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A multi-ancestry ge...
A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure
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Sung, Yun Ju (author)
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de Las Fuentes, Lisa (author)
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Winkler, Thomas W. (author)
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show more...
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Chasman, Daniel, I (author)
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Bentley, Amy R. (author)
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Kraja, Aldi T. (author)
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Ntalla, Ioanna (author)
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Warren, Helen R. (author)
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Guo, Xiuqing (author)
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Schwander, Karen (author)
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Manning, Alisa K. (author)
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Brown, Michael R. (author)
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Aschard, Hugues (author)
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Feitosa, Mary F. (author)
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Franceschini, Nora (author)
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Lu, Yingchang (author)
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Cheng, Ching-Yu (author)
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Sim, Xueling (author)
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Vojinovic, Dina (author)
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Marten, Jonathan (author)
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Musani, Solomon K. (author)
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Kilpelainen, Tuomas O. (author)
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Richard, Melissa A. (author)
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Aslibekyan, Stella (author)
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Bartz, Traci M. (author)
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Dorajoo, Rajkumar (author)
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Li, Changwei (author)
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Liu, Yongmei (author)
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Rankinen, Tuomo (author)
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Smith, Albert Vernon (author)
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Tajuddin, Salman M. (author)
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Tayo, Bamidele O. (author)
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Zhao, Wei (author)
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Zhou, Yanhua (author)
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Matoba, Nana (author)
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Sofer, Tamar (author)
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Alver, Maris (author)
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Amini, Marzyeh (author)
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Boissel, Mathilde (author)
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Chai, Jin Fang (author)
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Chen, Xu (author)
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Divers, Jasmin (author)
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Gandin, Ilaria (author)
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Gao, Chuan (author)
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Giulianini, Franco (author)
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Goel, Anuj (author)
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Harris, Sarah E. (author)
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Hartwig, Fernando P. (author)
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He, Meian (author)
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Horimoto, Andrea R. V. R. (author)
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Hsu, Fang-Chi (author)
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Jackson, Anne U. (author)
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Kammerer, Candace M. (author)
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Kasturiratne, Anuradhani (author)
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- Komulainen, Pirjo (author)
- Karolinska Institutet
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Kuehnel, Brigitte (author)
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- Leander, Karin (author)
- Karolinska Institutet
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Lee, Wen-Jane (author)
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Lin, Keng-Hung (author)
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Luan, Jian'an (author)
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Lyytikainen, Leo-Pekka (author)
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McKenzie, Colin A. (author)
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Nelson, Christopher P. (author)
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Noordam, Raymond (author)
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Scott, Robert A. (author)
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Sheu, Wayne H. H. (author)
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Stancakova, Alena (author)
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Takeuchi, Fumihiko (author)
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van Der Most, Peter J. (author)
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Varga, Tibor V. (author)
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Waken, Robert J. (author)
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Wang, Heming (author)
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Wang, Yajuan (author)
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Ware, Erin B. (author)
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Weiss, Stefan (author)
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Wen, Wanqing (author)
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Yanek, Lisa R. (author)
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Zhang, Weihua (author)
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Zhao, Jing Hua (author)
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Afaq, Saima (author)
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Alfred, Tamuno (author)
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Amin, Najaf (author)
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Arking, Dan E. (author)
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Aung, Tin (author)
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Barr, R. Graham (author)
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Bielak, Lawrence F. (author)
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Boerwinkle, Eric (author)
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Bottinger, Erwin P. (author)
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Braund, Peter S. (author)
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Brody, Jennifer A. (author)
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Broeckel, Ulrich (author)
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Cade, Brian (author)
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Campbell, Archie (author)
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Canouil, Mickael (author)
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Chakravarti, Aravinda (author)
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Cocca, Massimiliano (author)
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Collins, Francis S. (author)
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Connell, John M. (author)
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de Mutsert, Renee (author)
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de Silva, H. Janaka (author)
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Doerr, Marcus (author)
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Duan, Qing (author)
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Eaton, Charles B. (author)
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Ehret, Georg (author)
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Evangelou, Evangelos (author)
