Search: (WFRF:(Forsner Maria 1954 ))
> (2020-2023) >
Interplay between t...
Interplay between the Mediterranean diet and C-reactive protein genetic polymorphisms towards inflammation in adolescents
-
Arouca, Aline B (author)
-
Meirhaeghe, Aline (author)
-
Dallongeville, Jean (author)
-
show more...
-
Moreno, Luis A (author)
-
Lourenço, Gustavo Jacob (author)
-
Marcos, Ascensión (author)
-
Huybrechts, Inge (author)
-
Manios, Yannis (author)
-
Lambrinou, Christina-Paulina (author)
-
Gottrand, Frederic (author)
-
Kafatos, Anthony (author)
-
Kersting, Mathilde (author)
-
- Sjöström, Michael (author)
- Karolinska Institutet
-
Widhalm, Kurt (author)
-
Ferrari, Marika (author)
-
Molnár, Denes (author)
-
González-Gross, Marcela (author)
-
- Forsner, Maria, 1954- (author)
- Karolinska Institutet,Umeå universitet,Institutionen för omvårdnad
-
De Henauw, Stefaan (author)
-
Michels, Nathalie (author)
-
show less...
-
(creator_code:org_t)
- Churchill Livingstone, 2020
- 2020
- English.
-
In: Clinical Nutrition. - : Churchill Livingstone. - 0261-5614 .- 1532-1983. ; 39:6, s. 1919-1926
- Related links:
-
https://digital.csic...
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- AIM: From a nutrigenetics perspective, we aim to investigate the moderating role of the Mediterranean diet and each of its subgroups in the association between C-reactive protein (CRP) gene polymorphisms and CRP blood concentration in adolescents.METHODS: In 562 adolescents (13-17 y) of the European HELENA study, data was available on circulating CRP levels as inflammatory biomarker, three CRP gene SNPs (rs3093068, rs1204, rs1130864), food intake determined by a self-administered computerized 24 h-dietary recall for 2 days, and body composition. A 9-point Mediterranean diet score and each food subgroup were tested as moderator via SNP*diet interaction. Analyzes were adjusted for age, sex, puberty, adiposity and socioeconomic status.RESULTS: The minor allele frequencies of rs3093068 and rs1130864 SNPs (GG and TT, respectively) were associated with higher CRP concentrations, while rs1205 (CT/TT) was associated with lower CRP concentrations. There were significant interactions between rs3093068 and Mediterranean diet (B = -0.1139, p = 0.011), or the fish food subgroup (B = -0.0090, p = 0.022), so that those with the highest genetic CRP risk underwent the highest CRP attenuation by a healthier diet. Although the effect of diet and SNP was substantial, the explained variance by interaction was only 1%.CONCLUSION: Greater adherence to the Mediterranean diet and particularly its fish component was associated with a lower CRP blood concentrations especially in those at highest genetic risk due to the rs3093068 SNP.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Omvårdnad (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nursing (hsv//eng)
Keyword
- C-reactive protein
- Inflammation
- Interaction
- Mediterranean diet
- Nutrigenomics
- Single nucleotide polymorphism
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Arouca, Aline B
-
Meirhaeghe, Alin ...
-
Dallongeville, J ...
-
Moreno, Luis A
-
Lourenço, Gustav ...
-
Marcos, Ascensió ...
-
show more...
-
Huybrechts, Inge
-
Manios, Yannis
-
Lambrinou, Chris ...
-
Gottrand, Freder ...
-
Kafatos, Anthony
-
Kersting, Mathil ...
-
Sjöström, Michae ...
-
Widhalm, Kurt
-
Ferrari, Marika
-
Molnár, Denes
-
González-Gross, ...
-
Forsner, Maria, ...
-
De Henauw, Stefa ...
-
Michels, Nathali ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Health Sciences
-
and Nursing
- Articles in the publication
-
Clinical Nutriti ...
- By the university
-
Umeå University
-
Karolinska Institutet