Search: (WFRF:(Starr John M.)) pers:(Smith Jennifer A) pers:(Amin Najaf) >
A multi-ancestry ge...
A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure
- Article/chapterEnglish2019
Publisher, publication year, extent ...
-
2019-04-10
-
Oxford University Press,2019
-
printrdacarrier
Numbers
-
LIBRIS-ID:oai:DiVA.org:umu-166416
-
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-166416URI
-
https://doi.org/10.1093/hmg/ddz070DOI
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:142200157URI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
Elevated blood pressure (BP), a leading cause of global morbidity and mortality, is influenced by both genetic and lifestyle factors. Cigarette smoking is one such lifestyle factor. Across five ancestries, we performed a genome-wide gene–smoking interaction study of mean arterial pressure (MAP) and pulse pressure (PP) in 129 913 individuals in stage 1 and follow-up analysis in 480 178 additional individuals in stage 2. We report here 136 loci significantly associated with MAP and/or PP. Of these, 61 were previously published through main-effect analysis of BP traits, 37 were recently reported by us for systolic BP and/or diastolic BP through gene–smoking interaction analysis and 38 were newly identified (P < 5 × 10−8, false discovery rate < 0.05). We also identified nine new signals near known loci. Of the 136 loci, 8 showed significant interaction with smoking status. They include CSMD1 previously reported for insulin resistance and BP in the spontaneously hypertensive rats. Many of the 38 new loci show biologic plausibility for a role in BP regulation. SLC26A7 encodes a chloride/bicarbonate exchanger expressed in the renal outer medullary collecting duct. AVPR1A is widely expressed, including in vascular smooth muscle cells, kidney, myocardium and brain. FHAD1 is a long non-coding RNA overexpressed in heart failure. TMEM51 was associated with contractile function in cardiomyocytes. CASP9 plays a central role in cardiomyocyte apoptosis. Identified only in African ancestry were 30 novel loci. Our findings highlight the value of multi-ancestry investigations, particularly in studies of interaction with lifestyle factors, where genomic and lifestyle differences may contribute to novel findings.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
de Las Fuentes, Lisa
(author)
-
Winkler, Thomas W.
(author)
-
Chasman, Daniel, I
(author)
-
Bentley, Amy R.
(author)
-
Kraja, Aldi T.
(author)
-
Ntalla, Ioanna
(author)
-
Warren, Helen R.
(author)
-
Guo, Xiuqing
(author)
-
Schwander, Karen
(author)
-
Manning, Alisa K.
(author)
-
Brown, Michael R.
(author)
-
Aschard, Hugues
(author)
-
Feitosa, Mary F.
(author)
-
Franceschini, Nora
(author)
-
Lu, Yingchang
(author)
-
Cheng, Ching-Yu
(author)
-
Sim, Xueling
(author)
-
Vojinovic, Dina
(author)
-
Marten, Jonathan
(author)
-
Musani, Solomon K.
(author)
-
Kilpelainen, Tuomas O.
(author)
-
Richard, Melissa A.
(author)
-
Aslibekyan, Stella
(author)
-
Bartz, Traci M.
(author)
-
Dorajoo, Rajkumar
(author)
-
Li, Changwei
(author)
-
Liu, Yongmei
(author)
-
Rankinen, Tuomo
(author)
-
Smith, Albert Vernon
(author)
-
Tajuddin, Salman M.
(author)
-
Tayo, Bamidele O.
(author)
-
Zhao, Wei
(author)
-
Zhou, Yanhua
(author)
-
Matoba, Nana
(author)
-
Sofer, Tamar
(author)
-
Alver, Maris
(author)
-
Amini, Marzyeh
(author)
-
Boissel, Mathilde
(author)
-
Chai, Jin Fang
(author)
-
Chen, Xu
(author)
-
Divers, Jasmin
(author)
-
Gandin, Ilaria
(author)
-
Gao, Chuan
(author)
-
Giulianini, Franco
(author)
-
Goel, Anuj
(author)
-
Harris, Sarah E.
(author)
-
Hartwig, Fernando P.