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Faul, Jessica D. (author)
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Forouhi, Nita G. (author)
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Franco, Oscar H. (author)
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Friedlander, Yechiel (author)
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Gao, He (author)
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- Gigante, Bruna (author)
- Karolinska Institutet
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Gu, C. Charles (author)
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Gupta, Preeti (author)
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Hagenaars, Saskia P. (author)
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Harris, Tamara B. (author)
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He, Jiang (author)
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Heikkinen, Sami (author)
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Heng, Chew-Kiat (author)
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Hofman, Albert (author)
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Howard, Barbara, V (author)
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Hunt, Steven C. (author)
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Irvin, Marguerite R. (author)
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Jia, Yucheng (author)
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Katsuya, Tomohiro (author)
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Kaufman, Joel (author)
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Kerrison, Nicola D. (author)
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Khor, Chiea Chuen (author)
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Koh, Woon-Puay (author)
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Koistinen, Heikki A. (author)
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Kooperberg, Charles B. (author)
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Krieger, Jose E. (author)
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Kubo, Michiaki (author)
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Kutalik, Zoltan (author)
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Kuusisto, Johanna (author)
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Lakka, Timo A. (author)
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Langefeld, Carl D. (author)
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Langenberg, Claudia (author)
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Launer, Lenore J. (author)
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Lee, Joseph H. (author)
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Lehne, Benjamin (author)
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Levy, Daniel (author)
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Lewis, Cora E. (author)
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Li, Yize (author)
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Lim, Sing Hui (author)
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Liu, Ching-Ti (author)
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Liu, Jianjun (author)
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Liu, Jingmin (author)
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Liu, Yeheng (author)
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Loh, Marie (author)
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Lohman, Kurt K. (author)
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Louie, Tin (author)
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Magi, Reedik (author)
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Matsuda, Koichi (author)
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Meitinger, Thomas (author)
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Metspalu, Andres (author)
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Milani, Lili (author)
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Momozawa, Yukihide (author)
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Mosley, Thomas H., Jr. (author)
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Nalls, Mike A. (author)
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Nasri, Ubaydah (author)
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O'Connell, Jeff R. (author)
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Ogunniyi, Adesola (author)
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Palmas, Walter R. (author)
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Palmer, Nicholette D. (author)
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Pankow, James S. (author)
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- Pedersen, Nancy L. (author)
- Karolinska Institutet
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Peters, Annette (author)
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Peyser, Patricia A. (author)
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Polasek, Ozren (author)
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Porteous, David (author)
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Raitakari, Olli T. (author)
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- Renström, Frida (author)
- Umeå universitet,Enheten för biobanksforskning,Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Skåne University Hospital, Malmö, Sweden
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Rice, Treva K. (author)
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Ridker, Paul M. (author)
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Robino, Antonietta (author)
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Robinson, Jennifer G. (author)
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Rose, Lynda M. (author)
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Rudan, Igor (author)
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Sabanayagam, Charumathi (author)
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Salako, Babatunde L. (author)
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Sandow, Kevin (author)
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Schmidt, Carsten O. (author)
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Schreiner, Pamela J. (author)
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Scott, William R. (author)
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Sever, Peter (author)
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Sims, Mario (author)
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Sitlani, Colleen M. (author)
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Smith, Blair H. (author)
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Smith, Jennifer A. (author)
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Snieder, Harold (author)
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Starr, John M. (author)
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Strauch, Konstantin (author)
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Tang, Hua (author)
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Taylor, Kent D. (author)
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Teo, Yik Ying (author)
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Tham, Yih Chung (author)
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Uitterlinden, Andre G. (author)
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Waldenberger, Melanie (author)
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Wang, Lihua (author)
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Wang, Ya Xing (author)
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Wei, Wen Bin (author)
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Wilson, Gregory (author)
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Wojczynski, Mary K. (author)
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Xiang, Yong-Bing (author)
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Yao, Jie (author)
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Yu, Caizheng (author)
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Yuan, Jian-Min (author)
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Zonderman, Alan B. (author)
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Becker, Diane M. (author)
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Boehnke, Michael (author)
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Bowden, Donald W. (author)
