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Global, regional, a...
Global, regional, and national burden of neurological disorders, 1990–2016 : a systematic analysis for the Global Burden of Disease Study 2016
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Feigin, Valery L. (author)
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Nichols, Emma (author)
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Alam, Tahiya (author)
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Bannick, Marlena S. (author)
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Beghi, Ettore (author)
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Blake, Natacha (author)
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Culpepper, William J. (author)
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Dorsey, E. Ray (author)
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Elbaz, Alexis (author)
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Ellenbogen, Richard G. (author)
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Fisher, James L. (author)
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Fitzmaurice, Christina (author)
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Giussani, Giorgia (author)
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Glennie, Linda (author)
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James, Spencer L. (author)
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Johnson, Catherine Owens (author)
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Kassebaum, Nicholas J. (author)
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Logroscino, Giancarlo (author)
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Marin, Benoit (author)
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Mountjoy-Venning, W. Cliff (author)
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Nguyen, Minh (author)
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Ofori-Asenso, Richard (author)
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Patel, Anoop P. (author)
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Piccininni, Marco (author)
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Roth, Gregory A. (author)
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Steiner, Timothy J. (author)
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Stovner, Lars Jacob (author)
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Szoeke, Cassandra E. I. (author)
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Theadom, Alice (author)
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Vollset, Stein Emil (author)
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Wallin, Mitchell Taylor (author)
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Wright, Claire (author)
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Zunt, Joseph Raymond (author)
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Abbasi, Nooshin (author)
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Abd-Allah, Foad (author)
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- Abdelalim, Ahmed (author)
- Karolinska Institutet
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Abdollahpour, Ibrahim (author)
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Aboyans, Victor (author)
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Abraha, Haftom Niguse (author)
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Acharya, Dilaram (author)
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Adamu, Abdu A. (author)
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Adebayo, Oladimeji M. (author)
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Adeoye, Abiodun Moshood (author)
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Adsuar, Jose C. (author)
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Afarideh, Mohsen (author)
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Agrawal, Sutapa (author)
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Ahmadi, Alireza (author)
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Ahmed, Muktar Beshir (author)
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Aichour, Amani Nidhal (author)
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Aichour, Ibtihel (author)
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Aichour, Miloud Taki Eddine (author)
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Akinyemi, Rufus Olusola (author)
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Akseer, Nadia (author)
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Al-Eyadhy, Ayman (author)
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Salman, Rustam Al-Shahi (author)
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Alahdab, Fares (author)
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Alene, Kefyalew Addis (author)
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Aljunid, Syed Mohamed (author)
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Altirkawi, Khalid (author)
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Alvis-Guzman, Nelson (author)
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Anber, Nahla Hamed (author)
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Antonio, Carl Abelardo T. (author)
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Arabloo, Jalal (author)
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Aremu, Olatunde (author)
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- Ärnlöv, Johan, 1970- (author)
- Karolinska Institutet,Högskolan Dalarna,Medicinsk vetenskap,Karolinska institutet
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Asayesh, Hamid (author)
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Asghar, Rana Jawad (author)
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Atalay, Hagos Tasew (author)
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Awasthi, Ashish (author)
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Ayala Quintanilla, Beatriz Paulina (author)
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Ayuk, Tambe B. (author)
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Badawi, Alaa (author)
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Banach, Maciej (author)
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Banoub, Joseph Adel Mattar (author)
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Barboza, Miguel A. (author)
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Barker-Collo, Suzanne Lyn (author)
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Barnighausen, Till Winfried (author)
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Baune, Bernhard T. (author)
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Bedi, Neeraj (author)
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Behzadifar, Masoud (author)
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Behzadifar, Meysam (author)
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Bejot, Yannick (author)
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Bekele, Bayu Begashaw (author)
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Belachew, Abate Bekele (author)
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Bennett, Derrick A. (author)
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Bensenor, Isabela M. (author)
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Berhane, Adugnaw (author)
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Beuran, Mircea (author)
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Bhattacharyya, Krittika (author)
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Bhutta, Zulfiqar A. (author)
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Biadgo, Belete (author)
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Bijani, Ali (author)
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Bililign, Nigus (author)
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Bin Sayeed, Muhammad Shahdaat (author)
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Blazes, Christopher Kynrint (author)
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Brayne, Carol (author)
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Butt, Zahid A. (author)
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Campos-Nonato, Ismael R. (author)
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Cantu-Brito, Carlos (author)
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Car, Mate (author)
