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Autoimmunity plays ...
Autoimmunity plays a role in the onset of diabetes after 40 years of age
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- Rolandsson, Olov (author)
- Umeå University,Umeå universitet,Allmänmedicin
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- Hampe, Christiane S. (author)
- University of Washington
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- Sharp, Stephen J. (author)
- University of Cambridge,Institute of Metabolic Science
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- Ardanaz, Eva (author)
- CIBER Epidemiology and Public Health (CIBERESP),Health Research Institute of Navarra (IDISNA)
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- Boeing, Heiner (author)
- German Institute of Human Nutrition
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- Fagherazzi, Guy (author)
- Centre for Research in Epidemiology and Population Health (CESP)
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- Mancini, Francesca Romana (author)
- Centre for Research in Epidemiology and Population Health (CESP)
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- Nilsson, Peter M. (author)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Skåne University Hospital
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- Overvad, Kim (author)
- Aalborg University Hospital,Aarhus University
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- Chirlaque, Maria-Dolores (author)
- Murcia Regional Health Council,CIBER Epidemiology and Public Health (CIBERESP)
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- Dorronsoro, Miren (author)
- Public Health Division of Gipuzkoa,Biodonostia Health Research Institute,CIBER Epidemiology and Public Health (CIBERESP)
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- Gunter, Marc J. (author)
- International Agency for Research on Cancer, World Health Organization
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- Kaaks, Rudolf (author)
- German Cancer Research Centre
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- Key, Timothy J. (author)
- University of Oxford
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- Khaw, Kay-Tee (author)
- University of Cambridge,Addenbrooke's Hospital
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- Krogh, Vittorio (author)
- Istituto Nazionale dei Tumori
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- Kuehn, Tilman (author)
- German Cancer Research Centre
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- Palli, Domenico (author)
- Institute for Cancer Research, Prevention and Clinical Network (ISPRO)
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- Panico, Salvatore (author)
- University of Naples Federico II
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- Sacerdote, Carlotta (author)
- Citta' della Salute e della Scienza Hospital-University of Turin
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- Sanchez, Maria-Jose (author)
- Andalusian School Of Public Health (EASP),University of Granada,CIBER Epidemiology and Public Health (CIBERESP)
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- Severi, Gianluca (author)
- University of Paris-Saclay,Centre for Research in Epidemiology and Population Health (CESP)
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- Spijkerman, Annemieke M. W. (author)
- National Institute for Public Health and the Environment (RIVM)
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- Tumino, Rosario (author)
- Civic and M.P Arezzo Hospital,L’ Associazione Iblea per la Ricerca Epidemiologica (A.I.R.E.)
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- van der Schouw, Yvonne T. (author)
- University Medical Center Utrecht
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- Riboli, Elio (author)
- Imperial College London
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- Forouhi, Nita G. (author)
- University of Cambridge
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- Langenberg, Claudia (author)
- Institute of Metabolic Science,University of Cambridge
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- Wareham, Nicholas J. (author)
- University of Cambridge
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(creator_code:org_t)
- 2019-11-11
- 2020
- English.
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In: Diabetologia. - : Springer. - 0012-186X .- 1432-0428. ; 63, s. 266-277
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Abstract
Subject headings
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- Aims/hypothesis: Type 1 and type 2 diabetes differ with respect to pathophysiological factors such as beta cell function, insulin resistance and phenotypic appearance, but there may be overlap between the two forms of diabetes. However, there are relatively few prospective studies that have characterised the relationship between autoimmunity and incident diabetes. We investigated associations of antibodies against the 65 kDa isoform of GAD (GAD65) with type 1 diabetes and type 2 diabetes genetic risk scores and incident diabetes in adults in European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct, a case-cohort study nested in the EPIC cohort.Methods: GAD65 antibodies were analysed in EPIC participants (over 40 years of age and free of known diabetes at baseline) by radioligand binding assay in a random subcohort (n = 15,802) and in incident diabetes cases (n = 11,981). Type 1 diabetes and type 2 diabetes genetic risk scores were calculated. Associations between GAD65 antibodies and incident diabetes were estimated using Prentice-weighted Cox regression.Results: GAD65 antibody positivity at baseline was associated with development of diabetes during a median follow-up time of 10.9 years (HR for GAD65 antibody positive vs negative 1.78; 95% CI 1.43, 2.20) after adjustment for sex, centre, physical activity, smoking status and education. The genetic risk score for type 1 diabetes but not type 2 diabetes was associated with GAD65 antibody positivity in both the subcohort (OR per SD genetic risk 1.24; 95% CI 1.03, 1.50) and incident cases (OR 1.97; 95% CI 1.72, 2.26) after adjusting for age and sex. The risk of incident diabetes in those in the top tertile of the type 1 diabetes genetic risk score who were also GAD65 antibody positive was 3.23 (95% CI 2.10, 4.97) compared with all other individuals, suggesting that 1.8% of incident diabetes in adults was attributable to this combination of risk factors.Conclusions/interpretation: Our study indicates that incident diabetes in adults has an element of autoimmune aetiology. Thus, there might be a reason to re-evaluate the present subclassification of diabetes in adulthood.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- Autoantibody
- Autoimmunity
- Genetic risk score
- Incident diabetes
- Type 1 diabetes
- Type 2 diabetes
- Autoantibody
- Autoimmunity
- Genetic risk score
- Incident diabetes
- Type 1 diabetes
- Type 2 diabetes
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Rolandsson, Olov
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Hampe, Christian ...
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Sharp, Stephen J ...
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Ardanaz, Eva
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Boeing, Heiner
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Fagherazzi, Guy
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show more...
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Mancini, Frances ...
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Nilsson, Peter M ...
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Overvad, Kim
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Chirlaque, Maria ...
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Dorronsoro, Mire ...
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Gunter, Marc J.
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Kaaks, Rudolf
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Key, Timothy J.
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Khaw, Kay-Tee
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Krogh, Vittorio
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Kuehn, Tilman
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Palli, Domenico
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Panico, Salvator ...
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Sacerdote, Carlo ...
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Sanchez, Maria-J ...
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Severi, Gianluca
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Spijkerman, Anne ...
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Tumino, Rosario
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van der Schouw, ...
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Riboli, Elio
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Forouhi, Nita G.
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Langenberg, Clau ...
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Wareham, Nichola ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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Diabetologia
- By the university
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Umeå University
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Lund University