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Cerebrospinal Fluid...
Cerebrospinal Fluid Shunting Improves Long-Term Quality of Life in Idiopathic Normal Pressure Hydrocephalus
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- Israelsson, Hanna, 1983- (författare)
- Umeå universitet,Neurovetenskaper,Department of Pharmacology and Clinical Neuroscience, Umeå University, Umeå, Sweden
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- Eklund, Anders, 1965- (författare)
- Umeå universitet,Radiofysik,Centrum för medicinsk teknik och fysik (CMTF),Department of Radiation Sciences, Umeå University, Umeå, Sweden;Center for Biomedical Engineering and Physics, Umeå University, Umeå, Sweden
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- Malm, Jan, Professor, 1957- (författare)
- Umeå universitet,Neurovetenskaper,Department of Pharmacology and Clinical Neuroscience, Umeå University, Umeå, Sweden
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(creator_code:org_t)
- 2020-04
- 2020
- Engelska.
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Ingår i: Neurosurgery. - : Oxford University Press. - 0148-396X .- 1524-4040. ; 86:4, s. 574-582
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- BACKGROUND: The short- and long-term impact of cerebrospinal fluid shunting on quality of life (QoL) in idiopathic normal pressure hydrocephalus (INPH) is poorly understood.OBJECTIVE: To investigate QoL in shunted INPH patients compared to the population and to investigate which factors influence QoL in INPH.METHODS: INPH patients consecutively shunted in Sweden during 2008-2010 were scrutinized. Population-based controls were age- and sex-matched to the patients. Included participants were the following: 176 INPH patients and 368 controls. QoL was assessed using the EuroQol 5-dimension 5-level (EQ5D5L) instrument, which measures overall QoL and health status in 5 dimensions. Independency (accommodation and/or need for in-home care) and comorbidities were assessed. Patients were followed up 6-45 mo after surgery (mean follow-up time: 21 mo).RESULTS: Shunting improved QoL (P < .001) and health status in all dimensions (P < .005). Shunted INPH patients had lower QoL than controls (P < .001). The patients' health status in mobility, self-care, daily activities, and anxiety/depression was worse than the controls both before and after surgery (P < .001). The main predictors of low QoL in INPH were symptoms of depression (P < .001) and severity of gait disturbance (P = .001). Fewer INPH patients than controls lived independently (45% vs 85%, P < .001). Time after shunting had no influence on QoL.CONCLUSION: QoL remains improved in shunted INPH patients at a mean follow-up time of 21 mo, but the patients do not reach the same QoL as the population. Symptoms of depression and severity of gait disturbance are the strongest predictors of low QoL in INPH.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- Case-control studies
- Dementia
- Depression
- Follow-up studies
- Hydrocephalus
- INPH CRASH
- Normal pressure
- Quality of life
- Neurology
- neurologi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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