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Cardenas, Rosario (author)
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- Carrero, Juan J. (author)
- Karolinska Institutet
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Carvalho, Felix (author)
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Castaneda-Orjuela, Carlos A. (author)
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Castro, Franz (author)
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Catala-Lopez, Ferran (author)
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Cerin, Ester (author)
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Chaiah, Yazan (author)
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Chang, Jung-Chen (author)
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Chatziralli, Irini (author)
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Chiang, Peggy Pei-Chia (author)
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Christensen, Hanne (author)
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Christopher, Devasahayam J. (author)
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Cooper, Cyrus (author)
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Cortesi, Paolo Angelo (author)
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Costa, Vera M. (author)
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Criqui, Michael H. (author)
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Crowe, Christopher Stephen (author)
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Damasceno, Albertino Antonio Moura (author)
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Daryani, Ahmad (author)
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De la Cruz-Gongora, Vanessa (author)
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Pio De la Hoz, Fernando (author)
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De Leo, Diego (author)
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Degefa, Meaza Girma (author)
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Demoz, Gebre Teklemariam (author)
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Deribe, Kebede (author)
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Dharmaratne, Samath Dhamminda (author)
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Diaz, Daniel (author)
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Dinberu, Mesfin Tadese (author)
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Djalalinia, Shirin (author)
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Doku, David Teye (author)
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Dubey, Manisha (author)
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Dubljanin, Eleonora (author)
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Duken, Eyasu Ejeta (author)
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- Edvardsson, David (author)
- Umeå universitet,Institutionen för omvårdnad
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- El-Khatib, Ziad (author)
- Karolinska Institutet
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Endres, Matthias (author)
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Endries, Aman Yesuf (author)
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Eskandarieh, Sharareh (author)
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Esteghamati, Alireza (author)
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Esteghamati, Sadaf (author)
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Farhadi, Farzaneh (author)
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Faro, Andre (author)
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Farzadfar, Farshad (author)
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Farzaei, Mohammad Hosein (author)
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Fatima, Batool (author)
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- Fereshtehnejad, Seyed-Mohammad (author)
- Karolinska Institutet
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Fernandes, Eduarda (author)
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Feyissa, Garumma Tolu (author)
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Filip, Irina (author)
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Fischer, Florian (author)
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Fukumoto, Takeshi (author)
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Ganji, Morsaleh (author)
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Gankpe, Fortune Gbetoho (author)
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Garcia-Gordillo, Miguel A. (author)
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Gebre, Abadi Kahsu (author)
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Gebremichael, Teklu Gebrehiwo (author)
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Gelaw, Belayneh K. (author)
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Geleijnse, Johanna M. (author)
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Geremew, Demeke (author)
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Gezae, Kebede Embaye (author)
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Ghasemi-Kasman, Maryam (author)
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Gidey, Mahari Y. (author)
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Gill, Paramjit Singh (author)
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Gill, Tiffany K. (author)
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Gnedovskaya, Elena V. (author)
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Goulart, Alessandra C. (author)
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Grada, Ayman (author)
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Grosso, Giuseppe (author)
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Guo, Yuming (author)
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Gupta, Rahul (author)
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Gupta, Rajeev (author)
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Haagsma, Juanita A. (author)
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Hagos, Tekleberhan B. (author)
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Haj-Mirzaian, Arvin (author)
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Haj-Mirzaian, Arya (author)
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Hamadeh, Randah R. (author)
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Hamidi, Samer (author)
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Hankey, Graeme J. (author)
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Hao, Yuantao (author)
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Haro, Josep Maria (author)
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Hassankhani, Hadi (author)
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Hassen, Hamid Yimam (author)
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Havmoeller, Rasmus (author)
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Hay, Simon I. (author)
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Hegazy, Mohamed I. (author)
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Heidari, Behnam (author)
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Henok, Andualem (author)
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Heydarpour, Fatemeh (author)
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Hoang, Chi Linh (author)
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Hole, Michael K. (author)
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Rad, Enayatollah Homaie (author)
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Hosseini, Seyed Mostafa (author)
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Hu, Guoqing (author)
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Igumbor, Ehimario U. (author)
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Ilesanmi, Olayinka Stephen (author)
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Irvani, Seyed Sina Naghibi (author)
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Islam, Sheikh Mohammed Shariful (author)
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Jakovljevic, Mihajlo (author)
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Javanbakht, Mehdi (author)
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Jha, Ravi Prakash (author)
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Jobanputra, Yash B. (author)
