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The novel ETS facto...
The novel ETS factor TEL2 cooperates with Myc in B lymphomagenesis.
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Cardone, Monica (author)
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Kandilci, Ayten (author)
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Carella, Cintia (author)
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- Nilsson, Jonas A (author)
- Umeå universitet,Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet)
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Brennan, Jennifer A (author)
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Sirma, Sema (author)
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Ozbek, Ugur (author)
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Boyd, Kelli (author)
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Cleveland, John L (author)
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Grosveld, Gerard C (author)
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(creator_code:org_t)
- 2005
- 2005
- English.
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In: Mol Cell Biol. - 0270-7306. ; 25:6, s. 2395-405
- Related links:
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http://www.ncbi.nlm....
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https://urn.kb.se/re...
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Abstract
Subject headings
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- The human ETS family gene TEL2/ETV7 is highly homologous to TEL1/ETV6, a frequent target of chromosome translocations in human leukemia and specific solid tumors. Here we report that TEL2 augments the proliferation and survival of normal mouse B cells and dramatically accelerates lymphoma development in Emu-Myc transgenic mice. Nonetheless, inactivation of the p53 pathway was a hallmark of all TEL2/Emu-Myc lymphomas, indicating that TEL2 expression alone is insufficient to bypass this apoptotic checkpoint. Although TEL2 is infrequently up-regulated in human sporadic Burkitt's lymphoma, analysis of pediatric B-cell acute lymphocytic leukemia (B-ALL) samples showed increased coexpression of TEL2 and MYC and/or MYCN in over one-third of B-ALL patients. Therefore, TEL2 and MYC also appear to cooperate in provoking a cadre of human B-cell malignancies.
Keyword
- Animals
- Apoptosis
- B-Lymphocytes/metabolism
- Burkitt Lymphoma/genetics/*metabolism
- Cell Proliferation
- Child
- DNA-Binding Proteins/genetics/*metabolism
- Female
- Humans
- Leukemia; B-Cell; Acute/genetics/*metabolism
- Male
- Mice
- Mice; Transgenic
- Mutation/genetics
- Proto-Oncogene Proteins c-ets
- Proto-Oncogene Proteins c-myc/*metabolism
- Suppression; Genetic
- Transcription Factors/genetics/*metabolism
- Tumor Suppressor Protein p53/genetics
- Up-Regulation/genetics
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Cardone, Monica
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Kandilci, Ayten
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Carella, Cintia
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Nilsson, Jonas A
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Brennan, Jennife ...
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Sirma, Sema
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show more...
-
Ozbek, Ugur
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Boyd, Kelli
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Cleveland, John ...
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Grosveld, Gerard ...
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show less...
- Articles in the publication
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Mol Cell Biol
- By the university
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Umeå University