(author)
-
He, Meian
(author)
-
Horimoto, Andrea R. V. R.
(author)
-
Hsu, Fang-Chi
(author)
-
Jackson, Anne U.
(author)
-
Kammerer, Candace M.
(author)
-
Kasturiratne, Anuradhani
(author)
-
Komulainen, PirjoKarolinska Institutet
(author)
-
Kuehnel, Brigitte
(author)
-
Leander, KarinKarolinska Institutet
(author)
-
Lee, Wen-Jane
(author)
-
Lin, Keng-Hung
(author)
-
Luan, Jian'an
(author)
-
Lyytikainen, Leo-Pekka
(author)
-
McKenzie, Colin A.
(author)
-
Nelson, Christopher P.
(author)
-
Noordam, Raymond
(author)
-
Scott, Robert A.
(author)
-
Sheu, Wayne H. H.
(author)
-
Stancakova, Alena
(author)
-
Takeuchi, Fumihiko
(author)
-
van Der Most, Peter J.
(author)
-
Varga, Tibor V.
(author)
-
Waken, Robert J.
(author)
-
Wang, Heming
(author)
-
Wang, Yajuan
(author)
-
Ware, Erin B.
(author)
-
Weiss, Stefan
(author)
-
Wen, Wanqing
(author)
-
Yanek, Lisa R.
(author)
-
Zhang, Weihua
(author)
-
Zhao, Jing Hua
(author)
-
Afaq, Saima
(author)
-
Alfred, Tamuno
(author)
-
Amin, Najaf
(author)
-
Arking, Dan E.
(author)
-
Aung, Tin
(author)
-
Barr, R. Graham
(author)
-
Bielak, Lawrence F.
(author)
-
Boerwinkle, Eric
(author)
-
Bottinger, Erwin P.
(author)
-
Braund, Peter S.
(author)
-
Brody, Jennifer A.
(author)
-
Broeckel, Ulrich
(author)
-
Cade, Brian
(author)
-
Campbell, Archie
(author)
-
Canouil, Mickael
(author)
-
Chakravarti, Aravinda
(author)
-
Cocca, Massimiliano
(author)
-
Collins, Francis S.
(author)
-
Connell, John M.
(author)
-
de Mutsert, Renee
(author)
-
de Silva, H. Janaka
(author)
-
Doerr, Marcus
(author)
-
Duan, Qing
(author)
-
Eaton, Charles B.
(author)
-
Ehret, Georg
(author)
-
Evangelou, Evangelos
(author)
-
Faul, Jessica D.
(author)
-
Forouhi, Nita G.
(author)
-
Franco, Oscar H.
(author)
-
Friedlander, Yechiel
(author)
-
Gao, He
(author)
-
Gigante, BrunaKarolinska Institutet
(author)
-
Gu, C. Charles
(author)
-
Gupta, Preeti
(author)
-
Hagenaars, Saskia P.
(author)
-
Harris, Tamara B.
(author)
-
He, Jiang
(author)
-
Heikkinen, Sami
(author)
-
Heng, Chew-Kiat
(author)
-
Hofman, Albert
(author)
-
Howard, Barbara, V
(author)
-
Hunt, Steven C.
(author)
-
Irvin, Marguerite R.
(author)
-
Jia, Yucheng
(author)
-
Katsuya, Tomohiro
(author)
-
Kaufman, Joel
(author)
-
Kerrison, Nicola D.
(author)
-
Khor, Chiea Chuen
(author)
-
Koh, Woon-Puay
(author)
-
Koistinen, Heikki A.
(author)
-
Kooperberg, Charles B.
(author)
-
Krieger, Jose E.
(author)
-
Kubo, Michiaki
(author)
-
Kutalik, Zoltan
(author)
-
Kuusisto, Johanna
(author)
-
Lakka, Timo A.
(author)
-
Langefeld, Carl D.
(author)
-
Langenberg, Claudia
(author)
-
Launer, Lenore J.
(author)
-
Lee, Joseph H.
(author)
-
Lehne, Benjamin
(author)
-
Levy, Daniel
(author)
-
Lewis, Cora E.
