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  • Cappon, Davide (author)

Globus pallidal deep brain stimulation for Tourette syndrome : Effects on cognitive function

  • Article/chapterEnglish2019

Publisher, publication year, extent ...

  • Elsevier,2019
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-167062
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-167062URI
  • https://doi.org/10.1016/j.parkreldis.2019.10.013DOI

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  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Introduction: In a double-blind randomized crossover trial, we previously established that bilateral deep brain stimulation of the anteromedial globus pallidus internus (GPiam-DBS) is effective in significantly reducing tic severity in patients with refractory Tourette syndrome (TS). Here, we report the effects of bilateral GPiam-DBS on cognitive function in 11 of the 13 patients who had participated in our double-blind cross-over trial of GPi-DBS.Methods: Patients were assessed at baseline (4 weeks prior to surgery) and at the end of each of the three-month blinded periods, with stimulation either ON or OFF. The patients were evaluated on tests of memory (California Verbal Learning Test-II (CVLT-II); Corsi blocks; Short Recognition Memory for Faces), executive function (D-KEFS Stroop color-word interference, verbal fluency, Trail-making test, Hayling Sentence Completion test), and attention (Paced Auditory Serial Addition Test, Numbers and Letters Test).Results: GPiam-DBS did not produce any significant change in global cognition. Relative to pre-operative baseline assessment verbal episodic memory on the CVLT-II and set-shifting on the Trail-making Test were improved with DBS OFF. Performance on the cognitive tests were not different with DBS ON versus DBS OFF. GPiam-DBS did not alter aspects of cognition that are impaired in TS such as inhibition on the Stroop interference task or the Hayling Sentence Completion test.Conclusions: This study extends previous findings providing data showing that GPiam-DBS does not adversely affect cognitive domains such as memory, executive function, verbal fluency, attention, psychomotor speed, and information processing. These results indicate that GPiam-DBS does not produce any cognitive deficits in TS.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Beigi, Mazda (author)
  • Kefalopoulou, Zinovia (author)
  • Zrinzo, Ludvic (author)
  • Candelario, Joseph (author)
  • Milabo, Catherine (author)
  • Akram, Harith (author)
  • Dayal, Viswas (author)
  • Hyam, Jonathan (author)
  • Kass-Iliyya, Lewis (author)
  • Silverdale, Monty (author)
  • Evans, Julian (author)
  • Limousin, Patricia (author)
  • Hariz, MarwanUmeå universitet,Klinisk neurovetenskap,Unit of Functional Neurosurgery, Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, National Hospital for Neurology and Neurosurgery, London, UK(Swepub:umu)hama0032 (author)
  • Joyce, Eileen (author)
  • Foltynie, Thomas (author)
  • Jahanshahi, Marjan (author)
  • Umeå universitetKlinisk neurovetenskap (creator_code:org_t)

Related titles

  • In:Parkinsonism & Related Disorders: Elsevier69, s. 14-181353-80201873-5126

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