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Chambers, John C. (author)
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Chen, Yii-Der Ida (author)
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Weir, David R. (author)
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- de Faire, Ulf (author)
- Karolinska Institutet
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Deary, Ian J. (author)
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Esko, Tonu (author)
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Farrall, Martin (author)
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Forrester, Terrence (author)
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Freedman, Barry, I (author)
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Froguel, Philippe (author)
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Gasparini, Paolo (author)
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Gieger, Christian (author)
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Horta, Bernardo Lessa (author)
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Hung, Yi-Jen (author)
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Jonas, Jost Bruno (author)
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Kato, Norihiro (author)
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Kooner, Jaspal S. (author)
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Laakso, Markku (author)
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Lehtimaki, Terho (author)
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Liang, Kae-Woei (author)
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Magnusson, Patrik K. E. (author)
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Oldehinkel, Albertine J. (author)
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Pereira, Alexandre C. (author)
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Perls, Thomas (author)
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Rauramaa, Rainer (author)
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Redline, Susan (author)
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Rettig, Rainer (author)
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Samani, Nilesh J. (author)
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Scott, James (author)
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Shu, Xiao-Ou (author)
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van Der Harst, Pim (author)
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Wagenknecht, Lynne E. (author)
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Wareham, Nicholas J. (author)
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Watkins, Hugh (author)
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Wickremasinghe, Ananda R. (author)
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Wu, Tangchun (author)
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Kamatani, Yoichiro (author)
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Laurie, Cathy C. (author)
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Bouchard, Claude (author)
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Cooper, Richard S. (author)
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Evans, Michele K. (author)
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Gudnason, Vilmundur (author)
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Hixson, James (author)
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Kardia, Sharon L. R. (author)
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Kritchevsky, Stephen B. (author)
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Psaty, Bruce M. (author)
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van Dam, Rob M. (author)
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Arnett, Donna K. (author)
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Mook-Kanamori, Dennis O. (author)
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Fornage, Myriam (author)
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Fox, Ervin R. (author)
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Hayward, Caroline (author)
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van Duijn, Cornelia M. (author)
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Tai, E. Shyong (author)
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Wong, Tien Yin (author)
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Loos, Ruth J. F. (author)
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Reiner, Alex P. (author)
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Rotimi, Charles N. (author)
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Bierut, Laura J. (author)
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Zhu, Xiaofeng (author)
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Cupples, L. Adrienne (author)
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Province, Michael A. (author)
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Rotter, Jerome, I (author)
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- Franks, Paul W. (author)
- Umeå universitet,Avdelningen för medicin,Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Skåne University Hospital, Malmö, Sweden; Harvard T. H. Chan School of Public Health, Department of Nutrition, Harvard University, Boston, MA, USA
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Rice, Kenneth (author)
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Elliott, Paul (author)
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Caulfield, Mark J. (author)
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Gauderman, W. James (author)
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Munroe, Patricia B. (author)
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Rao, Dabeeru C. (author)
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Morrison, Alanna C. (author)
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(creator_code:org_t)
- 2019-04-10
- 2019
- English.
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In: Human Molecular Genetics. - : Oxford University Press. - 0964-6906 .- 1460-2083. ; 28:15, s. 2615-2633
- Related links:
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https://www.ncbi.nlm...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Subject headings
Close
- Elevated blood pressure (BP), a leading cause of global morbidity and mortality, is influenced by both genetic and lifestyle factors. Cigarette smoking is one such lifestyle factor. Across five ancestries, we performed a genome-wide gene–smoking interaction study of mean arterial pressure (MAP) and pulse pressure (PP) in 129 913 individuals in stage 1 and follow-up analysis in 480 178 additional individuals in stage 2. We report here 136 loci significantly associated with MAP and/or PP. Of these, 61 were previously published through main-effect analysis of BP traits, 37 were recently reported by us for systolic BP and/or diastolic BP through gene–smoking interaction analysis and 38 were newly identified (P < 5 × 10−8, false discovery rate < 0.05). We also identified nine new signals near known loci. Of the 136 loci, 8 showed significant interaction with smoking status. They include CSMD1 previously reported for insulin resistance and BP in the spontaneously hypertensive rats. Many of the 38 new loci show biologic plausibility for a role in BP regulation. SLC26A7 encodes a chloride/bicarbonate exchanger expressed in the renal outer medullary collecting duct. AVPR1A is widely expressed, including in vascular smooth muscle cells, kidney, myocardium and brain. FHAD1 is a long non-coding RNA overexpressed in heart failure. TMEM51 was associated with contractile function in cardiomyocytes. CASP9 plays a central role in cardiomyocyte apoptosis. Identified only in African ancestry were 30 novel loci. Our findings highlight the value of multi-ancestry investigations, particularly in studies of interaction with lifestyle factors, where genomic and lifestyle differences may contribute to novel findings.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Keyword
- smoking
- hypertension
- genes
- genome
- life style
- genetics
- kidney
- mean arterial pressure
- blood pressure regulation
- pulse pressure
- genome-wide association study
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Sung, Yun Ju
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de Las Fuentes, ...