(author)
-
Li, Yize
(author)
-
Lim, Sing Hui
(author)
-
Liu, Ching-Ti
(author)
-
Liu, Jianjun
(author)
-
Liu, Jingmin
(author)
-
Liu, Yeheng
(author)
-
Loh, Marie
(author)
-
Lohman, Kurt K.
(author)
-
Louie, Tin
(author)
-
Magi, Reedik
(author)
-
Matsuda, Koichi
(author)
-
Meitinger, Thomas
(author)
-
Metspalu, Andres
(author)
-
Milani, Lili
(author)
-
Momozawa, Yukihide
(author)
-
Mosley, Thomas H., Jr.
(author)
-
Nalls, Mike A.
(author)
-
Nasri, Ubaydah
(author)
-
O'Connell, Jeff R.
(author)
-
Ogunniyi, Adesola
(author)
-
Palmas, Walter R.
(author)
-
Palmer, Nicholette D.
(author)
-
Pankow, James S.
(author)
-
Pedersen, Nancy L.Karolinska Institutet
(author)
-
Peters, Annette
(author)
-
Peyser, Patricia A.
(author)
-
Polasek, Ozren
(author)
-
Porteous, David
(author)
-
Raitakari, Olli T.
(author)
-
Renström, FridaUmeå universitet,Enheten för biobanksforskning,Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Skåne University Hospital, Malmö, Sweden(Swepub:umu)frre0001
(author)
-
Rice, Treva K.
(author)
-
Ridker, Paul M.
(author)
-
Robino, Antonietta
(author)
-
Robinson, Jennifer G.
(author)
-
Rose, Lynda M.
(author)
-
Rudan, Igor
(author)
-
Sabanayagam, Charumathi
(author)
-
Salako, Babatunde L.
(author)
-
Sandow, Kevin
(author)
-
Schmidt, Carsten O.
(author)
-
Schreiner, Pamela J.
(author)
-
Scott, William R.
(author)
-
Sever, Peter
(author)
-
Sims, Mario
(author)
-
Sitlani, Colleen M.
(author)
-
Smith, Blair H.
(author)
-
Smith, Jennifer A.
(author)
-
Snieder, Harold
(author)
-
Starr, John M.
(author)
-
Strauch, Konstantin
(author)
-
Tang, Hua
(author)
-
Taylor, Kent D.
(author)
-
Teo, Yik Ying
(author)
-
Tham, Yih Chung
(author)
-
Uitterlinden, Andre G.
(author)
-
Waldenberger, Melanie
(author)
-
Wang, Lihua
(author)
-
Wang, Ya Xing
(author)
-
Wei, Wen Bin
(author)
-
Wilson, Gregory
(author)
-
Wojczynski, Mary K.
(author)
-
Xiang, Yong-Bing
(author)
-
Yao, Jie
(author)
-
Yu, Caizheng
(author)
-
Yuan, Jian-Min
(author)
-
Zonderman, Alan B.
(author)
-
Becker, Diane M.
(author)
-
Boehnke, Michael
(author)
-
Bowden, Donald W.
(author)
-
Chambers, John C.
(author)
-
Chen, Yii-Der Ida
(author)
-
Weir, David R.
(author)
-
de Faire, UlfKarolinska Institutet
(author)
-
Deary, Ian J.
(author)
-
Esko, Tonu
(author)
-
Farrall, Martin
(author)
-
Forrester, Terrence
(author)
-
Freedman, Barry, I
(author)
-
Froguel, Philippe
(author)
-
Gasparini, Paolo
(author)
-
Gieger, Christian
(author)
-
Horta, Bernardo Lessa
(author)
-
Hung, Yi-Jen
(author)
-
Jonas, Jost Bruno
(author)
-
Kato, Norihiro
(author)
-
Kooner, Jaspal S.
(author)
-
Laakso, Markku
(author)
-
Lehtimaki, Terho
(author)
-
Liang, Kae-Woei
(author)
-
Magnusson, Patrik K. E.
