Search: (WFRF:(Selby Peter J)) pers:(Selby A) >
IL-17-high asthma w...
IL-17-high asthma with features of a psoriasis immunophenotype
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Östling, Jörgen (author)
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van Geest, Marleen (author)
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Schofield, James P. R. (author)
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show more...
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Jevnikar, Zala (author)
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Wilson, Susan (author)
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Ward, Jonathan (author)
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Lutter, Rene (author)
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Shaw, Dominick E. (author)
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Bakke, Per S. (author)
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Caruso, Massimo (author)
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- Dahlen, Sven-Erik (author)
- Karolinska Institutet
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Fowler, Stephen J. (author)
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Horvath, Ildiko (author)
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Krug, Norbert (author)
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Montuschi, Paolo (author)
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Sanak, Marek (author)
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- Sandström, Thomas, 1957- (author)
- Umeå universitet,Avdelningen för medicin
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Sun, Kai (author)
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Pandis, Ioannis (author)
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Auffray, Charles (author)
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Sousa, Ana R. (author)
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Guo, Yike (author)
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Adcock, Ian M. (author)
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Howarth, Peter (author)
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Chung, Kian Fan (author)
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Bigler, Jeanette (author)
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Sterk, Peter J. (author)
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Skipp, Paul J. (author)
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Djukanovic, Ratko (author)
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Vaarala, Outi (author)
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Ahmed, H. (author)
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Auffray, C. (author)
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Bakke, P. (author)
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Bansal, A. T. (author)
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Baribaud, F. (author)
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Bates, S. (author)
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Bel, E. H. (author)
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Bigler, J. (author)
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Bisgaard, H. (author)
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Boedigheimer, M. J. (author)
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Bonnelykke, K. (author)
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Brandsma, J. (author)
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Brinkman, P. (author)
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Bucchioni, E. (author)
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Burg, D. (author)
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Bush, A. (author)
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Caruso, M. (author)
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Chaiboonchoe, A. (author)
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Chanez, P. (author)
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Chung, K. F. (author)
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Compton, C. H. (author)
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Corfield, J. (author)
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D'Amico, A. (author)
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Dahlen, S. E. (author)
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De Meulder, B. (author)
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Djukanovic, R. (author)
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Erpenbeck, V. J. (author)
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Erzen, D. (author)
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Fichtner, K. (author)
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Fitch, N. (author)
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Fleming, L. J. (author)
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Formaggio, E. (author)
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Fowler, S. J. (author)
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Frey, U. (author)
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Gahlemann, M. (author)
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Geiser, T. (author)
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Guo, Y. (author)
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Hashimoto, S. (author)
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Haughney, J. (author)
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- Hedlin, G. (author)
- Karolinska Institutet
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Hekking, P. W. (author)
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Higenbottam, T. (author)
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Hohlfeld, J. M. (author)
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Holweg, C. (author)
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Horvath, I. (author)
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Howarth, P. (author)
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- James, A. J. (author)
- Karolinska Institutet
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Knowles, R. (author)
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Knox, A. J. (author)
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Krug, N. (author)
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Lefaudeux, D. (author)
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Loza, M. J. (author)
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Lutter, R. (author)
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Manta, A. (author)
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Masefield, S. (author)
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Matthews, J. G. (author)
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Mazein, A. (author)
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Meiser, A. (author)
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- Middelveld, R. J. M. (author)
- Karolinska Institutet
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Miralpeix, M. (author)
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Montuschi, P. (author)
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Mores, N. (author)
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Murray, C. S. (author)
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Musial, J. (author)
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Myles, D. (author)
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Pahus, L. (author)
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Pandis, I. (author)
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Pavlidis, S. (author)
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Powell, P. (author)
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Pratico, G. (author)
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Valls, M. Puig (author)
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Rao, N. (author)
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Riley, J. (author)
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Roberts, A. (author)
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Roberts, G. (author)
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Rowe, A. (author)
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Sandström, T. (author)
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Seibold, W. (author)
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Selby, A. (author)
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Shaw, D. E. (author)
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Sigmund, R. (author)
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Singer, F. (author)
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Skipp, P. J. (author)
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Sousa, A. R. (author)
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Sterk, P. J. (author)
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Sun, K. (author)
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Thornton, B. (author)
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van Aalderen, W. M. (author)
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van Geest, M. (author)
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Vestbo, J. (author)
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Vissing, N. H. (author)
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Wagener, A. H. (author)
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Wagers, S. S. (author)
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Weiszhart, Z. (author)
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- Wheelock, C. E. (author)
- Karolinska Institutet
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Wilson, S. J. (author)
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(creator_code:org_t)
- Elsevier, 2019
- 2019
- English.
