatologi och ...
- Artiklar i publikationen
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Journal of Inter ...
- Av lärosätet
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Umeå universitet
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Uppsala universitet
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Lunds universitet
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Linköpings universitet
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Karolinska Institutet