(author)
-
Oldehinkel, Albertine J.
(author)
-
Pereira, Alexandre C.
(author)
-
Perls, Thomas
(author)
-
Rauramaa, Rainer
(author)
-
Redline, Susan
(author)
-
Rettig, Rainer
(author)
-
Samani, Nilesh J.
(author)
-
Scott, James
(author)
-
Shu, Xiao-Ou
(author)
-
van Der Harst, Pim
(author)
-
Wagenknecht, Lynne E.
(author)
-
Wareham, Nicholas J.
(author)
-
Watkins, Hugh
(author)
-
Wickremasinghe, Ananda R.
(author)
-
Wu, Tangchun
(author)
-
Kamatani, Yoichiro
(author)
-
Laurie, Cathy C.
(author)
-
Bouchard, Claude
(author)
-
Cooper, Richard S.
(author)
-
Evans, Michele K.
(author)
-
Gudnason, Vilmundur
(author)
-
Hixson, James
(author)
-
Kardia, Sharon L. R.
(author)
-
Kritchevsky, Stephen B.
(author)
-
Psaty, Bruce M.
(author)
-
van Dam, Rob M.
(author)
-
Arnett, Donna K.
(author)
-
Mook-Kanamori, Dennis O.
(author)
-
Fornage, Myriam
(author)
-
Fox, Ervin R.
(author)
-
Hayward, Caroline
(author)
-
van Duijn, Cornelia M.
(author)
-
Tai, E. Shyong
(author)
-
Wong, Tien Yin
(author)
-
Loos, Ruth J. F.
(author)
-
Reiner, Alex P.
(author)
-
Rotimi, Charles N.
(author)
-
Bierut, Laura J.
(author)
-
Zhu, Xiaofeng
(author)
-
Cupples, L. Adrienne
(author)
-
Province, Michael A.
(author)
-
Rotter, Jerome, I
(author)
-
Franks, Paul W.Umeå universitet,Avdelningen för medicin,Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Skåne University Hospital, Malmö, Sweden; Harvard T. H. Chan School of Public Health, Department of Nutrition, Harvard University, Boston, MA, USA(Swepub:umu)pafr0003
(author)
-
Rice, Kenneth
(author)
-
Elliott, Paul
(author)
-
Caulfield, Mark J.
(author)
-
Gauderman, W. James
(author)
-
Munroe, Patricia B.
(author)
-
Rao, Dabeeru C.
(author)
-
Morrison, Alanna C.
(author)
-
Karolinska InstitutetEnheten för biobanksforskning
(creator_code:org_t)
Related titles
-
In:Human Molecular Genetics: Oxford University Press28:15, s. 2615-26330964-69061460-2083
Internet link
Find in a library
To the university's database
- By the author/editor
-
Sung, Yun Ju
-
de Las Fuentes, ...
-
Winkler, Thomas ...
-
Chasman, Daniel, ...
-
Bentley, Amy R.
-
Kraja, Aldi T.
-
show more...
-
Ntalla, Ioanna
-
Warren, Helen R.
-
Guo, Xiuqing
-
Schwander, Karen
-
Manning, Alisa K ...
-
Brown, Michael R ...
-
Aschard, Hugues
-
Feitosa, Mary F.
-
Franceschini, No ...
-
Lu, Yingchang
-
Cheng, Ching-Yu
-
Sim, Xueling
-
Vojinovic, Dina
-
Marten, Jonathan
-
Musani, Solomon ...
-
Kilpelainen, Tuo ...
-
Richard, Melissa ...
-
Aslibekyan, Stel ...
-
Bartz, Traci M.
-
Dorajoo, Rajkuma ...
-
Li, Changwei
-
Liu, Yongmei
-
Rankinen, Tuomo
-
Smith, Albert Ve ...
-
Tajuddin, Salman ...
-
Tayo, Bamidele O ...
-
Zhao, Wei
-
Zhou, Yanhua
-
Matoba, Nana
-
Sofer, Tamar
-
Alver, Maris
-
Amini, Marzyeh
-
Boissel, Mathild ...
