SwePub
Sök i LIBRIS databas

  Extended search

(WFRF:(van der Schouw Yvonne T.)) pers:(Sharp Stephen J.)
 

Search: (WFRF:(van der Schouw Yvonne T.)) pers:(Sharp Stephen J.) > (2020-2023) > Autoimmunity plays ...

  • Rolandsson, OlovUmeå University,Umeå universitet,Allmänmedicin (author)

Autoimmunity plays a role in the onset of diabetes after 40 years of age

  • Article/chapterEnglish2020

Publisher, publication year, extent ...

  • 2019-11-11
  • Springer,2020
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-165777
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-165777URI
  • https://doi.org/10.1007/s00125-019-05016-3DOI
  • https://lup.lub.lu.se/record/f5b26d6e-6ecc-4815-a453-bf8826d3b1f3URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Aims/hypothesis: Type 1 and type 2 diabetes differ with respect to pathophysiological factors such as beta cell function, insulin resistance and phenotypic appearance, but there may be overlap between the two forms of diabetes. However, there are relatively few prospective studies that have characterised the relationship between autoimmunity and incident diabetes. We investigated associations of antibodies against the 65 kDa isoform of GAD (GAD65) with type 1 diabetes and type 2 diabetes genetic risk scores and incident diabetes in adults in European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct, a case-cohort study nested in the EPIC cohort.Methods: GAD65 antibodies were analysed in EPIC participants (over 40 years of age and free of known diabetes at baseline) by radioligand binding assay in a random subcohort (n = 15,802) and in incident diabetes cases (n = 11,981). Type 1 diabetes and type 2 diabetes genetic risk scores were calculated. Associations between GAD65 antibodies and incident diabetes were estimated using Prentice-weighted Cox regression.Results: GAD65 antibody positivity at baseline was associated with development of diabetes during a median follow-up time of 10.9 years (HR for GAD65 antibody positive vs negative 1.78; 95% CI 1.43, 2.20) after adjustment for sex, centre, physical activity, smoking status and education. The genetic risk score for type 1 diabetes but not type 2 diabetes was associated with GAD65 antibody positivity in both the subcohort (OR per SD genetic risk 1.24; 95% CI 1.03, 1.50) and incident cases (OR 1.97; 95% CI 1.72, 2.26) after adjusting for age and sex. The risk of incident diabetes in those in the top tertile of the type 1 diabetes genetic risk score who were also GAD65 antibody positive was 3.23 (95% CI 2.10, 4.97) compared with all other individuals, suggesting that 1.8% of incident diabetes in adults was attributable to this combination of risk factors.Conclusions/interpretation: Our study indicates that incident diabetes in adults has an element of autoimmune aetiology. Thus, there might be a reason to re-evaluate the present subclassification of diabetes in adulthood.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Hampe, Christiane S.University of Washington (author)
  • Sharp, Stephen J.University of Cambridge,Institute of Metabolic Science (author)
  • Ardanaz, EvaCIBER Epidemiology and Public Health (CIBERESP),Health Research Institute of Navarra (IDISNA)(Swepub:lu)extLU-05 (author)
  • Boeing, HeinerGerman Institute of Human Nutrition (author)
  • Fagherazzi, GuyCentre for Research in Epidemiology and Population Health (CESP) (author)
  • Mancini, Francesca RomanaCentre for Research in Epidemiology and Population Health (CESP) (author)
  • Nilsson, Peter M.Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)medf-pni (author)
  • Overvad, KimAarhus University,Aalborg University Hospital (author)
  • Chirlaque, Maria-DoloresMurcia Regional Health Council,CIBER Epidemiology and Public Health (CIBERESP) (author)
  • Dorronsoro, MirenPublic Health Division of Gipuzkoa,Biodonostia Health Research Institute,CIBER Epidemiology and Public Health (CIBERESP) (author)
  • Gunter, Marc J.International Agency for Research on Cancer, World Health Organization (author)
  • Kaaks, RudolfGerman Cancer Research Centre (author)
  • Key, Timothy J.University of Oxford (author)
  • Khaw, Kay-TeeAddenbrooke's Hospital,University of Cambridge (author)
  • Krogh, VittorioIstituto Nazionale dei Tumori (author)
  • Kuehn, TilmanGerman Cancer Research Centre (author)
  • Palli, DomenicoInstitute for Cancer Research, Prevention and Clinical Network (ISPRO) (author)
  • Panico, SalvatoreUniversity of Naples Federico II (author)
  • Sacerdote, CarlottaCitta' della Salute e della Scienza Hospital-University of Turin (author)
  • Sanchez, Maria-JoseCIBER Epidemiology and Public Health (CIBERESP),University of Granada,Andalusian School Of Public Health (EASP) (author)
  • Severi, GianlucaUniversity of Paris-Saclay,Centre for Research in Epidemiology and Population Health (CESP) (author)
  • Spijkerman, Annemieke M. W.National Institute for Public Health and the Environment (RIVM) (author)
  • Tumino, RosarioCivic and M.P Arezzo Hospital,Associazione Iblea per la Ricerca Epidemiologica (author)
  • van der Schouw, Yvonne T.University Medical Center Utrecht (author)
  • Riboli, ElioImperial College London (author)
  • Forouhi, Nita G.University of Cambridge (author)
  • Langenberg, ClaudiaInstitute of Metabolic Science,University of Cambridge (author)
  • Wareham, Nicholas J.University of Cambridge (author)
  • Umeå universitetAllmänmedicin (creator_code:org_t)

Related titles

  • In:Diabetologia: Springer63, s. 266-2770012-186X1432-0428

Internet link

Find in a library

To the university's database

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view