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Sökning: WFRF:(Yuan Jinghua) > (2020) > Abnormal expression...

  • Lei, JianSchool of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, China (författare)

Abnormal expression of chondroitin sulfate sulfotransferases in the articular cartilage of pediatric patients with Kashin-Beck disease

  • Artikel/kapitelEngelska2020

Förlag, utgivningsår, omfång ...

  • 2019-12-16
  • Springer Science and Business Media LLC,2020
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-166647
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-166647URI
  • https://doi.org/10.1007/s00418-019-01833-0DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • The objective of this study is to investigate the expression of enzymes involved in the sulfation of articular cartilage from proximal metacarpophalangeal (PMC) joint cartilage and distal metacarpophalangeal (DMC) joint cartilage in children with Kashin-Beck disease (KBD). The finger cartilage samples of PMC and DMC were collected from KBD and normal children aged 5-14 years old. Hematoxylin and eosin staining as well as immunohistochemical staining were used to observe the morphology and quantitate the expression of carbohydrate sulfotransferase 3 (CHST-3), carbohydrate sulfotransferase 12 (CHST-12), carbohydrate sulfotransferase 13 (CHST-13), uronyl 2-O-sulfotransferase (UST), and aggrecan. In the results, the numbers of chondrocyte decreased in all three zones of PMC and DMC in the KBD group. Less positive staining cells for CHST-3, CHST-12, CHST-13, UST, and aggrecan were observed in almost all three zones of PMC and DMC in KBD. The positive staining cell rates of CHST-12 were higher in superficial and middle zones of PMC and DMC in KBD, and a significantly higher rate of CHST-13 was observed only in superficial zone of PMC in KBD. In conclusion, the abnormal expression of chondroitin sulfate sulfotransferases in chondrocytes of KBD children may provide an explanation for the cartilage damage, and provide therapeutic targets for the treatment.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Yan, SiqiShenzhen Institute, Xi'an Jiaotong University, China; Department of Ophthalmology, The First Affiliated Hospital, Health Science Center of Xi'an Jiaotong University, Xi'an, China (författare)
  • Zhou, YuanSchool of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, China (författare)
  • Wang, LiyunSchool of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, China; Shenzhen Institute, Xi'an Jiaotong University, Shenzhen, China (författare)
  • Zhang, JinghuaSchool of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, China (författare)
  • Guo, XiongSchool of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, China (författare)
  • Lammi, Mikko,1961-Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB),School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, P. R. China,Chondrogenic and Osteogenic Differentiation(Swepub:umu)mila0077 (författare)
  • Han, JingShenzhen Institute, Xi'an Jiaotong University, Shenzhen, China (författare)
  • Qu, Chengjuan,1967-Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB),Chondrogenic and Osteogenic Differentiation(Swepub:umu)chqu0007 (författare)
  • School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, ChinaShenzhen Institute, Xi'an Jiaotong University, China; Department of Ophthalmology, The First Affiliated Hospital, Health Science Center of Xi'an Jiaotong University, Xi'an, China (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Histochemistry and Cell Biology: Springer Science and Business Media LLC153:3, s. 153-1640948-61431432-119X

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