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Interplay between t...
Interplay between the Mediterranean diet and C-reactive protein genetic polymorphisms towards inflammation in adolescents
- Article/chapterEnglish2020
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Churchill Livingstone,2020
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LIBRIS-ID:oai:DiVA.org:umu-164179
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-164179URI
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https://doi.org/10.1016/j.clnu.2019.08.016DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:143793800URI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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AIM: From a nutrigenetics perspective, we aim to investigate the moderating role of the Mediterranean diet and each of its subgroups in the association between C-reactive protein (CRP) gene polymorphisms and CRP blood concentration in adolescents.METHODS: In 562 adolescents (13-17 y) of the European HELENA study, data was available on circulating CRP levels as inflammatory biomarker, three CRP gene SNPs (rs3093068, rs1204, rs1130864), food intake determined by a self-administered computerized 24 h-dietary recall for 2 days, and body composition. A 9-point Mediterranean diet score and each food subgroup were tested as moderator via SNP*diet interaction. Analyzes were adjusted for age, sex, puberty, adiposity and socioeconomic status.RESULTS: The minor allele frequencies of rs3093068 and rs1130864 SNPs (GG and TT, respectively) were associated with higher CRP concentrations, while rs1205 (CT/TT) was associated with lower CRP concentrations. There were significant interactions between rs3093068 and Mediterranean diet (B = -0.1139, p = 0.011), or the fish food subgroup (B = -0.0090, p = 0.022), so that those with the highest genetic CRP risk underwent the highest CRP attenuation by a healthier diet. Although the effect of diet and SNP was substantial, the explained variance by interaction was only 1%.CONCLUSION: Greater adherence to the Mediterranean diet and particularly its fish component was associated with a lower CRP blood concentrations especially in those at highest genetic risk due to the rs3093068 SNP.
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Meirhaeghe, Aline
(author)
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Dallongeville, Jean
(author)
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Moreno, Luis A
(author)
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Lourenço, Gustavo Jacob
(author)
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Marcos, Ascensión
(author)
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Huybrechts, Inge
(author)
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Manios, Yannis
(author)
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Lambrinou, Christina-Paulina
(author)
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Gottrand, Frederic
(author)
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Kafatos, Anthony
(author)
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Kersting, Mathilde
(author)
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Sjöström, MichaelKarolinska Institutet
(author)
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Widhalm, Kurt
(author)
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Ferrari, Marika
(author)
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Molnár, Denes
(author)
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González-Gross, Marcela
(author)
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Forsner, Maria,1954-Karolinska Institutet,Umeå universitet,Institutionen för omvårdnad(Swepub:umu)maafor73
(author)
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De Henauw, Stefaan
(author)
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Michels, Nathalie
(author)
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Karolinska InstitutetInstitutionen för omvårdnad
(creator_code:org_t)
Related titles
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In:Clinical Nutrition: Churchill Livingstone39:6, s. 1919-19260261-56141532-1983
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Arouca, Aline B
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Meirhaeghe, Alin ...
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Dallongeville, J ...
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Moreno, Luis A
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Lourenço, Gustav ...
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Marcos, Ascensió ...
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Huybrechts, Inge
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Manios, Yannis
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Lambrinou, Chris ...
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Gottrand, Freder ...
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Kafatos, Anthony
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Kersting, Mathil ...
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Sjöström, Michae ...
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Widhalm, Kurt
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Ferrari, Marika
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Molnár, Denes
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González-Gross, ...
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Forsner, Maria, ...
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De Henauw, Stefa ...
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Michels, Nathali ...
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MEDICAL AND HEAL ...
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Clinical Nutriti ...
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Umeå University
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Karolinska Institutet