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  • Sasamoto, NaokoBrigham and Women's Hospital / Harvard Medical School (author)

Development and validation of circulating CA125 prediction models in postmenopausal women

  • Article/chapterEnglish2019

Publisher, publication year, extent ...

  • 2019-11-26
  • BioMed Central (BMC),2019
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-166388
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-166388URI
  • https://doi.org/10.1186/s13048-019-0591-4DOI
  • https://lup.lub.lu.se/record/6268a991-9387-48ba-8f89-47755e9fdeb2URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Background: Cancer Antigen 125 (CA125) is currently the best available ovarian cancer screening biomarker. However, CA125 has been limited by low sensitivity and specificity in part due to normal variation between individuals. Personal characteristics that influence CA125 could be used to improve its performance as screening biomarker.Methods: We developed and validated linear and dichotomous (>= 35 U/mL) circulating CA125 prediction models in postmenopausal women without ovarian cancer who participated in one of five large population-based studies: Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO, n = 26,981), European Prospective Investigation into Cancer and Nutrition (EPIC, n = 861), the Nurses' Health Studies (NHS/NHSII, n = 81), and the New England Case Control Study (NEC, n = 923). The prediction models were developed using stepwise regression in PLCO and validated in EPIC, NHS/NHSII and NEC. Result The linear CA125 prediction model, which included age, race, body mass index (BMI), smoking status and duration, parity, hysterectomy, age at menopause, and duration of hormone therapy (HT), explained 5% of the total variance of CA125. The correlation between measured and predicted CA125 was comparable in PLCO testing dataset (r = 0.18) and external validation datasets (r = 0.14). The dichotomous CA125 prediction model included age, race, BMI, smoking status and duration, hysterectomy, time since menopause, and duration of HT with AUC of 0.64 in PLCO and 0.80 in validation dataset.Conclusions: The linear prediction model explained a small portion of the total variability of CA125, suggesting the need to identify novel predictors of CA125. The dichotomous prediction model showed moderate discriminatory performance which validated well in independent dataset. Our dichotomous model could be valuable in identifying healthy women who may have elevated CA125 levels, which may contribute to reducing false positive tests using CA125 as screening biomarker.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Babic, AnaDana-Farber Cancer Institute (author)
  • Rosner, Bernard A.Brigham and Women's Hospital / Harvard Medical School,Harvard Medical School (author)
  • Fortner, Renee T.German Cancer Research Centre (author)
  • Vitonis, Allison F.Brigham and Women's Hospital / Harvard Medical School,Harvard Medical School (author)
  • Yamamoto, HidemiBrigham and Women's Hospital / Harvard Medical School (author)
  • Fichorova, Raina N.Brigham and Women's Hospital / Harvard Medical School (author)
  • Titus, Linda J.Dartmouth College,Norris Cotton Cancer Center (author)
  • Tjonneland, AnneDanish Cancer Society,University of Copenhagen (author)
  • Hansen, LouiseDanish Cancer Society (author)
  • Kvaskoff, MarinaCentre for Research in Epidemiology and Population Health (CESP),Institut Gustave Roussy (author)
  • Fournier, AgnesCentre for Research in Epidemiology and Population Health (CESP),Institut Gustave Roussy (author)
  • Mancini, Francesca RomanaInstitut Gustave Roussy,Centre for Research in Epidemiology and Population Health (CESP) (author)
  • Boeing, HeinerGerman Institute of Human Nutrition (author)
  • Trichopoulou, AntoniaHellenic Health Foundation, Athens,National and Kapodistrian University of Athens (author)
  • Peppa, EleniHellenic Health Foundation, Athens (author)
  • Karakatsani, AnnaNational and Kapodistrian University of Athens,Hellenic Health Foundation, Athens (author)
  • Palli, DomenicoInstitute for Cancer Research, Prevention and Clinical Network (ISPRO) (author)
  • Grioni, SaraIstituto Nazionale dei Tumori (author)
  • Mattiello, AmaliaUniversity of Naples Federico II (author)
  • Tumino, RosarioCivic and M.P Arezzo Hospital (author)
  • Fiano, ValentinaUniversity of Turin (author)
  • Onland-Moret, N. CharlotteUniversity Medical Center Utrecht,Utrecht University (author)
  • Weiderpass, ElisabeteInternational Agency for Research on Cancer, World Health Organization (author)
  • Gram, Inger T.UiT The Arctic University of Norway, Tromsø (author)
  • Quiros, J. RamonPublic Health Directorate (author)
  • Lujan-Barroso, LeilaBellvitge University Hospital-IDIBELL,Catalan Institute of Oncology (author)
  • Sanchez, Maria-JoseUniversity of Granada,Andalusian School Of Public Health (EASP),CIBER Epidemiology and Public Health (CIBERESP) (author)
  • Colorado-Yohar, SandraUniversity of Antioquia,CIBER Epidemiology and Public Health (CIBERESP),Murcia Regional Health Council (author)
  • Barricarte, AurelioCIBER Epidemiology and Public Health (CIBERESP) (author)
  • Amiano, PilarCIBER Epidemiology and Public Health (CIBERESP) (author)
  • Idahl, Annika,1965-Umeå University,Umeå universitet,Obstetrik och gynekologi(Swepub:umu)anid0002 (author)
  • Lundin, EvaUmeå University,Umeå universitet,Patologi(Swepub:umu)evlu0001 (author)
  • Sartor, HannaLund University,Lunds universitet,Diagnostisk radiologi, Malmö,Forskargrupper vid Lunds universitet,Radiology Diagnostics, Malmö,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-hso (author)
  • Khaw, Kay-TeeUniversity of Cambridge (author)
  • Key, Timothy J.University of Oxford (author)
  • Muller, DavidImperial College London (author)
  • Riboli, ElioImperial College London (author)
  • Gunter, MarcInternational Agency for Research on Cancer, World Health Organization (author)
  • Dossus, LaureInternational Agency for Research on Cancer, World Health Organization (author)
  • Trabert, BrittonNational Cancer Institute, USA (author)
  • Wentzensen, NicolasNational Cancer Institute, USA (author)
  • Kaaks, RudolfGerman Cancer Research Centre (author)
  • Cramer, Daniel W.Brigham and Women's Hospital / Harvard Medical School,Harvard Medical School (author)
  • Tworoger, Shelley S.Harvard University,H. Lee Moffitt Cancer Center & Research Institute (author)
  • Terry, Kathryn L.Harvard University,Brigham and Women's Hospital / Harvard Medical School (author)
  • Brigham and Women's Hospital / Harvard Medical SchoolDana-Farber Cancer Institute (creator_code:org_t)

Related titles

  • In:Journal of Ovarian Research: BioMed Central (BMC)12:11757-2215

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