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Jonas, Jost B. (author)
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Jozwiak, Jacek Jerzy (author)
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Jurisson, Mikk (author)
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Kahsay, Amaha (author)
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Kalani, Rizwan (author)
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Kalkonde, Yogeshwar (author)
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Kamil, Teshome Abegaz (author)
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Kanchan, Tanuj (author)
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Karami, Manoochehr (author)
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Karch, Andre (author)
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Karimi, Narges (author)
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Kasaeian, Amir (author)
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Kassa, Tesfaye Dessale (author)
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Kassa, Zemenu Yohannes (author)
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Kaul, Anil (author)
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Kefale, Adane Teshome (author)
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Keiyoro, Peter Njenga (author)
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Khader, Yousef Saleh (author)
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Khafaie, Morteza Abdullatif (author)
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Khalil, Ibrahim A. (author)
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Khan, Ejaz Ahmad (author)
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Khang, Young-Ho (author)
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Khazaie, Habibolah (author)
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- Ahmad Kiadaliri, Aliasghar (author)
- Lund University,Lunds universitet,Ortopedi, Lund,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund OsteoArthritis Division - Clinical Epidemiology Unit,Forskargrupper vid Lunds universitet,Orthopaedics (Lund),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups
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Kiirithio, Daniel N. (author)
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Kim, Anthony S. (author)
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Kim, Daniel (author)
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Kim, Young-Eun (author)
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Kim, Yun Jin (author)
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Kisa, Adnan (author)
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Kokubo, Yoshihiro (author)
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Koyanagi, Ai (author)
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Krishnamurthi, Rita V. (author)
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Defo, Barthelemy Kuate (author)
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Bicer, Burcu Kucuk (author)
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Kumar, Manasi (author)
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Lacey, Ben (author)
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Lafranconi, Alessandra (author)
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Lansingh, Van C. (author)
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Latifi, Arman (author)
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Leshargie, Cheru Tesema (author)
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Li, Shanshan (author)
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Liao, Yu (author)
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Linn, Shai (author)
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Lo, Warren David (author)
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Lopez, Jaifred Christian F. (author)
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Lorkowski, Stefan (author)
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Lotufo, Paulo A. (author)
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Lucas, Robyn M. (author)
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Lunevicius, Raimundas (author)
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Mackay, Mark T. (author)
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Mahotra, Narayan Bahadur (author)
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Majdan, Marek (author)
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Majdzadeh, Reza (author)
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Majeed, Azeem (author)
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Malekzadeh, Reza (author)
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Malta, Deborah Carvalho (author)
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Manafi, Navid (author)
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Mansournia, Mohammad Ali (author)
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Mantovani, Lorenzo Giovanni (author)
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Marz, Winfried (author)
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Mashamba-Thompson, Tivani Phosa (author)
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Massenburg, Benjamin Ballard (author)
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Mate, Kedar K. V. (author)
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McAlinden, Colm (author)
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McGrath, John J. (author)
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Mehta, Varshil (author)
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Meier, Toni (author)
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Meles, Hagazi Gebre (author)
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Melese, Addisu (author)
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Memiah, Peter T. N. (author)
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Memish, Ziad A. (author)
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Mendoza, Walter (author)
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Mengistu, Desalegn Tadese (author)
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Mengistu, Getnet (author)
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Meretoja, Atte (author)
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Meretoja, Tuomo J. (author)
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Mestrovic, Tomislav (author)
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Miazgowski, Bartosz (author)
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Miazgowski, Tomasz (author)
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Miller, Ted R. (author)
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Mini, G. K. (author)
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Mirrakhimov, Erkin M. (author)
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Moazen, Babak (author)
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Mohajer, Bahram (author)
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Mezerji, Naser Mohammad Gholi (author)
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Mohammadi, Moslem (author)
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Mohammadi-Khanaposhtani, Maryam (author)
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Mohammadibakhsh, Roghayeh (author)
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Mohammadnia-Afrouzi, Mousa (author)
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Mohammed, Shafiu (author)
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Mohebi, Farnam (author)
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Mokdad, Ali H. (author)
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Monasta, Lorenzo (author)
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Mondello, Stefania (author)
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Moodley, Yoshan (author)
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Moosazadeh, Mahmood (author)
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Moradi, Ghobad (author)
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Moradi-Lakeh, Maziar (author)
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Moradinazar, Mehdi (author)
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Moraga, Paula (author)
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Velasquez, Ilais Moreno (author)
