Sökning: L773:1873 5169 OR L773:0196 9781 >
Effects of TRH and ...
Effects of TRH and atropine on induction and duration of anesthesia with propofol in rats.
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- Larsson, Jan (författare)
- Umeå universitet,Department of Pharmacology, Umeå University, S-901 87 Umeå, Sweden
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- Koskinen, Lars-Owe D., Professor, 1955- (författare)
- Department of Neurosurgery, University Hospital, S-901 85 Umeå, Sweden; Division of Biomedicine, Department of NBC Defence, National Defence Research Establishment, S-901 82 Umeå, Sweden
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- Wahlström, Göran (författare)
- Umeå universitet
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(creator_code:org_t)
- Elsevier BV, 1996
- 1996
- Engelska.
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Ingår i: Peptides. - : Elsevier BV. - 0196-9781 .- 1873-5169. ; 17:2, s. 293-297
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The effects of IV TRH pretreatment on induction of anesthesia with propofol or pentobarbital were investigated in rats. The effects of IV TRH, administered after induction, on duration of propofol anesthesia and the interaction with atropine were also studied. The doses of propofol or pentobarbital were not influenced by TRH. TRH reduced duration of anesthesia after propofol, with higher brain concentrations of propofol at recovery. Atropine did not block this effect, but given alone prolonged duration of anesthesia. It is concluded that TRH shortens the duration of propofol anesthesia, probably due to a pharmacodynamic effect and not to a pharmacokinetic interaction.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Publikations- och innehållstyp
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- art (ämneskategori)
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