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In: Journal of Allergy and Clinical Immunology. - : Elsevier. - 0091-6749 .- 1097-6825. ; 144:5, s. 1198-1213
- Related links:
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http://www.jacionlin...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Subject headings
Close
- Background: The role of IL-17 immunity is well established in patients with inflammatory diseases, such as psoriasis and inflammatory bowel disease, but not in asthmatic patients, in whom further study is required.Objective: We sought to undertake a deep phenotyping study of asthmatic patients with upregulated IL-17 immunity.Methods: Whole-genome transcriptomic analysis was performed by using epithelial brushings, bronchial biopsy specimens (91 asthmatic patients and 46 healthy control subjects), and whole blood samples (n = 498) from the Unbiased Biomarkers for the Prediction of Respiratory Disease Outcomes (U-BIOPRED) cohort. Gene signatures induced in vitro by IL-17 and IL-13 in bronchial epithelial cells were used to identify patients with IL-17–high and IL-13–high asthma phenotypes.Results: Twenty-two of 91 patients were identified with IL-17, and 9 patients were identified with IL-13 gene signatures. The patients with IL-17–high asthma were characterized by risk of frequent exacerbations, airway (sputum and mucosal) neutrophilia, decreased lung microbiota diversity, and urinary biomarker evidence of activation of the thromboxane B2 pathway. In pathway analysis the differentially expressed genes in patients with IL-17-high asthma were shared with those reported as altered in psoriasis lesions and included genes regulating epithelial barrier function and defense mechanisms, such as IL1B, IL6, IL8, and β-defensin.Conclusion: The IL-17–high asthma phenotype, characterized by bronchial epithelial dysfunction and upregulated antimicrobial and inflammatory response, resembles the immunophenotype of psoriasis, including activation of the thromboxane B2 pathway, which should be considered a biomarker for this phenotype in further studies, including clinical trials targeting IL-17.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Keyword
- IL-17
- asthma
- bronchial biopsies
- bronchial brushings
- biomarkers
- psoriasis
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Östling, Jörgen
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van Geest, Marle ...
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Schofield, James ...
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Jevnikar, Zala
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Wilson, Susan
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Ward, Jonathan
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show more...
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Lutter, Rene
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Shaw, Dominick E ...
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Bakke, Per S.
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Caruso, Massimo
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Dahlen, Sven-Eri ...
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Fowler, Stephen ...
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Horvath, Ildiko
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Krug, Norbert
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Montuschi, Paolo
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Sanak, Marek
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Sandström, Thoma ...
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Sun, Kai
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Pandis, Ioannis
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Auffray, Charles
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Sousa, Ana R.
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Guo, Yike
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Adcock, Ian M.
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Howarth, Peter
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Chung, Kian Fan
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Bigler, Jeanette
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Sterk, Peter J.
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Skipp, Paul J.
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Djukanovic, Ratk ...
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Vaarala, Outi
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Ahmed, H.
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Auffray, C.
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Bakke, P.
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Bansal, A. T.
-
Baribaud, F.
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Bates, S.
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Bel, E. H.
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Bigler, J.
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Bisgaard, H.
-
Boedigheimer, M. ...
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Bonnelykke, K.
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Brandsma, J.
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Brinkman, P.
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Bucchioni, E.
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Burg, D.
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Bush, A.
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Caruso, M.
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Chaiboonchoe, A.
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Chanez, P.
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Chung, K. F.
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Compton, C. H.
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Corfield, J.
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D'Amico, A.
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Dahlen, S. E.
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De Meulder, B.
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Djukanovic, R.
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Erpenbeck, V. J.
-
Erzen, D.
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Fichtner, K.
-
Fitch, N.
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Fleming, L. J.
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Formaggio, E.
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Fowler, S. J.
-
Frey, U.
-
Gahlemann, M.
-
Geiser, T.
-
Guo, Y.
-
Hashimoto, S.
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Haughney, J.
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Hedlin, G.
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Hekking, P. W.
-
Higenbottam, T.
-
Hohlfeld, J. M.
-
Holweg, C.
-
Horvath, I.
-
Howarth, P.
-
James, A. J.
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Knowles, R.
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Knox, A. J.
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Krug, N.
-
Lefaudeux, D.
-
Loza, M. J.
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Lutter, R.
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Manta, A.
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Masefield, S.
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Matthews, J. G.
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Mazein, A.
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Meiser, A.
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Middelveld, R. J ...
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Miralpeix, M.
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Montuschi, P.
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Mores, N.
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Murray, C. S.
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Musial, J.
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Myles, D.
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Pahus, L.
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Pandis, I.
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Pavlidis, S.
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Powell, P.
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Pratico, G.
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Valls, M. Puig
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Rao, N.
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Riley, J.
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Roberts, A.
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Roberts, G.
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Rowe, A.
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Sandström, T.
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Seibold, W.
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Selby, A.
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Shaw, D. E.
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Sigmund, R.
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Singer, F.
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Skipp, P. J.
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Sousa, A. R.
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Sterk, P. J.
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Sun, K.
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Thornton, B.
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van Aalderen, W. ...
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van Geest, M.
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Vestbo, J.
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Vissing, N. H.
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Wagener, A. H.
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Wagers, S. S.
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Weiszhart, Z.
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Wheelock, C. E.
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Wilson, S. J.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Respiratory Medi ...
- Articles in the publication
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Journal of Aller ...
- By the university
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Umeå University
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Karolinska Institutet