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Morrison, Shane Douglas (author)
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Mousavi, Seyyed Meysam (author)
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Muhammed, Oumer Sada (author)
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Muruet, Walter (author)
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Musa, Kamarul Imran (author)
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Mustafa, Ghulam (author)
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Naderi, Mehdi (author)
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Nagel, Gabriele (author)
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Naheed, Aliya (author)
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Naik, Gurudatta (author)
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Najafi, Farid (author)
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Nangia, Vinay (author)
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Negoi, Ionut (author)
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Negoi, Ruxandra Irina (author)
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Newton, Charles Richard James (author)
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Ngunjiri, Josephine W. (author)
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Nguyen, Cuong Tat (author)
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Nguyen, Long Hoang (author)
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Ningrum, Dina Nur Anggraini (author)
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Nirayo, Yirga Legesse (author)
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Nixon, Molly R. (author)
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Norrving, Bo (author)
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Noubiap, Jean Jacques (author)
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Shiadeh, Malihe Nourollahpour (author)
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Nyasulu, Peter S. (author)
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Ogbo, Felix Akpojene (author)
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Oh, In-Hwan (author)
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Olagunju, Andrew T. (author)
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Olagunju, Tinuke O. (author)
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Olivares, Pedro R. (author)
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Onwujekwe, Obinna E. (author)
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Oren, Eyal (author)
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Owolabi, Mayowa Ojo (author)
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Mahesh, P. A. (author)
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Pakpour, Amir H. (author)
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Pan, Wen-Harn (author)
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Panda-Jonas, Songhomitra (author)
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Pandian, Jeyaraj Durai (author)
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Patel, Sangram Kishor (author)
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Pereira, David M. (author)
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- Petzold, Max, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa, enheten för hälsometri,Institute of Medicine, Department of Public Health and Community Medicine, Health Metrics
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Pillay, Julian David (author)
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Piradov, Michael A. (author)
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Polanczyk, Guilherme V. (author)
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Polinder, Suzanne (author)
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Postma, Maarten J. (author)
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Poulton, Richie (author)
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Poustchi, Hossein (author)
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Prakash, Swayam (author)
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Prakash, V. (author)
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Qorbani, Mostafa (author)
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Radfar, Amir (author)
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Rafay, Anwar (author)
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Rafiei, Alireza (author)
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Rahim, Fakher (author)
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Rahimi-Movaghar, Vafa (author)
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Rahman, Mahfuzar (author)
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Rahman, Mohammad Hifz Ur (author)
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Rahman, Muhammad Aziz (author)
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Rajati, Fatemeh (author)
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Ram, Usha (author)
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Ranta, Anna (author)
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Rawaf, David Laith (author)
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Rawaf, Salman (author)
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Reinig, Nickolas (author)
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Reis, Cesar (author)
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Renzaho, Andre M. N. (author)
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Resnikoff, Serge (author)
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Rezaeian, Shahab (author)
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Rezai, Mohammad Sadegh (author)
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Gonzalez, Carlos Miguel Rios (author)
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Roberts, Nicholas L. S. (author)
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Roever, Leonardo (author)
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Ronfani, Luca (author)
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Roro, Elias Merdassa (author)
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Roshandel, Gholamreza (author)
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Rostami, Ali (author)
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Sabbagh, Parisa (author)
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Sacco, Ralph L. (author)
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Sachdev, Perminder S. (author)
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Saddik, Basema (author)
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Safari, Hosein (author)
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Safari-Faramani, Roya (author)
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Safi, Sare (author)
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Safiri, Saeid (author)
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Sagar, Rajesh (author)
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Sahathevan, Ramesh (author)
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Sahebkar, Amirhossein (author)
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Sahraian, Mohammad Ali (author)
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Salamati, Payman (author)
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Zahabi, Saleh Salehi (author)
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Salimi, Yahya (author)
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Samy, Abdallah M. (author)
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Sanabria, Juan (author)
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Santos, Itamar S. (author)
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Milicevic, Milena M. Santric (author)
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Sarrafzadegan, Nizal (author)
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Sartorius, Benn (author)
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Sarvi, Shahabeddin (author)
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Sathian, Brijesh (author)
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Satpathy, Maheswar (author)
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Sawant, Arundhati R. (author)
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Sawhney, Monika (author)