-
Chai, Jin Fang
-
Chen, Xu
-
Divers, Jasmin
-
Gandin, Ilaria
-
Gao, Chuan
-
Giulianini, Fran ...
-
Goel, Anuj
-
Harris, Sarah E.
-
Hartwig, Fernand ...
-
He, Meian
-
Horimoto, Andrea ...
-
Hsu, Fang-Chi
-
Jackson, Anne U.
-
Kammerer, Candac ...
-
Kasturiratne, An ...
-
Komulainen, Pirj ...
-
Kuehnel, Brigitt ...
-
Leander, Karin
-
Lee, Wen-Jane
-
Lin, Keng-Hung
-
Luan, Jian'an
-
Lyytikainen, Leo ...
-
McKenzie, Colin ...
-
Nelson, Christop ...
-
Noordam, Raymond
-
Scott, Robert A.
-
Sheu, Wayne H. H ...
-
Stancakova, Alen ...
-
Takeuchi, Fumihi ...
-
van Der Most, Pe ...
-
Varga, Tibor V.
-
Waken, Robert J.
-
Wang, Heming
-
Wang, Yajuan
-
Ware, Erin B.
-
Weiss, Stefan
-
Wen, Wanqing
-
Yanek, Lisa R.
-
Zhang, Weihua
-
Zhao, Jing Hua
-
Afaq, Saima
-
Alfred, Tamuno
-
Amin, Najaf
-
Arking, Dan E.
-
Aung, Tin
-
Barr, R. Graham
-
Bielak, Lawrence ...
-
Boerwinkle, Eric
-
Bottinger, Erwin ...
-
Braund, Peter S.
-
Brody, Jennifer ...
-
Broeckel, Ulrich
-
Cade, Brian
-
Campbell, Archie
-
Canouil, Mickael
-
Chakravarti, Ara ...
-
Cocca, Massimili ...
-
Collins, Francis ...
-
Connell, John M.
-
de Mutsert, Rene ...
-
de Silva, H. Jan ...
-
Doerr, Marcus
-
Duan, Qing
-
Eaton, Charles B ...
-
Ehret, Georg
-
Evangelou, Evang ...
-
Faul, Jessica D.
-
Forouhi, Nita G.
-
Franco, Oscar H.
-
Friedlander, Yec ...
-
Gao, He
-
Gigante, Bruna
-
Gu, C. Charles
-
Gupta, Preeti
-
Hagenaars, Saski ...
-
Harris, Tamara B ...
-
He, Jiang
-
Heikkinen, Sami
-
Heng, Chew-Kiat
-
Hofman, Albert
-
Howard, Barbara, ...
-
Hunt, Steven C.
-
Irvin, Marguerit ...
-
Jia, Yucheng
-
Katsuya, Tomohir ...
-
Kaufman, Joel
-
Kerrison, Nicola ...
-
Khor, Chiea Chue ...
-
Koh, Woon-Puay
-
Koistinen, Heikk ...
-
Kooperberg, Char ...
-
Krieger, Jose E.
-
Kubo, Michiaki
-
Kutalik, Zoltan
-
Kuusisto, Johann ...
-
Lakka, Timo A.
-
Langefeld, Carl ...
-
Langenberg, Clau ...
-
Launer, Lenore J ...
-
Lee, Joseph H.
-
Lehne, Benjamin
-
Levy, Daniel
-
Lewis, Cora E.
-
Li, Yize
-
Lim, Sing Hui
-
Liu, Ching-Ti
-
Liu, Jianjun
-
Liu, Jingmin
-
Liu, Yeheng
-
Loh, Marie
-
Lohman, Kurt K.
-
Louie, Tin
-
Magi, Reedik
-
Matsuda, Koichi
-
Meitinger, Thoma ...
-
Metspalu, Andres
-
Milani, Lili
-
Momozawa, Yukihi ...
-
Mosley, Thomas H ...
-
Nalls, Mike A.
-
Nasri, Ubaydah
-
O'Connell, Jeff ...
-
Ogunniyi, Adesol ...
-
Palmas, Walter R ...
