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Interplay between t...
Interplay between the Mediterranean diet and C-reactive protein genetic polymorphisms towards inflammation in adolescents
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Arouca, Aline B (författare)
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Meirhaeghe, Aline (författare)
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Dallongeville, Jean (författare)
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Moreno, Luis A (författare)
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Lourenço, Gustavo Jacob (författare)
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Marcos, Ascensión (författare)
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Huybrechts, Inge (författare)
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Manios, Yannis (författare)
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Lambrinou, Christina-Paulina (författare)
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Gottrand, Frederic (författare)
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Kafatos, Anthony (författare)
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Kersting, Mathilde (författare)
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- Sjöström, Michael (författare)
- Karolinska Institutet
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Widhalm, Kurt (författare)
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Ferrari, Marika (författare)
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Molnár, Denes (författare)
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González-Gross, Marcela (författare)
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- Forsner, Maria, 1954- (författare)
- Karolinska Institutet,Umeå universitet,Institutionen för omvårdnad
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De Henauw, Stefaan (författare)
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Michels, Nathalie (författare)
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(creator_code:org_t)
- Churchill Livingstone, 2020
- 2020
- Engelska.
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Ingår i: Clinical Nutrition. - : Churchill Livingstone. - 0261-5614 .- 1532-1983. ; 39:6, s. 1919-1926
- Relaterad länk:
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https://digital.csic...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- AIM: From a nutrigenetics perspective, we aim to investigate the moderating role of the Mediterranean diet and each of its subgroups in the association between C-reactive protein (CRP) gene polymorphisms and CRP blood concentration in adolescents.METHODS: In 562 adolescents (13-17 y) of the European HELENA study, data was available on circulating CRP levels as inflammatory biomarker, three CRP gene SNPs (rs3093068, rs1204, rs1130864), food intake determined by a self-administered computerized 24 h-dietary recall for 2 days, and body composition. A 9-point Mediterranean diet score and each food subgroup were tested as moderator via SNP*diet interaction. Analyzes were adjusted for age, sex, puberty, adiposity and socioeconomic status.RESULTS: The minor allele frequencies of rs3093068 and rs1130864 SNPs (GG and TT, respectively) were associated with higher CRP concentrations, while rs1205 (CT/TT) was associated with lower CRP concentrations. There were significant interactions between rs3093068 and Mediterranean diet (B = -0.1139, p = 0.011), or the fish food subgroup (B = -0.0090, p = 0.022), so that those with the highest genetic CRP risk underwent the highest CRP attenuation by a healthier diet. Although the effect of diet and SNP was substantial, the explained variance by interaction was only 1%.CONCLUSION: Greater adherence to the Mediterranean diet and particularly its fish component was associated with a lower CRP blood concentrations especially in those at highest genetic risk due to the rs3093068 SNP.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Omvårdnad (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nursing (hsv//eng)
Nyckelord
- C-reactive protein
- Inflammation
- Interaction
- Mediterranean diet
- Nutrigenomics
- Single nucleotide polymorphism
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Arouca, Aline B
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Meirhaeghe, Alin ...
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Dallongeville, J ...
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Moreno, Luis A
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Lourenço, Gustav ...
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Marcos, Ascensió ...
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visa fler...
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Huybrechts, Inge
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Manios, Yannis
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Lambrinou, Chris ...
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Gottrand, Freder ...
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Kafatos, Anthony
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Kersting, Mathil ...
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Sjöström, Michae ...
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Widhalm, Kurt
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Ferrari, Marika
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Molnár, Denes
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González-Gross, ...
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Forsner, Maria, ...
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De Henauw, Stefa ...
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Michels, Nathali ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Omvårdnad
- Artiklar i publikationen
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Clinical Nutriti ...
- Av lärosätet
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Umeå universitet
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Karolinska Institutet