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Schneider, Ione J. C. (author)
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Schottker, Ben (author)
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Schwebel, David C. (author)
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Seedat, Soraya (author)
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Sepanlou, Sadaf G. (author)
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Shabaninejad, Hosein (author)
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Shafieesabet, Azadeh (author)
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Shaikh, Masood Ali (author)
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Shakir, Raad A. (author)
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Shams-Beyranvand, Mehran (author)
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Shamsizadeh, Morteza (author)
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Sharif, Mehdi (author)
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Sharif-Alhoseini, Mahdi (author)
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She, Jun (author)
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Sheikh, Aziz (author)
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Sheth, Kevin N. (author)
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Shigematsu, Mika (author)
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Shiri, Rahman (author)
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Shirkoohi, Reza (author)
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Shiue, Ivy (author)
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Siabani, Soraya (author)
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Siddiqi, Tariq J. (author)
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Sigfusdottir, Inga Dora (author)
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Sigurvinsdottir, Rannveig (author)
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Silberberg, Donald H. (author)
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Silva, Joao Pedro (author)
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Silveira, Dayane Gabriele Alves (author)
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Singh, Jasvinder A. (author)
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Sinha, Dhirendra Narain (author)
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Skiadaresi, Eirini (author)
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Smith, Mari (author)
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Sobaih, Badr Hasan (author)
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Sobhani, Soheila (author)
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Soofi, Moslem (author)
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Soyiri, Ireneous N. (author)
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Sposato, Luciano A. (author)
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Stein, Dan J. (author)
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Stein, Murray B. (author)
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Stokes, Mark A. (author)
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Sufiyan, Mu'awiyyah Babale (author)
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Sykes, Bryan L. (author)
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Sylaja, Pn (author)
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Tabares-Seisdedos, Rafael (author)
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Ao, Braden James Te (author)
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Tehrani-Banihashemi, Arash (author)
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Temsah, Mohamad-Hani (author)
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Temsah, Omar (author)
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Thakur, Jarnail Singh (author)
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Thrift, Amanda G. (author)
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Topor-Madry, Roman (author)
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Tortajada-Girbes, Miguel (author)
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Tovani-Palone, Marcos Roberto (author)
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Tran, Bach Xuan (author)
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Tran, Khanh Bao (author)
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Truelsen, Thomas Clement (author)
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Tsadik, Afewerki Gebremeskel (author)
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Car, Lorainne Tudor (author)
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Ukwaja, Kingsley Nnanna (author)
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Ullah, Irfan (author)
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Usman, Muhammad Shariq (author)
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Uthman, Olalekan A. (author)
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Valdez, Pascual R. (author)
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Vasankari, Tommi Juhani (author)
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Vasanthan, Rajagopalan (author)
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Veisani, Yousef (author)
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Venketasubramanian, Narayanaswamy (author)
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Violante, Francesco S. (author)
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Vlassov, Vasily (author)
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Vosoughi, Kia (author)
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Vu, Giang Thu (author)
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Vujcic, Isidora S. (author)
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Wagnew, Fasil Shiferaw (author)
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Waheed, Yasir (author)
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Wang, Yuan-Pang (author)
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- Weiderpass, Elisabete (author)
- Karolinska Institutet
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Weiss, Jordan (author)
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Whiteford, Harvey A. (author)
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Wijeratne, Tissa (author)
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Winkler, Andrea Sylvia (author)
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Wiysonge, Charles Shey (author)
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Wolfe, Charles D. A. (author)
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Xu, Gelin (author)
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Yadollahpour, Ali (author)
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Yamada, Tomohide (author)
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Yano, Yuichiro (author)
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Yaseri, Mehdi (author)
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Yatsuya, Hiroshi (author)
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Yimer, Ebrahim M. (author)
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Yip, Paul (author)
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Yisma, Engida (author)
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Yonemoto, Naohiro (author)
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Yousefifard, Mahmoud (author)
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Yu, Chuanhua (author)
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Zaidi, Zoubida (author)
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Bin Zaman, Sojib (author)
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Zamani, Mohammad (author)
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Zandian, Hamed (author)
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Zare, Zohreh (author)
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Zhang, Yunquan (author)
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Zodpey, Sanjay (author)
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Naghavi, Mohsen (author)
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Murray, Christopher J. L. (author)
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Vos, Theo (author)
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Culpepper, Will (author)
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- Elsevier, 2019
- 2019
- English.