-
Palmer, Nicholet ...
-
Pankow, James S.
-
Pedersen, Nancy ...
-
Peters, Annette
-
Peyser, Patricia ...
-
Polasek, Ozren
-
Porteous, David
-
Raitakari, Olli ...
-
Renström, Frida
-
Rice, Treva K.
-
Ridker, Paul M.
-
Robino, Antoniet ...
-
Robinson, Jennif ...
-
Rose, Lynda M.
-
Rudan, Igor
-
Sabanayagam, Cha ...
-
Salako, Babatund ...
-
Sandow, Kevin
-
Schmidt, Carsten ...
-
Schreiner, Pamel ...
-
Scott, William R ...
-
Sever, Peter
-
Sims, Mario
-
Sitlani, Colleen ...
-
Smith, Blair H.
-
Smith, Jennifer ...
-
Snieder, Harold
-
Starr, John M.
-
Strauch, Konstan ...
-
Tang, Hua
-
Taylor, Kent D.
-
Teo, Yik Ying
-
Tham, Yih Chung
-
Uitterlinden, An ...
-
Waldenberger, Me ...
-
Wang, Lihua
-
Wang, Ya Xing
-
Wei, Wen Bin
-
Wilson, Gregory
-
Wojczynski, Mary ...
-
Xiang, Yong-Bing
-
Yao, Jie
-
Yu, Caizheng
-
Yuan, Jian-Min
-
Zonderman, Alan ...
-
Becker, Diane M.
-
Boehnke, Michael
-
Bowden, Donald W ...
-
Chambers, John C ...
-
Chen, Yii-Der Id ...
-
Weir, David R.
-
de Faire, Ulf
-
Deary, Ian J.
-
Esko, Tonu
-
Farrall, Martin
-
Forrester, Terre ...
-
Freedman, Barry, ...
-
Froguel, Philipp ...
-
Gasparini, Paolo
-
Gieger, Christia ...
-
Horta, Bernardo ...
-
Hung, Yi-Jen
-
Jonas, Jost Brun ...
-
Kato, Norihiro
-
Kooner, Jaspal S ...
-
Laakso, Markku
-
Lehtimaki, Terho
-
Liang, Kae-Woei
-
Magnusson, Patri ...
-
Oldehinkel, Albe ...
-
Pereira, Alexand ...
-
Perls, Thomas
-
Rauramaa, Rainer
-
Redline, Susan
-
Rettig, Rainer
-
Samani, Nilesh J ...
-
Scott, James
-
Shu, Xiao-Ou
-
van Der Harst, P ...
-
Wagenknecht, Lyn ...
-
Wareham, Nichola ...
-
Watkins, Hugh
-
Wickremasinghe, ...
-
Wu, Tangchun
-
Kamatani, Yoichi ...
-
Laurie, Cathy C.
-
Bouchard, Claude
-
Cooper, Richard ...
-
Evans, Michele K ...
-
Gudnason, Vilmun ...
-
Hixson, James
-
Kardia, Sharon L ...
-
Kritchevsky, Ste ...
-
Psaty, Bruce M.
-
van Dam, Rob M.
-
Arnett, Donna K.
-
Mook-Kanamori, D ...
-
Fornage, Myriam
-
Fox, Ervin R.
-
Hayward, Carolin ...
-
van Duijn, Corne ...
-
Tai, E. Shyong
-
Wong, Tien Yin
-
Loos, Ruth J. F.
-
Reiner, Alex P.
-
Rotimi, Charles ...
-
Bierut, Laura J.
-
Zhu, Xiaofeng
-
Cupples, L. Adri ...
-
Province, Michae ...
-
Rotter, Jerome, ...
-
Franks, Paul W.
-
Rice, Kenneth
-
Elliott, Paul
-
Caulfield, Mark ...
-
Gauderman, W. Ja ...
-
Munroe, Patricia ...
-
Rao, Dabeeru C.
-
Morrison, Alanna ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Medical Genetics
- Articles in the publication
-
Human Molecular ...
- By the university
-
Umeå University
-
Karolinska Institutet