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Winkler, Thomas ...
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Chasman, Daniel, ...
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Bentley, Amy R.
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Kraja, Aldi T.
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show more...
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Ntalla, Ioanna
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Warren, Helen R.
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Guo, Xiuqing
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Schwander, Karen
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Manning, Alisa K ...
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Brown, Michael R ...
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Aschard, Hugues
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Feitosa, Mary F.
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Franceschini, No ...
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Lu, Yingchang
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Cheng, Ching-Yu
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Sim, Xueling
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Vojinovic, Dina
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Marten, Jonathan
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Musani, Solomon ...
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Kilpelainen, Tuo ...
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Richard, Melissa ...
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Aslibekyan, Stel ...
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Bartz, Traci M.
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Dorajoo, Rajkuma ...
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Li, Changwei
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Liu, Yongmei
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Rankinen, Tuomo
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Smith, Albert Ve ...
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Tajuddin, Salman ...
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Tayo, Bamidele O ...
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Zhao, Wei
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Zhou, Yanhua
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Matoba, Nana
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Sofer, Tamar
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Alver, Maris
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Amini, Marzyeh
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Boissel, Mathild ...
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Chai, Jin Fang
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Chen, Xu
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Divers, Jasmin
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Gandin, Ilaria
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Gao, Chuan
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Giulianini, Fran ...
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Goel, Anuj
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Harris, Sarah E.
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Hartwig, Fernand ...
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He, Meian
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Horimoto, Andrea ...
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Hsu, Fang-Chi
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Jackson, Anne U.
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Kammerer, Candac ...
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Kasturiratne, An ...
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Komulainen, Pirj ...
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Kuehnel, Brigitt ...
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Leander, Karin
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Lee, Wen-Jane
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Lin, Keng-Hung
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Luan, Jian'an
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Lyytikainen, Leo ...
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McKenzie, Colin ...
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Nelson, Christop ...
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Noordam, Raymond
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Scott, Robert A.
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Sheu, Wayne H. H ...
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Stancakova, Alen ...
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Takeuchi, Fumihi ...
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van Der Most, Pe ...
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Varga, Tibor V.
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Waken, Robert J.
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Wang, Heming
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Wang, Yajuan
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Ware, Erin B.
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Weiss, Stefan
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Wen, Wanqing
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Yanek, Lisa R.
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Zhang, Weihua
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Zhao, Jing Hua
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Afaq, Saima
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Alfred, Tamuno
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Amin, Najaf
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Arking, Dan E.
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Aung, Tin
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Barr, R. Graham
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Bielak, Lawrence ...
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Boerwinkle, Eric
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Bottinger, Erwin ...
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Braund, Peter S.
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Brody, Jennifer ...
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Broeckel, Ulrich
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Cade, Brian
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Campbell, Archie
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Canouil, Mickael
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Chakravarti, Ara ...
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Cocca, Massimili ...
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Collins, Francis ...
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Connell, John M.
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de Mutsert, Rene ...
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de Silva, H. Jan ...
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Doerr, Marcus
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Duan, Qing
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Eaton, Charles B ...
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Ehret, Georg
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Evangelou, Evang ...
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Faul, Jessica D.
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Forouhi, Nita G.
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Franco, Oscar H.
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Friedlander, Yec ...
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Gao, He
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Gigante, Bruna
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Gu, C. Charles
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Gupta, Preeti
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Hagenaars, Saski ...
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Harris, Tamara B ...
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He, Jiang
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Heikkinen, Sami
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Heng, Chew-Kiat
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Hofman, Albert
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Howard, Barbara, ...
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Hunt, Steven C.
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Irvin, Marguerit ...
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Jia, Yucheng
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Katsuya, Tomohir ...
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Kaufman, Joel
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Kerrison, Nicola ...
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Khor, Chiea Chue ...
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Koh, Woon-Puay
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Koistinen, Heikk ...
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Kooperberg, Char ...
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Krieger, Jose E.
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Kubo, Michiaki
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Kutalik, Zoltan
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Kuusisto, Johann ...
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Lakka, Timo A.
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Langefeld, Carl ...
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Langenberg, Clau ...
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Launer, Lenore J ...
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Lee, Joseph H.
