SwePub
Sök i LIBRIS databas

  Extended search

WFRF:(Cleveland John L)
 

Search: WFRF:(Cleveland John L) > (2005-2009) > Targeting ornithine...

  • Nilsson, Jonas AUmeå universitet,Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet),Nilsson (author)

Targeting ornithine decarboxylase in Myc-induced lymphomagenesis prevents tumor formation.

  • Article/chapterEnglish2005

Publisher, publication year, extent ...

  • 2005
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-16704
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-16704URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Checkpoints that control Myc-mediated proliferation and apoptosis are bypassed during tumorigenesis. Genes encoding polyamine biosynthetic enzymes are overexpressed in B cells from E mu-Myc transgenic mice. Here, we report that disabling one of these Myc targets, Ornithine decarboxylase (Odc), abolishes Myc-induced suppression of the Cdk inhibitors p21(Cip1) and p27(Kip1), thereby impairing Myc's proliferative, but not apoptotic, response. Moreover, lymphoma development was markedly delayed in E mu-Myc;Odc(+/-) transgenic mice and in E mu-Myc mice treated with the Odc inhibitor difluoromethylornithine (DFMO). Strikingly, tumors ultimately arising in E mu-Myc;Odc(+/-) transgenics lacked deletions of Arf, suggesting that targeting Odc forces other routes of transformation. Therefore, Odc is a critical Myc transcription target that regulates checkpoints that guard against tumorigenesis and is an effective target for cancer chemoprevention.

Subject headings and genre

  • Animals
  • Apoptosis/drug effects
  • B-Lymphocytes/chemistry/drug effects/metabolism
  • Cell Cycle Proteins/genetics/metabolism
  • Cell Proliferation/drug effects
  • Cyclin-Dependent Kinase Inhibitor p16
  • Cyclin-Dependent Kinase Inhibitor p21
  • Cyclin-Dependent Kinase Inhibitor p27
  • Eflornithine/pharmacology
  • Gene Expression/drug effects
  • Gene Expression Regulation; Neoplastic/drug effects
  • Heterozygote
  • Lymphoma/drug therapy/genetics/*metabolism
  • Mice
  • Mice; Inbred C57BL
  • Mice; Knockout
  • Mice; Mutant Strains
  • Mice; Transgenic
  • Organ Size/drug effects
  • Ornithine Decarboxylase/antagonists & inhibitors/genetics/*metabolism
  • Polyamines/metabolism
  • Proto-Oncogene Proteins c-myc/genetics/*metabolism
  • Spleen/pathology
  • Survival Rate
  • Tumor Suppressor Protein p14ARF/genetics/metabolism
  • Tumor Suppressor Proteins/genetics/metabolism

Added entries (persons, corporate bodies, meetings, titles ...)

  • Keller, Ulrich B (author)
  • Baudino, Troy A (author)
  • Yang, Chunying (author)
  • Norton, Sara (author)
  • Old, Jennifer A (author)
  • Nilsson, Lisa MUmeå universitet,Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet),Heby (author)
  • Neale, Geoffrey (author)
  • Kramer, Debora L (author)
  • Porter, Carl W (author)
  • Cleveland, John L (author)
  • Umeå universitetInstitutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet) (creator_code:org_t)

Related titles

  • In:Cancer Cell7:5, s. 433-441535-6108

Internet link

Find in a library

To the university's database

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view