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In: Lancet Neurology. - : Elsevier. - 1474-4422 .- 1474-4465. ; 18:5, s. 459-480
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Abstract
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- Background: Neurological disorders are increasingly recognised as major causes of death and disability worldwide. The aim of this analysis from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2016 is to provide the most comprehensive and up-to-date estimates of the global, regional, and national burden from neurological disorders.Methods: We estimated prevalence, incidence, deaths, and disability-adjusted life-years (DALYs; the sum of years of life lost [YLLs] and years lived with disability [YLDs]) by age and sex for 15 neurological disorder categories (tetanus, meningitis, encephalitis, stroke, brain and other CNS cancers, traumatic brain injury, spinal cord injury, Alzheimer's disease and other dementias, Parkinson's disease, multiple sclerosis, motor neuron diseases, idiopathic epilepsy, migraine, tension-type headache, and a residual category for other less common neurological disorders) in 195 countries from 1990 to 2016. DisMod-MR 2.1, a Bayesian meta-regression tool, was the main method of estimation of prevalence and incidence, and the Cause of Death Ensemble model (CODEm) was used for mortality estimation. We quantified the contribution of 84 risks and combinations of risk to the disease estimates for the 15 neurological disorder categories using the GBD comparative risk assessment approach.Findings: Globally, in 2016, neurological disorders were the leading cause of DALYs (276 million [95% UI 247–308]) and second leading cause of deaths (9·0 million [8·8–9·4]). The absolute number of deaths and DALYs from all neurological disorders combined increased (deaths by 39% [34–44] and DALYs by 15% [9–21]) whereas their age-standardised rates decreased (deaths by 28% [26–30] and DALYs by 27% [24–31]) between 1990 and 2016. The only neurological disorders that had a decrease in rates and absolute numbers of deaths and DALYs were tetanus, meningitis, and encephalitis. The four largest contributors of neurological DALYs were stroke (42·2% [38·6–46·1]), migraine (16·3% [11·7–20·8]), Alzheimer's and other dementias (10·4% [9·0–12·1]), and meningitis (7·9% [6·6–10·4]). For the combined neurological disorders, age-standardised DALY rates were significantly higher in males than in females (male-to-female ratio 1·12 [1·05–1·20]), but migraine, multiple sclerosis, and tension-type headache were more common and caused more burden in females, with male-to-female ratios of less than 0·7. The 84 risks quantified in GBD explain less than 10% of neurological disorder DALY burdens, except stroke, for which 88·8% (86·5–90·9) of DALYs are attributable to risk factors, and to a lesser extent Alzheimer's disease and other dementias (22·3% [11·8–35·1] of DALYs are risk attributable) and idiopathic epilepsy (14·1% [10·8–17·5] of DALYs are risk attributable).Interpretation: Globally, the burden of neurological disorders, as measured by the absolute number of DALYs, continues to increase. As populations are growing and ageing, and the prevalence of major disabling neurological disorders steeply increases with age, governments will face increasing demand for treatment, rehabilitation, and support services for neurological disorders. The scarcity of established modifiable risks for most of the neurological burden demonstrates that new knowledge is required to develop effective prevention and treatment strategies.Funding: Bill & Melinda Gates Foundation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences (hsv//eng)
Keyword
- Hälsa och välfärd
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