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Antibodies against citrullinated peptides are associated with clinical and radiological outcomes in patients with early rheumatoid arthritis : a prospective longitudinal inception cohort study
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- Boman, Antonia (author)
- Umeå universitet,Reumatologi,Umea Univ, Dept Publ Hlth & Clin Med Rheumatol, Umea, Sweden
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- Brink, Mikael (author)
- Umeå universitet,Reumatologi,Umea Univ, Dept Publ Hlth & Clin Med Rheumatol, Umea, Sweden
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- Lundquist, Anders, 1978- (author)
- Umeå universitet,Statistik,Umea Univ, Dept Stat, Umea, Sweden
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- Hansson, Monica (author)
- Karolinska Institutet
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- Mathsson Alm, Linda (author)
- Uppsala universitet,Klinisk immunologi,Thermo Fisher Sci, Uppsala, Sweden
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- Rönnelid, Johan (author)
- Uppsala universitet,Klinisk immunologi
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- Berglin, Ewa, MD, PhD, 1955- (author)
- Umeå universitet,Reumatologi,Umea Univ, Dept Publ Hlth & Clin Med Rheumatol, Umea, Sweden
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- Holmdahl, Rikard (author)
- Karolinska Institutet
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- Skriner, Karl (author)
- Charite Univ Med Berlin, Campus Charite Mitte, Berlin, Germany
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- Serre, Guy (author)
- Univ Toulouse, Epithelial Differentat & Rheumatoid Autoimmun Uni, UMRS, Toulouse, France
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- Klareskog, Lars (author)
- Karolinska Institutet
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- Rantapää-Dahlqvist, Solbritt (author)
- Umeå universitet,Reumatologi,Umea Univ, Dept Publ Hlth & Clin Med Rheumatol, Umea, Sweden
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(creator_code:org_t)
- 2019-09-03
- 2019
- English.
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In: RMD Open. - : BMJ Publishing Group Ltd. - 2056-5933. ; 5:2
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Abstract
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- Introduction: Anticitrullinated peptide antibody (ACPA) responses for 22 citrullinated peptides in patients with early rheumatoid arthritis (RA) were analysed and related to radiological and clinical outcome during the first 2 years in a prospective inception cohort.Methods: The ACPA reactivities were assessed in 1022 patients with early RA (symptoms <12 months) using the custom-made microarray chip (Thermo Fisher Scientific, Uppsala, Sweden) in a prospective longitudinal study of observational assessments of Disease Activity Score (DAS28 and its components) and radiology during the first 24 months, accounting for the treatment.Results: Frequency of ACPA reactivities varied between 13.3% and 63.1%. Of the anticyclic citrullinated peptide-2 (anti-CCP2) antibody-negative patients, ACPA reactivities were positive in 32.6%. Smoking, human leucocyte antigen-shared epitope (HLA-SE), anti-CCP2/rheumatoid factor, protein tyrosine phosphatase non-receptor type 22 (1858C/T) and DAS28 were significantly associated with number of ACPA reactivities. The ACPA reactivities modified differently the development of DAS28 over 24 months (identified using trajectories). Anti-Filaggrin307-324, anti-hnRNP (Peptide)-Z1 and anti-F4-CIT-R antibodies anticipated lower DAS28 values (p<0.01–0.05), while positivity for anti-Fibrinogen(Fib)β62-78(74), and anti-Fibα563-583 predicted higher DAS28 (p<0.01 both). Interaction between anti-Fibß36-52, anti-Pept-5 and anti-Bla-26 antibodies, respectively, and DAS28 during 24 months decreased significantly the DAS28 values (p<0.01–0.05). Corticosteroids and biologicals were related to DAS28-area under the curve and Larsen score 24 months. Anti-vimentin2-17 antibodies remained significantly associated with Larsen score at baseline and 24 months, respectively, and radiological progression, besides biologicals at 24 months adjusted for sex and age.Conclusions: Several ACPA reactivities modified significantly the DAS28 development during the first 24 months and were significantly associated with Larsen score at baseline, 24 months and radiological progression.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Boman, Antonia
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Brink, Mikael
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Lundquist, Ander ...
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Hansson, Monica
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Mathsson Alm, Li ...
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Rönnelid, Johan
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Berglin, Ewa, MD ...
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Holmdahl, Rikard
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Skriner, Karl
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Serre, Guy
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Klareskog, Lars
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Rantapää-Dahlqvi ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Rheumatology and ...
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RMD Open
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Umeå University
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Uppsala University
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Karolinska Institutet