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Peritoneal infectio...
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Grahn, OskarUmeå universitet,Institutionen för diagnostik och intervention,Kirurgi
(författare)
Peritoneal infection after colorectal cancer surgery induces substantial alterations in postoperative protein levels : an exploratory study
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Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:umu-223591
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-223591URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:vet swepub-contenttype
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Ämneskategori:ovr swepub-publicationtype
Anmärkningar
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Purpose: Peritoneal infection, due to anastomotic leakage, after resection for colorectal cancer have been shown to associate with increased cancer recurrence and mortality, as well as cardiovascsular morbidity. Alterations in circulating protein levels could help shed light on the underlying mechanisms, prompting this exploratory study of 64 patients operated for colorectal cancer with anastomosis.Methods: Thirty-two cases who suffered a postoperative peritoneal infection were matched with 32 controls who had a complication-free postoperative stay. Proteins in serum samples at their first postoperative visit and at one year after surgery were analysed using proximity extension assays and enzyme-linked immunosorbent assays. Multivariate projection methods, adjusted for multiple testing, were used to compare levels between groups, and enrichment and network analyses were performed.Results: Seventy-seven proteins, out of 270 tested, were differentially expressed at a median sampling time of 41 days after surgery. Many of the differentially expressed top hub proteins have known involvement in cancer progression, survival, invasiveness and metastasis. Over-represented pathways were related to cardiomyopathy, cell-adhesion, extracellular matrix, phosphatidylinositol-3-kinase/Akt (PI3K/Akt) and transforming growth factor beta (TGF-β) signaling.Conclusion: These affected proteins and pathways could provide clues as to why these patients might suffer increased cancer recurrence, mortality and cardiovascular morbidity.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Holmgren, KlasUmeå universitet,Institutionen för diagnostik och intervention,Kirurgi(Swepub:umu)klho0002
(författare)
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Jonsson, PärUmeå universitet,Kemiska institutionen(Swepub:umu)parjon95
(författare)
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Borgmästars, EmmyUmeå universitet,Institutionen för diagnostik och intervention,Kirurgi(Swepub:umu)embo0061
(författare)
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Lundin, Christina,1970-Umeå universitet,Institutionen för diagnostik och intervention,Kirurgi(Swepub:umu)chlu0008
(författare)
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Sund, MalinUmeå universitet,Institutionen för diagnostik och intervention,Kirurgi,Department of Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland(Swepub:umu)masu0021
(författare)
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Rutegård, Martin,1982-Umeå universitet,Institutionen för diagnostik och intervention,Kirurgi,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM)(Swepub:umu)maru0039
(författare)
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Umeå universitetInstitutionen för diagnostik och intervention
(creator_code:org_t)
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