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Lehne, Benjamin
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Levy, Daniel
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Lewis, Cora E.
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Li, Yize
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Lim, Sing Hui
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Liu, Ching-Ti
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Liu, Jianjun
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Liu, Jingmin
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Liu, Yeheng
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Loh, Marie
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Lohman, Kurt K.
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Louie, Tin
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Magi, Reedik
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Matsuda, Koichi
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Meitinger, Thoma ...
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Metspalu, Andres
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Milani, Lili
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Momozawa, Yukihi ...
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Mosley, Thomas H ...
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Nalls, Mike A.
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Nasri, Ubaydah
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O'Connell, Jeff ...
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Ogunniyi, Adesol ...
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Palmas, Walter R ...
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Palmer, Nicholet ...
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Pankow, James S.
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Pedersen, Nancy ...
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Peters, Annette
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Peyser, Patricia ...
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Polasek, Ozren
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Porteous, David
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Raitakari, Olli ...
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Renström, Frida
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Rice, Treva K.
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Ridker, Paul M.
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Robino, Antoniet ...
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Robinson, Jennif ...
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Rose, Lynda M.
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Rudan, Igor
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Sabanayagam, Cha ...
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Salako, Babatund ...
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Sandow, Kevin
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Schmidt, Carsten ...
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Schreiner, Pamel ...
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Scott, William R ...
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Sever, Peter
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Sims, Mario
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Sitlani, Colleen ...
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Smith, Blair H.
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Smith, Jennifer ...
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Snieder, Harold
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Starr, John M.
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Strauch, Konstan ...
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Tang, Hua
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Taylor, Kent D.
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Teo, Yik Ying
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Tham, Yih Chung
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Uitterlinden, An ...
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Waldenberger, Me ...
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Wang, Lihua
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Wang, Ya Xing
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Wei, Wen Bin
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Wilson, Gregory
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Wojczynski, Mary ...
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Xiang, Yong-Bing
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Yao, Jie
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Yu, Caizheng
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Yuan, Jian-Min
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Zonderman, Alan ...
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Becker, Diane M.
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Boehnke, Michael
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Bowden, Donald W ...
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Chambers, John C ...
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Chen, Yii-Der Id ...
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Weir, David R.
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de Faire, Ulf
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Deary, Ian J.
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Esko, Tonu
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Farrall, Martin
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Forrester, Terre ...
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Freedman, Barry, ...
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Froguel, Philipp ...
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Gasparini, Paolo
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Gieger, Christia ...
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Horta, Bernardo ...
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Hung, Yi-Jen
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Jonas, Jost Brun ...
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Kato, Norihiro
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Kooner, Jaspal S ...
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Laakso, Markku
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Lehtimaki, Terho
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Liang, Kae-Woei
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Magnusson, Patri ...
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Oldehinkel, Albe ...
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Pereira, Alexand ...
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Perls, Thomas
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Rauramaa, Rainer
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Redline, Susan
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Rettig, Rainer
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Samani, Nilesh J ...
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Scott, James
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Shu, Xiao-Ou
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van Der Harst, P ...
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Wagenknecht, Lyn ...
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Wareham, Nichola ...
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Watkins, Hugh
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Wickremasinghe, ...
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Wu, Tangchun
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Kamatani, Yoichi ...
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Laurie, Cathy C.
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Bouchard, Claude
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Cooper, Richard ...
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Evans, Michele K ...
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Gudnason, Vilmun ...
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Hixson, James
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Kardia, Sharon L ...
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Kritchevsky, Ste ...
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Psaty, Bruce M.
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van Dam, Rob M.
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Arnett, Donna K.
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Mook-Kanamori, D ...
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Fornage, Myriam
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Fox, Ervin R.
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Hayward, Carolin ...
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van Duijn, Corne ...
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Tai, E. Shyong
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Wong, Tien Yin
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Loos, Ruth J. F.
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Reiner, Alex P.
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Rotimi, Charles ...
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Bierut, Laura J.
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Zhu, Xiaofeng
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Cupples, L. Adri ...
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Province, Michae ...
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Rotter, Jerome, ...
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Franks, Paul W.
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Rice, Kenneth
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Elliott, Paul
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Caulfield, Mark ...
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Gauderman, W. Ja ...
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Munroe, Patricia ...
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Rao, Dabeeru C.
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Morrison, Alanna ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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Human Molecular ...
- By the university
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Umeå University
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Karolinska Institutet