SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Alm Johan PhD)
 

Sökning: WFRF:(Alm Johan PhD) > (2019) > Antibodies against ...

  • Boman, AntoniaUmeå universitet,Reumatologi,Umea Univ, Dept Publ Hlth & Clin Med Rheumatol, Umea, Sweden (författare)

Antibodies against citrullinated peptides are associated with clinical and radiological outcomes in patients with early rheumatoid arthritis : a prospective longitudinal inception cohort study

  • Artikel/kapitelEngelska2019

Förlag, utgivningsår, omfång ...

  • 2019-09-03
  • BMJ Publishing Group Ltd,2019
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-165746
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-165746URI
  • https://doi.org/10.1136/rmdopen-2019-000946DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-398011URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:145317752URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Introduction: Anticitrullinated peptide antibody (ACPA) responses for 22 citrullinated peptides in patients with early rheumatoid arthritis (RA) were analysed and related to radiological and clinical outcome during the first 2 years in a prospective inception cohort.Methods: The ACPA reactivities were assessed in 1022 patients with early RA (symptoms <12 months) using the custom-made microarray chip (Thermo Fisher Scientific, Uppsala, Sweden) in a prospective longitudinal study of observational assessments of Disease Activity Score (DAS28 and its components) and radiology during the first 24 months, accounting for the treatment.Results: Frequency of ACPA reactivities varied between 13.3% and 63.1%. Of the anticyclic citrullinated peptide-2 (anti-CCP2) antibody-negative patients, ACPA reactivities were positive in 32.6%. Smoking, human leucocyte antigen-shared epitope (HLA-SE), anti-CCP2/rheumatoid factor, protein tyrosine phosphatase non-receptor type 22 (1858C/T) and DAS28 were significantly associated with number of ACPA reactivities. The ACPA reactivities modified differently the development of DAS28 over 24 months (identified using trajectories). Anti-Filaggrin307-324, anti-hnRNP (Peptide)-Z1 and anti-F4-CIT-R antibodies anticipated lower DAS28 values (p<0.01–0.05), while positivity for anti-Fibrinogen(Fib)β62-78(74), and anti-Fibα563-583 predicted higher DAS28 (p<0.01 both). Interaction between anti-Fibß36-52, anti-Pept-5 and anti-Bla-26 antibodies, respectively, and DAS28 during 24 months decreased significantly the DAS28 values (p<0.01–0.05). Corticosteroids and biologicals were related to DAS28-area under the curve and Larsen score 24 months. Anti-vimentin2-17 antibodies remained significantly associated with Larsen score at baseline and 24 months, respectively, and radiological progression, besides biologicals at 24 months adjusted for sex and age.Conclusions: Several ACPA reactivities modified significantly the DAS28 development during the first 24 months and were significantly associated with Larsen score at baseline, 24 months and radiological progression.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Brink, MikaelUmeå universitet,Reumatologi,Umea Univ, Dept Publ Hlth & Clin Med Rheumatol, Umea, Sweden(Swepub:umu)mibr0003 (författare)
  • Lundquist, Anders,1978-Umeå universitet,Statistik,Umea Univ, Dept Stat, Umea, Sweden(Swepub:umu)anslst97 (författare)
  • Hansson, MonicaKarolinska Institutet (författare)
  • Mathsson Alm, LindaUppsala universitet,Klinisk immunologi,Thermo Fisher Sci, Uppsala, Sweden(Swepub:uu)limat990 (författare)
  • Rönnelid, JohanUppsala universitet,Klinisk immunologi(Swepub:uu)joharonn (författare)
  • Berglin, Ewa,MD, PhD,1955-Umeå universitet,Reumatologi,Umea Univ, Dept Publ Hlth & Clin Med Rheumatol, Umea, Sweden(Swepub:umu)evbe0009 (författare)
  • Holmdahl, RikardKarolinska Institutet (författare)
  • Skriner, KarlCharite Univ Med Berlin, Campus Charite Mitte, Berlin, Germany (författare)
  • Serre, GuyUniv Toulouse, Epithelial Differentat & Rheumatoid Autoimmun Uni, UMRS, Toulouse, France (författare)
  • Klareskog, LarsKarolinska Institutet (författare)
  • Rantapää-Dahlqvist, SolbrittUmeå universitet,Reumatologi,Umea Univ, Dept Publ Hlth & Clin Med Rheumatol, Umea, Sweden(Swepub:umu)sora0001 (författare)
  • Umeå universitetReumatologi (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:RMD Open: BMJ Publishing Group Ltd5:22056-5933

Internetlänk

Hitta via bibliotek

  • RMD Open (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy