SwePub
Sök i LIBRIS databas

  Extended search

id:"swepub:oai:DiVA.org:umu-165833"
 

Search: id:"swepub:oai:DiVA.org:umu-165833" > Complete avian mala...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
  • Böhme, Ulrike (author)

Complete avian malaria parasite genomes reveal features associated with lineage-specific evolution in birds and mammals

  • Article/chapterEnglish2018

Publisher, publication year, extent ...

  • 2018-03-02
  • Cold Spring Harbor Laboratory Press (CSHL),2018
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-165833
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-165833URI
  • https://doi.org/10.1101/gr.218123.116DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Avian malaria parasites are prevalent around the world and infect a wide diversity of bird species. Here, we report the sequencing and analysis of high-quality draft genome sequences for two avian malaria species, Plasmodium relictum and Plasmodium gallinaceum. We identify 50 genes that are specific to avian malaria, located in an otherwise conserved core of the genome that shares gene synteny with all other sequenced malaria genomes. Phylogenetic analysis suggests that the avian malaria species form an outgroup to the mammalian Plasmodium species, and using amino acid divergence between species, we estimate the avian- and mammalian-infective lineages diverged in the order of 10 million years ago. Consistent with their phylogenetic position, we identify orthologs of genes that had previously appeared to be restricted to the clades of parasites containing Plasmodium falciparum and Plasmodium vivax, the species with the greatest impact on human health. From these orthologs, we explore differential diversifying selection across the genus and show that the avian lineage is remarkable in the extent to which invasion-related genes are evolving. The subtelomeres of the P. relictum and P. gallinaceum genomes contain several novel gene families, including an expanded surf multigene family. We also identify an expansion of reticulocyte binding protein homologs in P. relictum, and within these proteins, we detect distinct regions that are specific to nonhuman primate, humans, rodent, and avian hosts. For the first time in the Plasmodium lineage, we find evidence of transposable elements, including several hundred fragments of LTR-retrotransposons in both species and an apparently complete LTR-retrotransposon in the genome of P. gallinaceum.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Otto, Thomas D. (author)
  • Cotton, James A. (author)
  • Steinbiss, Sascha (author)
  • Sanders, Mandy (author)
  • Oyola, Samuel O. (author)
  • Nicot, Antoine (author)
  • Gandon, Sylvain (author)
  • Patra, Kailash P. (author)
  • Herd, Colin (author)
  • Bushell, Ellen (author)
  • Modrzynska, Katarzyna K. (author)
  • Billker, OliverWellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, United Kingdom(Swepub:umu)olbi0005 (author)
  • Vinetz, Joseph M. (author)
  • Rivero, Ana (author)
  • Newbold, Chris I. (author)
  • Berriman, Matthew (author)
  • Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, United Kingdom (creator_code:org_t)

Related titles

  • In:Genome Research: Cold Spring Harbor Laboratory Press (CSHL)28:4, s. 547-5601088-90511549-5469

Internet link

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view